编委
Nafisa M. Jadavji
  • Faculty, Southern Illinois University, Carbondale
研究方向
  • Biochemistry, Cell Biology, Neuroscience
个人信息

教育背景

PhD, McGill University, Canada, 2012

实验室信息

Jadavji Lab
https://www.jadavjilab.com/

研究方向

The Jadavji laboratory investigates how the brain responds to different biological processes throughout the lifespan. More specifically, our lab studies the brain, maternal nutrition contributions to offspring neurodevelopment, neurological diseases (e.g. stroke and vascular dementia), and aging.

发表论文

2024

60. Joshi S, Currier Thomas T, Jadavji NM* (2024). The impact of increasing one-carbon metabolites on traumatic brain injury (TBI) outcome using pre-clinical models. Neural Regeneration Research: 19: 1728-33.

2023

59. Pull K, Folk R, Kang J, Jackson S, Gusek B, Esfandiarei M, Jadavji NM (2023) Maternal dietary choline deficiencies during pregnancy and lactation reduce cerebral blood flow in 3-month-old female mice offspring following ischemic stroke to the sensorimotor cortex. American Journal of Physiology – Heart and Circulatory Physiology: In press

58. Virdi S, McKee AM, Nuthi M, Jadavji NM* (2023). The role of one-carbon metabolism on healthy brain aging. Nutrients. 15: 3891. (IF =5.9) (invited)

57. Hogervorst E, Haskell-Ramsay C, Jadavji NM*. (2023). Editorial: Women in nUtrition and Brain Health. Frontiers in Nutrition. Frontiers in Nutrition. 10: 122975

56. Jadavji NM, Haelterman NA, Sud R, Antonietti A. (2023). Editorial: Reproducibility in Neuroscience. Frontiers in Integrative Neuroscience. 17: 1271818.

55. Hurley L, Jauhal J, Ille S, Pull K, Malysheva OV, Jadavji NM*. (2023). Maternal dietary deficiencies in one-carbon metabolism during early neurodevelopment result in larger damage volume, reduced neurodegeneration and neuroinflammation and changes in choline metabolites after ischemic stroke in middle-aged offspring. Nutrients. 15:1556 (IF = 6.706) (invited)

54. Yahn GB, Wasek B, Bottiglieri T, Malysheva O, Caudill MA, Jadavji NM*. (2023). A dietary vitamin B12 deficiency impairs motor function and changes neuronal survival and choline metabolism after ischemic stroke to the sensorimotor cortex in middle aged male and female mice. Nutritional Neuroscience, In Press https://doi.org/10.1080/1028415X.2023.2188639. (IF = 5.0).

53. Clementson M, Hurley L, Coonrod S, Bennett C, Marella P, Pascual AS, Pull K, Wasek B, Bottiglieri T, Malysheva O, Caudill M, Jadavji NM*. (2023). Maternal dietary deficiencies in folates or choline during pregnancy and lactation worsen stroke outcome in 3-month-old male and female mouse offspring, Neural Regeneration Research. 18:2443-2448 (IF = 6.1)

2022

52. Virdi S, Jadavji NM* (2022) The impact of maternal folates on brain development and function after birth. Metabolites 12(9): 876 (IF = 5.581) (Invited).

51 Poole J, Jasbi J, Pascual AS, North S, Kwatra N, Weissig V, Gu H, Bottiglieri T, Jadavji NM*. (2022). Ischemic stroke and dietary vitamin B12 deficiency in old-aged females impaired motor function, increased ischemic damage size, and changed metabolite profiles in brain and cecum tissue. Nutrients, 14, 2960. (IF = 6.076)

50. Shirinian M, Chen C, Ushida S, Jadavji NM*. (2022) Editorial: The Role of Epigenetics in Neuropsychiatric Disorders. Frontiers in Molecular Neuroscience, 15:985023

49. Sarabipour S+, Hainer SJ+, Furlong E+, Jadavji NM+, de Winde CM, Bielczyk N, Shah AP. (2022). Writing an effective and supportive recommendation letter. The FEBS Journal 289: 298-307. PMID: 33665964. (IF = 4.267)

48. Sarabipour S, Hainer SJ, Arslan FN, Winde CM, Furlong E, Bielczyk N, Jadavji NM, Shah AP, Davla S, Asby N. (2022) Building and sustaining mentor interactions as a mentee. The FEBS Journal:289: 1374-1384. PMID: 33818917. (IF = 4.267)

47. Rando HM, Wellhausen N Ghosh, Dattoli AA, Hu F, Lee AJ, Rafizadeh DN, Byrd JB, Qi Y, S Y, Field JM, Guebila MB, Jadavji NM, Lordan R, Shelly AN, Brueffer C, Wang J, Goel RR, Park YS COVID-19 Review Consortium, Boca SM, Gitter A, Greene CS. (2022) Identification and Development of Therapeutics for COVID-19. mSystems. 6: e000233-32

