YB
Yenan T. Bryceson
  • Department of Medicine, Center for Infectious Medicine/Karolinska Institute, Sweden
研究方向
  • Microbiology
个人信息

Education

Ph.D., Department of Medicine, Karolinska Institutet (KI), Sweden, 2008
Supported by National Institutes of Health (NIH), Bethesda, MD, USA through NIH-KI Graduate Partnership Program (six years spent full-time at NIH)

Current position

Professor II, Department of Clinical Sciences, University of Bergen, Norway (since 2012)
Assitant Professor, Department of Medicine, Karolinska Institutet, Sweden (since 2011)

Publications

List of peer reviewed publications
Bibliometry citations 1926/2942 (ISI/Google Scholar) and H-index 24/27 (ISI/Google Scholar)

Selected, original peer-reviewed articles

  1. Cichocki, F., Schlums, H., Li, H., Stache, V., Holmes, T., Lenvik, T. R., Chiang, S. C., Miller, J. S., Meeths, M., Anderson, S. K. and Bryceson, Y. T. (2014). Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency. J Exp Med 211(6): 1079-1091.
  2. Borte, S., Meeths, M., Liebscher, I., Krist, K., Nordenskjold, M., Hammarstrom, L., von Dobeln, U., Henter, J. I. and Bryceson, Y. T. (2014). Combined newborn screening for familial hemophagocytic lymphohistiocytosis and severe T- and B-cell immunodeficiencies. J Allergy Clin Immunol. (Epub ahead of print)
  3. Theorell, J., Gustavsson, A. L., Tesi, B., Sigmundsson, K., Ljunggren, H. G., Lundback, T. and Bryceson, Y. T. (2014). Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation. Cancer Immunol Immunother 63(6): 627-641.
  4. Muller, M. L., Chiang, S. C., Meeths, M., Tesi, B., Entesarian, M., Nilsson, D., Wood, S. M., Nordenskjold, M., Henter, J. I., Naqvi, A. and Bryceson, Y. T. (2014). An N-Terminal Missense Mutation in STX11 Causative of FHL4 Abrogates Syntaxin-11 Binding to Munc18-2. Front Immunol 4: 515.
  5. Dickinson, R. E., Milne, P., Jardine, L., Zandi, S., Swierczek, S. I., McGovern, N., Cookson, S., Ferozepurwalla, Z., Langridge, A., Pagan, S., Gennery, A., Heiskanen-Kosma, T., Hamalainen, S., Seppanen, M., Helbert, M., Tholouli, E., Gambineri, E., Reykdal, S., Gottfreethsson, M., Thaventhiran, J. E., Morris, E., Hirschfield, G., Richter, A. G., Jolles, S., Bacon, C. M., Hambleton, S., Haniffa, M., Bryceson, Y., Allen, C., Prchal, J. T., Dick, J. E., Bigley, V. and Collin, M. (2014). The evolution of cellular deficiency in GATA2 mutation. Blood 123(6): 863-874.
  6. Hagberg, N., Theorell, J., Schlums, H., Eloranta, M. L., Bryceson, Y. T. and Ronnblom, L. (2013). Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56(dim) NK cells. J Immunol 191(6): 2989-2998.
  7. Hagberg, N., Theorell, J., Eloranta, M. L., Pascal, V., Bryceson, Y. T. and Ronnblom, L. (2013). Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus. Rheumatology (Oxford) 52(10): 1818-1823.
  8. Cohnen, A., Chiang, S. C., Stojanovic, A., Schmidt, H., Claus, M., Saftig, P., Janssen, O., Cerwenka, A., Bryceson, Y. T. and Watzl, C. (2013). Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage. Blood 122(8): 1411-1418.
  9. Chiang, S. C., Theorell, J., Entesarian, M., Meeths, M., Mastafa, M., Al-Herz, W., Frisk, P., Gilmour, K. C., Ifversen, M., Langenskiold, C., Machaczka, M., Naqvi, A., Payne, J., Perez-Martinez, A., Sabel, M., Unal, E., Unal, S., Winiarski, J., Nordenskjold, M., Ljunggren, H. G., Henter, J. I. and Bryceson, Y. T. (2013). Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production. Blood 121(8): 1345-1356.
  10. Bryceson, Y. T., Pende, D., Maul-Pavicic, A., Gilmour, K. C., Ufheil, H., Vraetz, T., Chiang, S. C., Marcenaro, S., Meazza, R., Bondzio, I., Walshe, D., Janka, G., Lehmberg, K., Beutel, K., zur Stadt, U., Binder, N., Arico, M., Moretta, L., Henter, J. I. and Ehl, S. (2012). A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes. Blood 119(12): 2754-2763.
