Improve Research Reproducibility A Bio-protocol resource
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Yong Song Gho
  • Life Sciences Department, Pohang University of Science and Technology (POSTECH), Republic of Korea
研究方向
  • Microbiology
个人信息

Education

Ph.D. in Biochemistry and Biophysics, University of North Carolina at Chapel Hill, USA, 1997

Current Position

Associate Professor, Department of Life Sciences, Pohang University of Science and Technology (POSTECH), and Director, Pohang Center for Evaluation of Biomaterials, Republic of Korea

Publications (since 2010)

  1. Choi D. S., Kim D. K., Kim Y. K., Gho Y. S. Proteomics of extracellular vesicles: exosomes and ectosomes. Mass Spectrometry Reviews, under revision (Invited review).
  2. Jang S. C., Kim O. Y., Yoon C. M., Choi DS, Roh T. Y., Park J, Nilsson J, L?tvall J, Kim YK, Gho Y. S. (2013). Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. ACS Nano, 7(9):7698-7710. (Nanomedicine-Invitation to write an editorial: “Could bioengineered exosome-mimetic nanovesicles be an efficient strategy for the delivery of chemotherapeutics?”)
  3. Choi, D. S., Lee, J., Go, G., Kim, Y. K. and Gho, Y. S. (2013). Circulating extracellular vesicles in cancer diagnosis and monitoring: an appraisal of clinical potential. Mol Diagn Ther 17(5): 265-271.
  4. Park, K. S., Lee, J., Jang, S. C., Kim, S. R., Jang, M. H., Lotvall, J., Kim, Y. K. and Gho, Y. S. (2013). Pulmonary inflammation induced by bacteria-free outer membrane vesicles from Pseudomonas aeruginosa. Am J Respir Cell Mol Biol 49(4): 637-645.
  5. Choi, H., Lee, H., Kim, S. R., Gho, Y. S. and Lee, S. K. (2013). Epstein-Barr virus-encoded microRNA BART15-3p promotes cell apoptosis partially by targeting BRUCE. J Virol 87(14): 8135-8144.
  6. Park, J. O., Choi, D. Y., Choi, D. S., Kim, H. J., Kang, J. W., Jung, J. H., Lee, J. H., Kim, J., Freeman, M. R., Lee, K. Y., Gho, Y. S.* and Kim, K. P.* (2013). Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions. Proteomics 13(14): 2125-2134. (*co-corresponding authors).
  7. Lee, J., Lee, E. Y., Kim, S. H., Kim, D. K., Park, K. S., Kim, K. P., Kim, Y. K., Roh, T. Y. and Gho, Y. S. (2013). Staphylococcus aureus extracellular vesicles carry biologically active beta-lactamase. Antimicrob Agents Chemother 57(6): 2589-2595. (F1000 Prime Recommendations) (Introduced on MDLinx.com).
  8. Kim, D. K., Kang, B., Kim, O. Y., Choi, D. S., Lee, J., Kim, S. R., Go, G., Yoon, Y. J., Kim, J. H., Jang, S. C., Park, K. S., Choi, E. J., Kim, K. P., Desiderio, D. M., Kim, Y. K., Lotvall, J., Hwang, D. and Gho, Y. S. (2013). EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles. J Extracell Vesicles 2.
  9. Kim, Y. S., Choi, E. J., Lee, W. H., Choi, S. J., Roh, T. Y., Park, J., Jee, Y. K., Zhu, Z., Koh, Y. Y., Gho, Y. S.* and Kim, Y. K.* (2013). Extracellular vesicles, especially derived from Gram-negative bacteria, in indoor dust induce neutrophilic pulmonary inflammation associated with both Th1 and Th17 cell responses. Clin Exp Allergy 43(4): 443-454. (*co-corresponding authors) (Editor’s Choice).
  10. Kim, J. H., Yoon, Y. J., Lee, J., Choi, E. J., Yi, N., Park, K. S., Park, J., Lotvall, J., Kim, Y. K. and Gho, Y. S. (2013). Outer membrane vesicles derived from Escherichia coli up-regulate expression of endothelial cell adhesion molecules in vitro and in vivo. PLoS One 8(3): e59276.
  11. Kim, O. Y., Hong, B. S., Park, K. S., Yoon, Y. J., Choi, S. J., Lee, W. H., Roh, T. Y., Lotvall, J., Kim, Y. K. and Gho, Y. S. (2013). Immunization with Escherichia coli outer membrane vesicles protects bacteria-induced lethality via Th1 and Th17 cell responses. J Immunol 190(8): 4092-4102.
  12. Choi, D. S., Kim, D. K., Kim, Y. K. and Gho, Y. S. (2013). Proteomics, transcriptomics and lipidomics of exosomes and ectosomes. Proteomics 13(10-11): 1554-1571.
