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Melissa H Brown
  • School of Biological Sciences, Flinders University, Australia
研究方向
  • Microbiology
个人信息

Education

Ph.D. in Microbiology, University of Adelaide, South Australia Australia, 1992

Current position

Professor in Microbiology, Flinders University, South Australia

Publications (since 2005)

  1. Li, L., Hassan, K. A., Brown, M. H. and Paulsen, I. T. (2016). Rapid multiplexed phenotypic screening identifies drug resistance functions for three novel efflux pumps in Acinetobacter baumannii. J Antimicrob Chemother 71(5): 1223-1232.
  2. Chen, M. M. S., Boardman, W. S. J., Smith, I., Goodman, A. E. and Brown, M. H. (2015). Characterisation of -lactam resistance mediated by blaZ in staphylococci recovered from captive and wild wallabies. Journal of Global Antibiotic Resistance 3:184-189.
  3. Giles, S. K., Eijkelkamp, B. A., Stroeher, U. H. and Brown, M. H. (2015). Identification of genes involved in pellicle formation in Acinetobacter baumannii ATCC 17978. BMC Microbiology 15:116.
  4. Antiabong, J. F., Ball, A. S. and Brown, M. H. (2015). The effects of iron limitation and cell density on prokaryotic metabolism and gene expression: Excerpts from Fusobacterium necrophorum strain 774 (sheep isolate). Gene 563(1): 94-102.
  5. Iscla, I., Wray, R., Blount, P., Larkins-Ford, J., Conery, A. L., Ausubel, F. M., Ramu, S., Kavanagh, A., Huang, J. X., Blaskovich, M. A., Cooper, M. A., Obregon-Henao, A., Orme, I., Tjandra, E. S., Stroeher, U. H., Brown, M. H., Macardle, C., van Holst, N., Ling Tong, C., Slattery, A. D., Gibson, C. T., Raston, C. L. and Boulos, R. A. (2015). A new antibiotic with potent activity targets MscL. J Antibiot (Tokyo) 68(7): 453-462.
  6. Tong, C. L., Stroeher, U. H., Brown, M. H. and Raston, C. L. (2015). Continuous flow vortex fluidic synthesis of silica xerogel as a delivery vehicle for curcumin. RSC Advances 5:7953-7958.
  7. Leterme, S. C., Jendyk, J-G., Ellis, A. V., Brown, M. H. and Kildea, T. (2014). Annual phytoplankton dynamics in the Gulf Saint Vincent, South Australian, in 2011. Oceanologia 56:757-778.
  8. Jendyk, J-G., Hemraj, D. A., Brown, M. H., Ellis, A. V. and Leterme, S. C. (2014). Environmental variability and phytoplankton dynamics in a South Australian inverse estuary. Continental Shelf Research.
  9. Eijkelkamp, B. A., Stroeher, U. H., Hassan, K. A., Paulsen, I. T. and Brown, M. H. (2014). Comparative analysis of surface-exposed virulence factors of Acinetobacter baumannii. BMC Genomics 15: 1020.
  10. Fluman, N., Adler, J., Rotenberg, S. A., Brown, M. H. and Bibi, E. (2014). Export of a single drug molecule in two transport cycles by a multidrug efflux pump. Nat Commun 5: 4615.
  11. Chen, M. M. S., Boardman, W..S..J., Smith, I., Goodman, A.E. and Brown, M. H. (2014). Nasal colonisation of Staphylococcus spp among captive and free-ranging wallabies in South Australia. Journal of Veterinary Science and Medical Diagnosis 3:2.
  12. Balzano, S., Le Lan C., Ellis, A. V., Compass, H., Newton, K., Jamieson, T., Brown, M. H. and Leterme, S. C. (2014). Evaluation of transparent exopolymer particles and microbial communities found post UV-light, multimedia and cartridge filtration pre-treatment in a SWRO plant. Desalination and Water Treatment.
  13. Hassan, K. A., Jackson, S. M., Penesyan, A., Patching, S. G., Tetu, S. G., Eijkelkamp, B. A., Brown, M. H., Henderson, P. J. and Paulsen, I. T. (2013). Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins. Proc Natl Acad Sci U S A 110(50): 20254-20259.
  14. Antiabong, J. F., Boardman, W., Adetutu, E. M., Brown, M. H. and Ball, A. S. (2013). Does anaerobic bacterial antibiosis decrease fungal diversity in oral necrobacillosis disease? Res Vet Sci 95(3): 1012-1020.
  15. Antiabong, J. F., Boardman, W., Smith, I., Brown, M. H., Ball, A. and Goodman, A. E. (2013). Detection of Fusobacterium necrophorum leukotoxin (lkta) gene sequence in the oral cavity of captive macropods. Journal of Veterinary Science and Medical Diagnosis 2:2.