2021

46. Lordan R, Rando HM, COVID-19 Review Consortium (Jadavji NM) Greene CS. (2021). Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment. mSystems. 6: e00122-21

45. Auer S, Haelterman NA, Weissgerber TL, Erlich JC, Susilaradeya D, Julkowska M, Gazda MA, Reproducibility for Everyone Team, Schwessinger B*, Jadavji NM.* (2021) Reproducibility for everyone: a community-led initiative with global reach in reproducible research training. eLife 10: e64719 (IF = 7.080)

44. Bennett C, Green J, Ciancio M, Goral J, Pitstick L, Pytynia M, Meyer A, Kwatra N, Jadavji NM*. (2021). Dietary folic acid deficiency impacts hippocampal morphology and cortical acetylcholine metabolism in adult male and female mice. Nutritional Neuroscience: 25:2057-2065. (IF = 5.0).

43. Yahn GB, Leoncio J, Jadavji NM.* (2021) The role of dietary supplementation of one-carbon metabolism on stroke outcome. Current Opinion in Clinical Nutrition and Metabolic Care: doi: 10.1097/MCO.0000000000000743. PMID: 33631772. (IF = 1.521) (invited)

42. de Winde CM, Sarabipour S, Carignano H, Davla D, Eccles D, Hainer SJ, Haidar M, Iiangovan V, Jadavji NM, Kritsiligkou, Lee TY Olafsdottir, Symmons O. (2021). Towards inclusive funding practices for early career researchers. Journal of Science Policy and Governance, 18:1

41. Yahn GB, Abato JE, Jadavji NM*. (2021). Role of vitamin B12 deficiency in ischemic stroke risk and outcome. Neural Regeneration Research.16:470-474. PMID: 32985467. PMCID: PMC79986019. (IF = 6.1).

40. Al Rubaye H, Adamson C, Jadavji NM*. (2021). The role of maternal diet on offspring gut microbiota development. Journal of Neuroscience Research. 99:284-93. PMID: 32112450. (IF = 4.139)

2020

39. Burgess K, Bennett C, Mosnier H, Kwatra N, Bethel B, Jadavji NM*. (2020). The antioxidant role of one-carbon metabolism on stroke. Antioxidants. 90:1141 PMID: 33212887. PMCID: PMC7698340. (invited) (IF = 7.675)

38. Fernandes JD, Sarabipor A, Smith CT, Niemi NM, Jadavji NM, Kozik AJ, Holehouse AS, Pejaver V, Symmons O, Filho AWB, Haage A. (2020). Research Culture: A survey-based analysis of the academic job market. eLife. 9: e54097 PMID: 32530420. PMCID: PMC7360372. (IF = 7.551)

37. Abato JE, Moftah M, Cron GO, Smith PD, Jadavji NM*. (2020). Methylenetetrahydrofolate reductase deficiency alters cellular response after ischemic stroke in male mice. Nutritional Neuroscience. 25:558-566. PMID: 32448097 (IF = 5.0).

36. Van Benthem K, Corker C, Inoue J, Adi MN, Jadavji NM*. (2020). The changing postdoc and key predictors of satisfaction with professional training. Studies in Graduate and Postdoctoral Research. 11:123-142.

2019

35. Jadavji NM*, Mosnier H, Kelly E, Lawrence K, Cruickshank S, Stacey S, McCall A, Dhatt S, Arning E, Bottiglieri T, Smith PD. (2019) One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice. Neurobiology of Disease. 132: 104613. PMID: 31525435. (IF = 5.227)

34. Wilson LA, Murphy MSQ, Ducharme R, Denize K, Jadavji NM, Potter B, Little J, Chakraborty P, Hawken S, Wilson K. (2019). Postnatal gestational age estimation via newborn screening analysis: application and potential. Expert Review of Proteomics. 16:727-31. PMID: 31422714. PMCID: PMC6816481. (IF = 3.48) (invited)

33. Kroenberg G, Gertz K, Uhlemann R, Kirste I, An J, Jadavji NM, Schott BH, Endres M, Hellweg R, Harms C. (2019). Reduced hippocampal neurogenesis in mice deficient in apoptosis repressor with caspase recruitment domain (ARC). Neuroscience. https://doi.org/10.1016/j.neuroscience.2019.07.032 PMID: 31356897. (IF = 3.502).

32. Murray LK, Jadavji NM*.(2019). The role of B-vitamin metabolism in Parkinson’s disease onset, pathology, and mechanisms. Nutrition Research Reviews. 32: 218-230. PMID: 31303188. (IF = 4.586).

31. Moftah M, Jadavji NM*. (2019). The role of behavioral training in reducing functional impairments after stroke. Neural Regeneration Research. 14:1507-08. PMID: 31089041. PMCID:PMC 6557093. (IF = 6.1). (invited).

30. Jadavji NM*, Murray LK, Emmerson JT, Rudyk CA, Hayley S, Smith PD. (2019). A genetic deficiency in one-carbon metabolism increases oxidative stress in a mouse mode of Parkinson’s disease. Toxicological Sciences. 169:25-33. PMID: 22521626. PMCID: PMC6484892. (IF = 4.398).