  11. Meeths, M., Chiang, S. C., Wood, S. M., Entesarian, M., Schlums, H., Bang, B., Nordenskjold, E., Bjorklund, C., Jakovljevic, G., Jazbec, J., Hasle, H., Holmqvist, B. M., Rajic, L., Pfeifer, S., Rosthoj, S., Sabel, M., Salmi, T. T., Stokland, T., Winiarski, J., Ljunggren, H. G., Fadeel, B., Nordenskjold, M., Henter, J. I. and Bryceson, Y. T. (2011). Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D. Blood 118(22): 5783-5793.
  12. Jessen, B., Maul-Pavicic, A., Ufheil, H., Vraetz, T., Enders, A., Lehmberg, K., Langler, A., Gross-Wieltsch, U., Bay, A., Kaya, Z., Bryceson, Y. T., Koscielniak, E., Badawy, S., Davies, G., Hufnagel, M., Schmitt-Graeff, A., Aichele, P., Zur Stadt, U., Schwarz, K. and Ehl, S. (2011). Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome. Blood 118(17): 4620-4629.
  13. Hagberg, N., Berggren, O., Leonard, D., Weber, G., Bryceson, Y. T., Alm, G. V., Eloranta, M. L. and Ronnblom, L. (2011). IFN-alpha production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1beta and LFA-1. J Immunol 186(9): 5085-5094.
  14. Maul-Pavicic, A., Chiang, S. C., Rensing-Ehl, A., Jessen, B., Fauriat, C., Wood, S. M., Sjoqvist, S., Hufnagel, M., Schulze, I., Bass, T., Schamel, W. W., Fuchs, S., Pircher, H., McCarl, C. A., Mikoshiba, K., Schwarz, K., Feske, S., Bryceson, Y. T. and Ehl, S. (2011). ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis. Proc Natl Acad Sci U S A 108(8): 3324-3329.
  15. Henter, J. I., Palmkvist-Kaijser, K., Holzgraefe, B., Bryceson, Y. T. and Palmer, K. (2010). Cytotoxic therapy for severe swine flu A/H1N1. Lancet 376(9758): 2116.
  16. Meeths, M., Entesarian, M., Al-Herz, W., Chiang, S. C., Wood, S. M., Al-Ateeqi, W., Almazan, F., Boelens, J. J., Hasle, H., Ifversen, M., Lund, B., van den Berg, J. M., Gustafsson, B., Hjelmqvist, H., Nordenskjold, M., Bryceson, Y. T.* and Henter, J. I.* (2010). Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis type 5 patients with mutations in STXBP2. Blood 116(15): 2635-2643.
    *Equal contribution, shared senior authorship
  17. Fauriat, C., Long, E. O., Ljunggren, H. G. and Bryceson, Y. T. (2010). Regulation of human NK-cell cytokine and chemokine production by target cell recognition. Blood 115(11): 2167-2176.
  18. Kim, H. S., Das, A., Gross, C. C., Bryceson, Y. T. and Long, E. O. (2010). Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase. Immunity 32(2): 175-186.
  19. Wood, S. M., Meeths, M., Chiang, S. C., Bechensteen, A. G., Boelens, J. J., Heilmann, C., Horiuchi, H., Rosthoj, S., Rutynowska, O., Winiarski, J., Stow, J. L., Nordenskjold, M., Henter, J. I., Ljunggren, H. G. and Bryceson, Y. T. (2009). Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity. Blood 114(19): 4117-4127.
  20. Bryceson, Y. T., Ljunggren, H. G. and Long, E. O. (2009). Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors. Blood 114(13): 2657-2666.
  21. Liu, D., Bryceson, Y. T., Meckel, T., Vasiliver-Shamis, G., Dustin, M. L. and Long, E. O. (2009). Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. Immunity 31(1): 99-109.
  22. Bryceson, Y. T., Rudd, E., Zheng, C., Edner, J., Ma, D., Wood, S. M., Bechensteen, A. G., Boelens, J. J., Celkan, T., Farah, R. A., Hultenby, K., Winiarski, J., Roche, P. A., Nordenskjold, M., Henter, J. I., Long, E. O. and Ljunggren, H. G. (2007). Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients. Blood 110(6): 1906-1915.
  23. Rajagopalan, S., Bryceson, Y. T., Kuppusamy, S. P., Geraghty, D. E., van der Meer, A., Joosten, I. and Long, E. O. (2006). Activation of NK cells by an endocytosed receptor for soluble HLA-G. PLoS Biol 4(1): e9.
  24. Bryceson, Y. T., March, M. E., Ljunggren, H. G. and Long, E. O. (2006). Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood 107(1): 159-166.
  25. Bryceson, Y. T., March, M. E., Barber, D. F., Ljunggren, H. G. and Long, E. O. (2005). Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. J Exp Med 202(7): 1001-1012.
  26. Bryceson, Y. T., Torgersen, K. M., Inngjerdingen, M., Berg, S. F., Hoelsbrekken, S. E., Fossum, S. and Dissen, E. (2005). The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells. Eur J Immunol 35(4): 1230-1239.

