GW
Gary R. Whittaker
  • Department of Microbiology and Immunology, Cornell University, Ithaca NY
个人信息

Education

Ph.D in Microbiology, Department of Microbiology, University of Leeds, U.K, 1992

Current Position

Professor, Department of Microbiology & Immunology, Cornell University – College of Veterinary Medicine , Ithaca, NY

Publications (since 2012)

  1. Roldan, J. S., Martinez, M. G., Forlenza, M. B., Whittaker, G. R. and Candurra, N. A. (2016). Human transferrin receptor triggers an alternative Tacaribe virus internalization pathway. Arch Virol 161(2): 353-363.
  2. Rappazzo, C. G., Watkins, H. C., Guarino, C. M., Chau, A., Lopez, J. L., DeLisa, M. P., Leifer, C. A., Whittaker, G. R. and Putnam, D. (2016). Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice. Vaccine 34(10): 1252-1258.
  3. Zhang, Y. and Whittaker, G. R. (2016). Productive infection of avian coronavirus infectious bronchitis virus in chicken peripheral blood-derived monocytes. bioRXiv.
  4. Millet, J. K., Seron, K., Labitt, R. N., Danneels, A., Palmer, K. E., Whittaker, G. R., Dubuisson, J. and Belouzard, S. (2016). Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin. Antiviral Res 133: 1-8.
  5. Hsu, H. L., Millet, J. K., Costello, D. A., Whittaker, G. R. and Daniel, S. (2016). Viral fusion efficacy of specific H3N2 influenza virus reassortant combinations at single-particle level. Sci Rep 6: 35537.
  6. White, J. M. and Whittaker, G. R. (2016). Fusion of Enveloped Viruses in Endosomes. Traffic 17(6): 593-614.
  7. Costello, D. A., Whittaker, G. R. and Daniel, S. (2015). Variations in pH sensitivity, acid stability, and fusogenicity of three influenza virus H3 subtypes. J Virol 89(1): 350-360.
  8. Tse, L. V. and Whittaker, G. R. (2015). Modification of the hemagglutinin cleavage site allows indirect activation of avian influenza virus H9N2 by bacterial staphylokinase. Virology 482: 1-8.
  9. Millet, J. K. and Whittaker, G. R. (2015). Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis. Virus Res 202: 120-134.
  10. Licitra, B. N., Duhamel, G. E. and Whittaker, G. R. (2014). Canine enteric coronaviruses: emerging viral pathogens with distinct recombinant spike proteins. Viruses 6(8): 3363-3376.
  11. Tse, L. V., Hamilton, A. M., Friling, T. and Whittaker, G. R. (2014). A novel activation mechanism of avian influenza virus H9N2 by furin. J Virol 88(3): 1673-1683.
  12. Zhang, Y. and Whittaker, G. R. (2014). Influenza entry pathways in polarized MDCK cells. Biochem Biophys Res Commun 450(1): 234-239.
  13. Hamilton, B. S., Chung, C., Cyphers, S. Y., Rinaldi, V. D., Marcano, V. C. and Whittaker, G. R. (2014). Inhibition of influenza virus infection and hemagglutinin cleavage by the protease inhibitor HAI-2. Biochem Biophys Res Commun 450(2): 1070-1075.
  14. Licitra, B. N., Whittaker, G. R., Dubovi, E. J. and Duhamel, G. E. (2014). Genotypic characterization of canine coronaviruses associated with fatal canine neonatal enteritis in the United States. J Clin Microbiol 52(12): 4230-4238.
  15. Millet, J. K. and Whittaker, G. R. (2014). Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein. Proc Natl Acad Sci U S A 111(42): 15214-15219.
  16. Licitra, B. N., Sams, K. L., Lee, D. W. and Whittaker, G. R. (2014). Feline coronaviruses associated with feline infectious peritonitis have modifications to spike protein activation sites at two discrete positions. arXiv.
  17. Tse, L. V., Marcano, V. C., Huang, W., Pocwierz, M. S. and Whittaker, G. R. (2013). Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin is independent of the viral neuraminidase. J Virol 87(9): 5161-5169.
  18. Hamilton, B. S. and Whittaker, G. R. (2013). Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12. J Biol Chem 288(24): 17399-17407.
  19. Licitra, B. N., Millet, J. K., Regan, A. D., Hamilton, B. S., Rinaldi, V. D., Duhamel, G. E. and Whittaker, G. R. (2013). Mutation in spike protein cleavage site and pathogenesis of feline coronavirus. Emerg Infect Dis 19(7): 1066-1073.
  20. Costello, D. A., Millet, J. K., Hsia, C. Y., Whittaker, G. R. and Daniel, S. (2013). Single particle assay of coronavirus membrane fusion with proteinaceous receptor-embedded supported bilayers. Biomaterials 34(32): 7895-7904.
  21. Martinez, M. G., Bialecki, M. A., Belouzard, S., Cordo, S. M., Candurra, N. A. and Whittaker, G. R. (2013). Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junin virus. Biochem Biophys Res Commun 441(3): 612-617.
  22. Sun, X. and Whittaker, G. R.  (2013). Entry of Influenza Virus. In: Pohlmann, S. and Simmons, G. (eds). Viral Entry into Host Cells.
  23. Regan, A. D. and Whittaker, G. R. (2013). Entry of Rhabdoviruses into Animal Cells. In: Pohlmann, S. and Simmons, G. (eds). Viral Entry into Host Cells.
  24. Zhang, Y., Buckles, E. and Whittaker, G. R. (2012). Expression of the C-type lectins DC-SIGN or L-SIGN alters host cell susceptibility for the avian coronavirus, infectious bronchitis virus. Vet Microbiol 157(3-4): 285-293.
  25. Regan, A. D., Millet, J. K., Tse, L. P., Chillag, Z., Rinaldi, V. D., Licitra, B. N., Dubovi, E. J., Town, C. D. and Whittaker, G. R. (2012). Characterization of a recombinant canine coronavirus with a distinct receptor-binding (S1) domain. Virology 430(2): 90-99.
  26. Hamilton, B. S., Gludish, D. W. and Whittaker, G. R. (2012). Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificities. J Virol 86(19): 10579-10586.
  27. Costello, D. A., Lee, D. W., Drewes, J., Vasquez, K. A., Kisler, K., Wiesner, U., Pollack, L., Whittaker, G. R. and Daniel, S. (2012). Influenza virus-membrane fusion triggered by proton uncaging for single particle studies of fusion kinetics. Anal Chem 84(20): 8480-8489.
  28. Hamilton, B. S., Sun, X., Chung, C. and Whittaker, G. R. (2012). Acquisition of a novel eleven amino acid insertion directly N-terminal to a tetrabasic cleavage site confers intracellular cleavage of an H7N7 influenza virus hemagglutinin. Virology 434(1): 88-95.
  29. Belouzard, S., Millet, J. K., Licitra, B. N. and Whittaker, G. R. (2012). Mechanisms of coronavirus cell entry mediated by the viral spike protein. Viruses 4(6): 1011-1033.
  30. Hamilton, B. S., Whittaker, G. R. and Daniel, S. (2012). Influenza virus-mediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion. Viruses 4(7): 1144-1168.