  16. Antiabong, J. F., Boardman, W., Moore, R. B., Brown, M. H. and Ball, A. S. (2013). The oral microbial community of gingivitis and lumpy jaw in captive macropods. Res Vet Sci 95(3): 996-1005.
  17. Smith, R. J., Jeffries, T. C., Roudnew, B., Speck, P. G., Fitch, A. J., Seymour, J. R., Newton, K., Brown, M. H. and Mitchell, J. G. (2013). Confined aquifers as viral reservoirs. Environmental Microbiology Reports. 5:725-730.
  18. Antiabong, J. F., Jardine, D., Boardman, W., Brown, M. H. and Ball, A. S. (2013). A molecular ecological approach to the detection and designation of the etiological agents of a model polymicrobial disease. J Vet Diagn Invest 25(4): 467-472.
  19. Eijkelkamp, B. A., Stroeher, U. H., Hassan, K. A., Elbourne, L. D., Paulsen, I. T. and Brown, M. H. (2013). H-NS plays a role in expression of Acinetobacter baumannii virulence features. Infect Immun 81(7): 2574-2583.
  20. Farrugia, D. N., Elbourne, L. D., Hassan, K. A., Eijkelkamp, B. A., Tetu, S. G., Brown, M. H., Shah, B. S., Peleg, A. Y., Mabbutt, B. C. and Paulsen, I. T. (2013). The complete genome and phenome of a community-acquired Acinetobacter baumannii. PLoS One 8(3): e58628.
  21. Antiabong, J. F., Boardman, W., Smith, I., Brown, M. H., Ball, A. S. and Goodman, A. E. (2013). A molecular survey of a captive wallaby population for periodontopathogens and the co-incidence of Fusobacterium necrophorum subspecies necrophorum with periodontal diseases. Vet Microbiol 163(3-4): 335-343.
  22. La Vars, S. M., Johnston, M. R., Hayles, J., Gascooke, J. R., Brown, M. H., Leterme, S. C. and Ellis, A. V. (2013). 29Si{1H} CP-MAS NMR comparison and ATR-FTIR spectroscopic analysis of the diatoms Chaetoceros muelleri and Thalassiosira pseudonana grown at different salinities. Anal Bioanal Chem 405(10): 3359-3365.
  23. Antiabong, J. F., Boardman, W., Smith, I., Brown, M. H., Ball, A. S. and Goodman, A. E. (2013). "Cycliplex PCR" confirmation of Fusobacterium necrophorum isolates from captive wallabies: a rapid and accurate approach. Anaerobe 19: 44-49.
  24. Leterme, S. C., Prime, E., Mitchell, J., Brown, M. H. and Ellis, A. V. (2013). Diatom adaptability to environmental change: a case study of two Cocconeis species from high-salinity areas. Diatom Research 28:29-35.
  25. Smith, R. J., Jeffries, T. C., Roudnew, B., Fitch, A. J., Seymour, J. R., Delpin, M. W., Newton, K., Brown, M. H. and Mitchell, J. G. (2012). Metagenomic comparison of microbial communities inhabiting confined and unconfined aquifer ecosystems. Environ Microbiol 14(1): 240-253.
  26. Eijkelkamp, B. A., Stroeher, U. H., Hassan, K. A., Papadimitrious, M. S., Paulsen, I. T. and Brown, M. H. (2011). Adherence and motility characteristics of clinical Acinetobacter baumannii isolates. FEMS Microbiol Lett 323(1): 44-51.
  27. Baltzer, S. A. and Brown, M. H. (2011). Antimicrobial peptides: promising alternatives to conventional antibiotics. J Mol Microbiol Biotechnol 20(4): 228-235.
  28. Eijkelkamp, B. A., Hassan, K. A., Paulsen, I. T. and Brown, M. H. (2011). Development of a high-throughput cloning strategy for characterization of Acinetobacter baumannii drug transporter proteins. J Mol Microbiol Biotechnol 20(4): 211-219.
  29. Hassan, K. A., Brzoska, A. J., Wilson, N. L., Eijkelkamp, B. A., Brown, M. H. and Paulsen, I. T. (2011). Roles of DHA2 family transporters in drug resistance and iron homeostasis in Acinetobacter spp. J Mol Microbiol Biotechnol 20(2): 116-124.
  30. Eijkelkamp, B. A., Hassan, K. A., Paulsen, I. T. and Brown, M. H. (2011). Investigation of the human pathogen Acinetobacter baumannii under iron limiting conditions. BMC Genomics 12: 126.
  31. Peters, K. M., Brooks, B. E., Schumacher, M. A., Skurray. R. A. Brennan, R. G. and Brown, M. H. (2011). A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. PLoS ONE 6:e15974