29. Prieur E, Jadavji NM*. (2019). Assessing spatial working memory using the spontaneous y-maze alternation test in mice. Bio Protocols, 9:1-10. PMID: 33654968. PMCID: PMC7854095.

2018

28. Jadavji NM*, Emmerson JT, Shanmugalingam U, Willmore WG, MacFarlane AJ, Smith P. (2018). MTHFR-deficiency increases vulnerability to stroke: in vitro and in vivo. Experimental Neurology. 309:14-22. PMID: 30055159. (IF = 4.483).

27. Murray LK, Smith MJ, Jadavji NM*. (2018). Maternal over supplementation with folic acid and its impact on neurodevelopment of offspring. Nutrition Reviews. 76:708-721. PMID: 30010929. (IF = 5.54).

26. Zhang M+, Jadavji NM+*, Yoo HS, Smith PD. (2018). Human GDF-11 counteracts age-related short-term memory impairments in middle-aged mice. behavioral Brain Research, 341:45-49. PMID: 29253511. (IF = 3.002).
2017
25. Jadavji NM*. (2017). The integrated stress response is not a target for diffuse white matter injury in premature infants. Journal of Neuroscience, 37: 11772-1173. PMID: 29212946. (IF = 5.924)

24. Prieur EAK, Pjetri E, Ziesel S, Jadavji NM*. (2017) BHMT-deficiency results in brain atrophy and impairs memory in mice. Applied Physiology, Nutrition, and Metabolism, 42:1228-1231. PMID: 28715642. (IF = 3.445).

23. Emmerson JT, Murray LK, Jadavji NM*. (2017).Impact of one-carbon metabolism on neural recovery. Neural Regeneration,12: 1-2. PMID: 28852387. (invited). PMCID: PMC5558484. (IF = 6.1).

22. Jadavji NM*, Emmerson JE, Willmore WG, MacFarlane AJ, Smith PD. (2017). B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke. Neurobiology of Disease, 103:89-100. PMID: 28396257. (IF = 5.624).

21. Bahous R, Jadavji NM, Deng L, Cosin-Tomas M, Lu J, Malysheva O, Leung KY, Ho MK, Pallas M, Kaliman P, Greene NDE, Bedell BJ, Caudill MA, Rozen R. (2017). High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring. Human Molecular Genetics, 26:888-900. PMID: 28069796. PMCID: PMC5409086. (IF = 5.571).

20. Dam K, Füchtemeier M, Farr TD, Boehm-Strum P, Foddis M, Dirnagl U, Jadavji NM*. (2017). Deficiencies in methylenetetrahydrofolate reductase and dietary folic acid alter choline metabolism during chronic hypoperfusion. Behavioral Brain Research, 321:201-208. PMID: 28087280. (IF = 3.002).

2016

19. Koturbash I, Jadavji NM, Kutanzi K, Rodriguez-Juarez R, Kogosov D, Metz G, Kovalchuk, O. (2016). Fractionated low-dose exposure to ionizing Radiation Leads to DNA Damage, Epigenetic Dysregulation, and Behavioral Impairment. Environmental Epigenetics, 2:1-13. PMID: 29492301. PMCID: PMC5804539.

18. Grummisch JA, Jadavji NM, Smith PD. (2016). The pleiotropic effects of tissue plasminogen activator (tPA) in the brain: implications for stroke recovery. Neural Regeneration Research, 11: 1401-2. PMID: 27482209. PMCID: PMC5090832. (invited). (IF = 6.1).

17. Emmerson JT, Jadavji NM*. (2016). Impact of maternal folic acid deficiencies on early childhood neurological development. Journal of Pediatric Reviews, 4: e6174 (invited).

16. Shanmugalingam U, Jadavji NM, Smith PD. (2016). Role of granulocyte macrophage colony stimulating factor in regeneration of the central nervous system. Neural Regeneration Research,11: 902-903. PMID: 27482209. PMCID: PMC4962578. (IF = 6.058). (invited).

15. Grummisch JA, Jadavji NM, Smith PD. (2016). Tissue plasminogen activator promotes cell survival in vitro during early postnatal neuronal development via Janus kinase 2- and mammalian target of rapamycin-dependent mechanisms. Cellular and Molecular Neuroscience, 74: 25-33. PMID: 26995507. (IF = 3.843).

14. Theoret JK+, Jadavji NM+*, Zhang M, Smith PD. (2016). Stroke-induced expression of GM-CSF receptor following white matter damage: implications for targeted stroke therapy via activation of mTOR signaling pathway. European Journal of Neuroscience, 43:17-24. PMID: 26474338. (IF = 3.753).

2015

13. Jadavji NM, Malysheva O, Caudill MA, Rozen R. (2015). MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in hippocampus in wild-type offspring. Neuroscience, 300: 1-9. PMID: 25956258. (IF = 3.327)

12. Jadavji NM*, