1:Nishina T*, Deguchi Y, Kawauchi M, Xiyu C, Yamazaki S, Mikami T, Nakano H*. Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice. iScience. 2023 Jan 5;26(2):105934. (*; co-correspondence)

2: Yamazaki S., Inohara N., Ohmuraya M., Tsuneoka Y., Yagita H., Katagiri T., Nishina T., Mikami T., Funato H., Araki K., Nakano H., IκBζ controls IL-17-triggered gene expression program in intestinal epithelial cells that restricts colonization of SFB and prevents Th17-associated pathologies.
Mucosal immunology, 2022


3: Nishina T*, Deguchi Y, Ohshima D, Takeda W, Ohtsuka M, Shichino S, Ueha S, Yamazaki S, Kawauchi M, Nakamura E, Nishiyama C, Kojima Y, Adachi-Akahane S, Hasegawa M, Nakayama M, Oshima M, Yagita H, Shibuya K, Mikami T, Inohara N, Matsushima K, Tada N, Nakano H. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021 Apr 16;12(1):2281. doi: 10.1038/s41467-021-22450-3. PMID: 33863879; PMCID: PMC8052408.

4: Takeda W., Nishina T*, Deguchi Y., Kawauchi M., Mikami T., Yagita H., Nishiyama C., Nakano H. Stromal fibroblasts produce interleukin 11 in the colon of TNBS-treated mice.
Toho J. Med., 6 (3), 111-120, 2020.


5: Kojima Y, Nishina T, Nakano H, Okumura K, Takeda K. Inhibition of Importin β1 Augments the Anticancer Effect of Agonistic Anti-Death Receptor 5 Antibody in TRAIL-resistant Tumor Cells. Mol Cancer Ther. 2020 May;19(5):1123-1133. doi: 10.1158/1535-7163.MCT-19-0597. Epub 2020 Mar 10. PMID: 32156787.

6: Shindo R, Katagiri T, Komazawa-Sakon S, Ohmuraya M, Takeda W, Nakagawa Y, Nakagata N, Sakuma T, Yamamoto T, Nishiyama C, Nishina T, Yamazaki S, Kameda H, Nakano H. Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice. Biochem Biophys Rep. 2020 Feb 7;21:100738. doi: 10.1016/j.bbrep.2020.100738. PMID: 32072024; PMCID: PMC7016002.

7: Katagiri T, Yamazaki S, Fukui Y, Aoki K, Yagita H, Nishina T, Mikami T, Katagiri S, Shiraishi A, Kimura S, Tateda K, Sumimoto H, Endo S, Kameda H, Nakano H. JunB plays a crucial role in development of regulatory T cells by promoting IL-2 signaling. Mucosal Immunol. 2019 Sep;12(5):1104-1117. doi: 10.1038/s41385-019-0182-0. Epub 2019 Jul 8. PMID: 31285535.

8: Shindo R, Ohmuraya M, Komazawa-Sakon S, Miyake S, Deguchi Y, Yamazaki S, Nishina T, Yoshimoto T, Kakuta S, Koike M, Uchiyama Y, Konishi H, Kiyama H, Mikami T, Moriwaki K, Araki K, Nakano H. Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis. iScience. 2019 May 31;15:536-551. doi: 10.1016/j.isci.2019.05.011. Epub 2019 May 14. PMID: 31132747; PMCID: PMC6538961.

9: Kurosawa T, Miyoshi S, Yamazaki S, Nishina T, Mikami T, Oikawa A, Homma S, Nakano H. A murine model of acute lung injury identifies growth factors to promote tissue repair and their biomarkers. Genes Cells. 2019 Feb;24(2):112-125. doi: 10.1111/gtc.12659. Epub 2018 Dec 18. PMID: 30474194.

10: Deguchi Y, Nishina T*, Asano K, Ohmuraya M, Nakagawa Y, Nakagata N, Sakuma T, Yamamoto T, Araki K, Mikami T, Tanaka M, Nakano H. Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice. Biochem Biophys Res Commun. 2018 Oct 28;505(2):453-459. doi: 10.1016/j.bbrc.2018.09.128. Epub 2018 Sep 26. PMID: 30268501.

11: Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H. Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production. J Biol Chem. 2017 Jan 6;292(1):205 - 216. doi: 10.1074/jbc.M116.744755. Epub 2016 Nov 21. PMID: 27872193; PMCID: PMC5217680.

12: Sakata K, Araki K, Nakano H, Nishina T, Komazawa-Sakon S, Murai S, Lee GE, Hashimoto D, Suzuki C, Uchiyama Y, Notohara K, Gukovskaya AS, Gukovsky I, Yamamura KI, Baba H, Ohmuraya M. Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome. Sci Rep. 2016 Nov 15;6:37200. doi: 10.1038/srep37200. PMID: 27845447; PMCID: PMC5109027.

13: Piao X, Komazawa-Sakon S, Nishina T, Koike M, Piao JH, Ehlken H, Kurihara H, Hara M, Van Rooijen N, Schütz G, Ohmuraya M, Uchiyama Y, Yagita H, Okumura K, He YW, Nakano H. c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. Sci Signal. 2012 Dec 18;5(255):ra93. doi: 10.1126/scisignal.2003558. PMID: 23250397; PMCID: PMC4465294.

14: Nishina T, Komazawa-Sakon S, Yanaka S, Piao X, Zheng DM, Piao JH, Kojima Y, Yamashina S, Sano E, Putoczki T, Doi T, Ueno T, Ezaki J, Ushio H, Ernst M, Tsumoto K, Okumura K, Nakano H. Interleukin-11 links oxidative stress and compensatory proliferation. Sci Signal. 2012 Jan 17;5(207):ra5. doi: 10.1126/scisignal.2002056. PMID: 22253262.

15: Kojima Y, Nakayama M, Nishina T, Nakano H, Koyanagi M, Takeda K, Okumura K, Yagita H. Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells. J Biol Chem. 2011 Dec 16;286(50):43383-93. doi: 10.1074/jbc.M111.309377. Epub 2011 Oct 21. PMID: 22020938; PMCID: PMC3234854.

16: Nishina T, Yamaguchi N, Gohda J, Semba K, Inoue J. NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Oct 9;388(1):96-101. doi: 10.1016/j.bbrc.2009.07.125. Epub 2009 Jul 29. PMID: 19646419.