  32. Merlino, J. and Brown, M. H. (2010). Biocides in the health industry. Microbiology Australia 31:158
  33. Hassan, K. A., Baltzer, S. A., Paulsen, I. T. and Brown, M. H. (2010). Pumping out biocides- cause for concern. Microbiology Australia 31:178-181.
  34. Ni, L., Jensen, S. O., Ky Tonthat, N., Berg, T., Kwong, S. M., Guan, F. H., Brown, M. H., Skurray, R. A., Firth, N. and Schumacher, M. A. (2009). The Staphylococcus aureus pSK41 plasmid-encoded ArtA protein is a master regulator of plasmid transmission genes and contains a RHH motif used in alternate DNA-binding modes. Nucleic Acids Res 37(20): 6970-6983.
  35. Peters, K. M., Sharbeen, G., Theis, T., Skurray, R. A. and Brown, M. H. (2009). Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription. Biochemistry 48(41): 9794-9800.
  36. Ho, A. Y. Y., Day, D. A. Brown, M. H. and Marc, J. (2009). Arabidopsis phospholipase Dδ: initiator of cytoskeleton-mediated signalling to fundamental cellular processes. Functional Plant Biology 36:1-9.
  37. Hassan, K. A., Xu, Z., Watkins, R. E., Brennan, R. G., Skurray, R. A. and Brown, M. H. (2009). Optimized production and analysis of the staphylococcal multidrug efflux protein QacA. Protein Expr Purif 64(2): 118-124.
  38. Wu, J., Hassan, K. A., Skurray, R. A. and Brown, M. H. (2008). Functional analyses reveal an important role for tyrosine residues in the staphylococcal multidrug efflux protein QacA. BMC Microbiol 8: 147.
  39. Peters, K. M., Schuman, J. T., Skurray, R. A., Brown, M. H., Brennan, R. G. and Schumacher, M. A. (2008). QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization. Biochemistry 47(31): 8122-8129.
  40. Hassan, K. A., Souhani, T., Skurray, R. A. and Brown, M. H. (2008). Analysis of tryptophan residues in the staphylococcal multidrug transporter QacA reveals long-distance functional associations of residues on opposite sides of the membrane. J Bacteriol 190(7): 2441-2449.
  41. Hassan, K. A., Skurray, R. A. and Brown, M. H. (2007). Transmembrane helix 12 of the Staphylococcus aureus multidrug transporter QacA lines the bivalent cationic drug binding pocket. J Bacteriol 189(24): 9131-9134.
  42. Theis, T., Skurray, R. A. and Brown, M. H. (2007). Identification of suitable internal controls to study expression of a Staphylococcus aureus multidrug resistance system by quantitative real-time PCR. J Microbiol Methods 70(2): 355-362.
  43. Hassan, K. A., Skurray, R. A. and Brown, M. H. (2007). Active export proteins mediating drug resistance in staphylococci. J Mol Microbiol Biotechnol 12(3-4): 180-196.
  44. Hassan, K. A., Robinson, K. L., Smith, A. N., Gibson, J. H., Skurray, R. A. and Brown, M. H. (2006). Glycine-rich transmembrane helix 10 in the staphylococcal tetracycline transporter TetA(K) lines a solvent-accessible channel. Biochemistry 45(51): 15661-15669.
  45. Hassan, K. A., Galea, M., Wu, J., Mitchell, B. A., Skurray, R. A. and Brown, M. H. (2006). Functional effects of intramembranous proline substitutions in the staphylococcal multidrug transporter QacA. FEMS Microbiol Lett 263(1): 76-85.
  46. Saidijam, M., Benedetti, G., Ren, Q., Xu, Z., Hoyle, C. J., Palmer, S. L., Ward, A., Bettaney, K. E., Szakonyi, G., Meuller, J., Morrison, S., Pos, M. K., Butaye, P., Walravens, K., Langton, K., Herbert, R. B., Skurray, R. A., Paulsen, I. T., O'Reilly, J., Rutherford, N. G., Brown, M. H., Bill, R. M. and Henderson, P. J. (2006). Microbial drug efflux proteins of the major facilitator superfamily. Curr Drug Targets 7(7): 793-811.
  47. Bayer, A. S., Kupferwasser, L. I., Brown, M. H., Skurray, R. A., Grkovic, S., Jones, T., Mukhopadhay, K. and Yeaman, M. R. (2006). Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity. Antimicrob Agents Chemother 50(7): 2448-2454.
  48. Xu, Z., O'Rourke, B. A., Skurray, R. A. and Brown, M. H. (2006). Role of transmembrane segment 10 in efflux mediated by the staphylococcal multidrug transport protein QacA. J Biol Chem 281(2): 792-799.

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