  13. Moon, H. G., Kang, C. S., Choi, J. P., Choi, D. S., Choi, H. I., Choi, Y. W., Jeon, S. G., Yoo, J. Y., Jang, M. H., Gho, Y. S. and Kim, Y. K. (2013). Acetyl salicylic acid inhibits Th17 airway inflammation via blockade of IL-6 and IL-17 positive feedback. Exp Mol Med 45: e6.
  14. Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V. C., Borras, F. E., Breakefield, X., Budnik, V., Buzas, E., Camussi, G., Clayton, A., Cocucci, E., Falcon-Perez, J. M., Gabrielsson, S., Gho, Y. S., Gupta, D., Harsha, H. C., Hendrix, A., Hill, A. F., Inal, J. M., Jenster, G., Kramer-Albers, E. M., Lim, S. K., Llorente, A., Lotvall, J., Marcilla, A., Mincheva-Nilsson, L., Nazarenko, I., Nieuwland, R., Nolte-'t Hoen, E. N., Pandey, A., Patel, T., Piper, M. G., Pluchino, S., Prasad, T. S., Rajendran, L., Raposo, G., Record, M., Reid, G. E., Sanchez-Madrid, F., Schiffelers, R. M., Siljander, P., Stensballe, A., Stoorvogel, W., Taylor, D., Thery, C., Valadi, H., van Balkom, B. W., Vazquez, J., Vidal, M., Wauben, M. H., Yanez-Mo, M., Zoeller, M. and Mathivanan, S. (2012). Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol 10(12): e1001450.
  15. Kim, J. M., Shin, H. I., Cha, S. S., Lee, C. S., Hong, B. S., Lim, S., Jang, H. J., Kim, J., Yang, Y. R., Kim, Y. H., Yun, S., Rijal, G., Lee-Kwon, W., Seo, J. K., Gho, Y. S., Ryu, S. H., Hur, E. M. and Suh, P. G. (2012). DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling. Nat Commun 3: 1296.
  16. Davies, R. T., Kim, J., Jang, S. C., Choi, E. J., Gho, Y. S. and Park, J. (2012). Microfluidic filtration system to isolate extracellular vesicles from blood. Lab Chip 12(24): 5202-5210.
  17. Choi, D. S., Choi, D. Y., Hong, B. S., Jang, S. C., Kim, D. K., Lee, J., Kim, Y. K., Kim, K. P. *and Gho, Y. S.* (2012). Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells. J Extracell Vesicles 1. (*co-corresponding authors).
  18. Kim, M. R., Hong, S. W., Choi, E. B., Lee, W. H., Kim, Y. S., Jeon, S. G., Jang, M. H., Gho, Y. S.* and Kim, Y. K.* (2012). Staphylococcus aureus-derived extracellular vesicles induce neutrophilic pulmonary inflammation via both Th1 and Th17 cell responses. Allergy 67(10): 1271-1281. (*co-corresponding authors).
  19. Choi, J. P., Kim, Y. S., Kim, O. Y., Kim, Y. M., Jeon, S. G., Roh, T. Y., Park, J. S., Gho, Y. S. and Kim, Y. K. (2012). TNF-alpha is a key mediator in the development of Th2 cell response to inhaled allergens induced by a viral PAMP double-stranded RNA. Allergy 67(9): 1138-1148.
  20. Lee, E. Y., Park, K. S., Yoon, Y. J., Lee, J., Moon, H. G., Jang, S. C., Choi, K. H., Kim, Y. K. and Gho, Y. S. (2012). Therapeutic effects of autologous tumor-derived nanovesicles on melanoma growth and metastasis. PLoS One 7(3): e33330.
  21. Cheong, S. M., Choi, H., Hong, B. S., Gho, Y. S. and Han, J. K. (2012). Dab2 is pivotal for endothelial cell migration by mediating VEGF expression in cancer cells. Exp Cell Res 318(5): 550-557.
  22. Tae, Y. M., Park, H. T., Moon, H. G., Kim, Y. S., Jeon, S. G., Roh, T. Y., Bae, Y. S., Gho, Y. S., Ryu, S. H., Kwon, H. S. and Kim, Y. K. (2012). Airway activation of formyl peptide receptors inhibits Th1 and Th17 cell responses via inhibition of mediator release from immune and inflammatory cells and maturation of dendritic cells. J Immunol 188(4): 1799-1808.
  23. Choi, D. S., Yang, J. S., Choi, E. J., Jang, S. C., Park, S., Kim, O. Y., Hwang, D., Kim, K. P., Kim, Y. K., Kim, S.* and Gho, Y. S.* (2012). The protein interaction network of extracellular vesicles derived from human colorectal cancer cells. J Proteome Res 11(2): 1144-1151. (*co-corresponding authors).
