Satoshi Nakajima
  • Microbiology and Molecular Genetics, University of Pittsburgh, USA
研究方向
  • Cell biology
个人信息

Education

Ph.D., Tohoku University, 2000

Current position

Assistant Professor, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh

Publications (since 2003)

  1. Nakajima, S.*, Lan, L., Wei, L., Hsieh, C. L., Rapic-Otrin, V., Yasui, A. and Levine, A. S. (2014). Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks. PLoS One 9(1): e84899. (*Co-respondence)
  2. Lan, L.**, Nakajima, S.*, Wei, L.*, Sun, L., Hsieh, C. L., Sobol, R. W., Bruchez, M., Van Houten, B., Yasui, A. and Levine, A. S. (2014). Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin. Nucleic Acids Res 42(4): 2330-2345. (*Co-first, **Co-respondence)
  3. Xu, L., Chen, Y.-C., Nakajima, S., Chong, J., Wang, L., Lan, L., Zhang, C. and Wang, D. (2014). A chemical probe targets DNA 5-formylcytosine sites and inhibits TDG excision, polymerases bypass, and gene expression. Chemical Science 5(2): 567-574.
  4. Benitez, A., Yuan, F., Nakajima, S., Wei, L., Qian, L., Myers, R., Hu, J. J., Lan, L. and Zhang, Y. (2014). Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein. Nucleic Acids Res 42(3): 1671-1683.
  5. Ui, A., Ogiwara, H., Nakajima, S., Kanno, S., Watanabe, R., Harata, M., Okayama, H., Harris, C. C., Yokota, J., Yasui, A. and Kohno, T. (2014). Possible involvement of LKB1-AMPK signaling in non-homologous end joining. Oncogene 33(13): 1640-1648.
  6. Wei, L., Nakajima, S., Hsieh, C. L., Kanno, S., Masutani, M., Levine, A. S., Yasui, A. and Lan, L. (2013). Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose). J Cell Sci 126(Pt 19): 4414-4423.
  7. Lan, L., Nakajima, S.*, Kapetanaki, M. G., Hsieh, C. L., Fagerburg, M., Thickman, K., Rodriguez-Collazo, P., Leuba, S. H., Levine, A. S. and Rapic-Otrin, V. (2012). Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase. J Biol Chem 287(15): 12036-12049. (*Co-first author)
  8. Zlatanou, A., Despras, E., Braz-Petta, T., Boubakour-Azzouz, I., Pouvelle, C., Stewart, G. S., Nakajima, S., Yasui, A., Ishchenko, A. A. and Kannouche, P. L. (2011). The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol eta in response to oxidative DNA damage in human cells. Mol Cell 43(4): 649-662.
  9. Ogiwara, H., Ui, A., Otsuka, A., Satoh, H., Yokomi, I., Nakajima, S., Yasui, A., Yokota, J. and Kohno, T. (2011). Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors. Oncogene 30(18): 2135-2146.
  10. Lan, L., Ui, A., Nakajima, S., Hatakeyama, K., Hoshi, M., Watanabe, R., Janicki, S. M., Ogiwara, H., Kohno, T., Kanno, S. and Yasui, A. (2010). The ACF1 complex is required for DNA double-strand break repair in human cells. Mol Cell 40(6): 976-987.
  11. Ziv, O., Geacintov, N., Nakajima, S., Yasui, A. and Livneh, Z. (2009). DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients. Proc Natl Acad Sci U S A 106(28): 11552-11557.
  12. Petta, T. B., Nakajima, S., Zlatanou, A., Despras, E., Couve-Privat, S., Ishchenko, A., Sarasin, A., Yasui, A. and Kannouche, P. (2008). Human DNA polymerase iota protects cells against oxidative stress. EMBO J 27(21): 2883-2895.
  13. Hong, Z., Jiang, J., Lan, L., Nakajima, S., Kanno, S., Koseki, H. and Yasui, A. (2008). A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell. Nucleic Acids Res 36(9): 2939-2947.
  14. Kanno, S., Kuzuoka, H., Sasao, S., Hong, Z., Lan, L., Nakajima, S. and Yasui, A. (2007). A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. EMBO J 26(8): 2094-2103.
  15. Kamath-Loeb, A. S., Lan, L., Nakajima, S., Yasui, A. and Loeb, L. A. (2007). Werner syndrome protein interacts functionally with translesion DNA polymerases. Proc Natl Acad Sci U S A 104(25): 10394-10399.
  16. Nakajima, S., Lan, L., Kanno, S., Usami, N., Kobayashi, K., Mori, M., Shiomi, T. and Yasui, A. (2006). Replication-dependent and -independent responses of RAD18 to DNA damage in human cells. J Biol Chem 281(45): 34687-34695.
  17. Lo, H. L., Nakajima, S., Ma, L., Walter, B., Yasui, A., Ethell, D. W. and Owen, L. B. (2005). Differential biologic effects of CPD and 6-4PP UV-induced DNA damage on the induction of apoptosis and cell-cycle arrest. BMC Cancer 5: 135.
  18. Lan, L., Nakajima, S., Komatsu, K., Nussenzweig, A., Shimamoto, A., Oshima, J. and Yasui, A. (2005). Accumulation of Werner protein at DNA double-strand breaks in human cells. J Cell Sci 118(Pt 18): 4153-4162.
  19. Jans, J., Schul, W., Sert, Y. G., Rijksen, Y., Rebel, H., Eker, A. P., Nakajima, S., van Steeg, H., de Gruijl, F. R., Yasui, A., Hoeijmakers, J. H. and van der Horst, G. T. (2005). Powerful skin cancer protection by a CPD-photolyase transgene. Curr Biol 15(2): 105-115.
  20. Nakajima, S., Lan, L., Kanno, S., Takao, M., Yamamoto, K., Eker, A. P. and Yasui, A. (2004). UV light-induced DNA damage and tolerance for the survival of nucleotide excision repair-deficient human cells. J Biol Chem 279(45): 46674-46677.
  21. Lan, L., Nakajima, S., Oohata, Y., Takao, M., Okano, S., Masutani, M., Wilson, S. H. and Yasui, A. (2004). In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Proc Natl Acad Sci U S A 101(38): 13738-13743.
  22. Lan, L., Hayashi, T., Rabeya, R. M., Nakajima, S., Kanno, S., Takao, M., Matsunaga, T., Yoshino, M., Ichikawa, M., Riele, H., Tsuchiya, S., Tanaka, K. and Yasui, A. (2004). Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells. DNA Repair (Amst) 3(2): 135-143.
  23. Hirouchi, T., Nakajima, S., Najrana, T., Tanaka, M., Matsunaga, T., Hidema, J., Teranishi, M., Fujino, T., Kumagai, T. and Yamamoto, K. (2003). A gene for a Class II DNA photolyase from Oryza sativa: cloning of the cDNA by dilution-amplification. Mol Genet Genomics 269(4): 508-516.
  24. Fitch, M. E., Nakajima, S., Yasui, A. and Ford, J. M. (2003). In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product. J Biol Chem 278(47): 46906-46910.