Selected, peer-reviewed reviews

  1. Meeths, M., Chiang, S. C., Lofstedt, A., Muller, M. L., Tesi, B., Henter, J. I. and Bryceson, Y. T. (2014). Pathophysiology and spectrum of diseases caused by defects in lymphocyte cytotoxicity. Exp Cell Res 325(1): 10-17.
  2. Chiang, S. C. and Bryceson, Y. T. (2014). Measurement of NK cell phenotype and activity in humans. Microbiology’s Manual of Molecular Clinical and Laboratory Immunology. (In press)
  3. Vaiselbuh, S. R., Bryceson, Y. T., Allen, C. E., Whitlock, J. A. and Abla, O. (2014). Updates on histiocytic disorders. Pediatr Blood Cancer 61(7): 1329-1335.
  4. Cichocki, F., Sitnicka, E. and Bryceson, Y. T. (2014). NK cell development and function--plasticity and redundancy unleashed. Semin Immunol 26(2): 114-126.
  5. Bryceson, Y. T., Björkström, N. K., Mjösberg, J. and Ljunggren, H. G. Natural killer cells. The Autoimmune Diseases 5th Ed.
  6. Cichocki, F., Miller, J. S., Anderson, S. K. and Bryceson, Y. T. (2013). Epigenetic regulation of NK cell differentiation and effector functions. Front Immunol 4: 55.
  7. Wood, S. M. and Bryceson, Y. T. (2012). Lymphocyte cytotoxicity: tug-of-war on microtubules. Blood 119(17): 3873-3875.
  8. Wood, S. M., Ljunggren, H. G. and Bryceson, Y. T. (2011). Insights into NK cell biology from human genetics and disease associations. Cell Mol Life Sci 68(21): 3479-3493.
  9. Bryceson, Y. T., Chiang, S. C., Darmanin, S., Fauriat, C., Schlums, H., Theorell, J. and Wood, S. M. (2011). Molecular mechanisms of natural killer cell activation. J Innate Immun 3(3): 216-226.
  10. Flodstrom-Tullberg, M., Bryceson, Y. T., Shi, F. D., Hoglund, P. and Ljunggren, H. G. (2009). Natural killer cells in human autoimmunity. Curr Opin Immunol 21(6): 634-640.
  11. Bryceson, Y. T. and Ljunggren, H. G. (2008). Tumor cell recognition by the NK cell activating receptor NKG2D. Eur J Immunol 38(11): 2957-2961.
  12. Bryceson, Y. T. and Ljunggren, H. G. (2008). Arrestin NK cell cytotoxicity. Nat Immunol 9(8): 835-836.
  13. Bryceson, Y. T. and Long, E. O. (2008). Line of attack: NK cell specificity and integration of signals. Curr Opin Immunol 20(3): 344-352.
  14. Bryceson, Y. T., March, M. E., Ljunggren, H. G. and Long, E. O. (2006). Activation, coactivation, and costimulation of resting human natural killer cells. Immunol Rev 214: 73-91.