  24. Choi, D. S., Kim, D. K., Choi, S. J., Lee, J., Choi, J. P., Rho, S., Park, S. H., Kim, Y. K., Hwang, D.* and Gho, Y. S.* (2011). Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa. Proteomics 11(16): 3424-3429. (*co-corresponding authors).
  25. Choi, D. S., Park, J. O., Jang, S. C., Yoon, Y. J., Jung, J. W., Choi, D. Y., Kim, J. W., Kang, J. S., Park, J., Hwang, D., Lee, K. H., Park, S. H., Kim, Y. K., Desiderio, D. M., Kim, K. P.* and Gho, Y. S.* (2011). Proteomic analysis of microvesicles derived from human colorectal cancer ascites. Proteomics 11(13): 2745-2751. (*co-corresponding authors).
  26. Lee, B. J., Moon, H. G., Shin, T. S., Jeon, S. G., Lee, E. Y., Gho, Y. S., Lee, C. G., Zhu, Z., Elias, J. A. and Kim, Y. K. (2011). Protective effects of basic fibroblast growth factor in the development of emphysema induced by interferon-gamma. Exp Mol Med 43(4): 169-178.
  27. Hong, S. W., Kim, M. R., Lee, E. Y., Kim, J. H., Kim, Y. S., Jeon, S. G., Yang, J. M., Lee, B. J., Pyun, B. Y., Gho, Y. S.* and Kim, Y. K.* (2011). Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation. Allergy 66(3): 351-359. (*co-corresponding authors).
  28. Moon, H. G., Tae, Y. M., Kim, Y. S., Gyu Jeon, S., Oh, S. Y., Song Gho, Y., Zhu, Z. and Kim, Y. K. (2010). Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. Allergy 65(9): 1093-1103.
  29. Kim, Y. S., Choi, S. J., Tae, Y. M., Lee, B. J., Jeon, S. G., Oh, S. Y., Gho, Y. S., Zhu, Z. and Kim, Y. K. (2010). Distinct roles of vascular endothelial growth factor receptor-1- and receptor-2-mediated signaling in T cell priming and Th17 polarization to lipopolysaccharide-containing allergens in the lung. J Immunol 185(9): 5648-5655.
  30. Shin, T. S., Lee, B. J., Tae, Y. M., Kim, Y. S., Jeon, S. G., Gho, Y. S., Choi, D. C. and Kim, Y. K. (2010). Role of inducible nitric oxide synthase on the development of virus-associated asthma exacerbation which is dependent on Th1 and Th17 cell responses. Exp Mol Med 42(10): 721-730.
  31. Park, K. S., Choi, K. H., Kim, Y. S., Hong, B. S., Kim, O. Y., Kim, J. H., Yoon, C. M., Koh, G. Y., Kim, Y. K.* and Gho, Y. S.* (2010). Outer membrane vesicles derived from Escherichia coli induce systemic inflammatory response syndrome. PLoS One 5(6): e11334. (*co-corresponding authors).
  32. Kim, Y. S., Choi, S. J., Choi, J. P., Jeon, S. G., Oh, S., Lee, B. J., Gho, Y. S., Lee, C. G., Zhu, Z., Elias, J. A. and Kim, Y. K. (2010). IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model. Exp Mol Med 42(8): 533-546.
  33. Kim, J. W., Kim, T. D., Hong, B. S., Kim, O. Y., Yoon, W. H., Chae, C. B. and Gho, Y. S. (2010). A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity. Exp Mol Med 42(7): 514-523.
  34. Lee, H. M., Choi, E. J., Kim, J. H., Kim, T. D., Kim, Y. K., Kang, C. and Gho, Y. S. (2010). A membranous form of ICAM-1 on exosomes efficiently blocks leukocyte adhesion to activated endothelial cells. Biochem Biophys Res Commun 397(2): 251-256.
  35. Choi, J. P., Kim, Y. S., Tae, Y. M., Choi, E. J., Hong, B. S., Jeon, S. G., Gho, Y. S., Zhu, Z. and Kim, Y. K. (2010). A viral PAMP double-stranded RNA induces allergen-specific Th17 cell response in the airways which is dependent on VEGF and IL-6. Allergy 65(10): 1322-1330.
  36. Shin, T. S., Kim, J. H., Kim, Y. S., Jeon, S. G., Zhu, Z., Gho, Y. S.* and Kim, Y. K.* (2010). Extracellular vesicles are key intercellular mediators in the development of immune dysfunction to allergens in the airways. Allergy 65(10): 1256-1265. (*co-corresponding authors).
  37. Moon, H. G., Kim, Y. S., Choi, J. P., Choi, D. S., Yoon, C. M., Jeon, S. G., Gho, Y. S.* and Kim, Y. K.* (2010). Aspirin attenuates the anti-inflammatory effects of theophylline via inhibition of cAMP production in mice with non-eosinophilic asthma. Exp Mol Med 42(1): 47-60. (*co-corresponding authors).
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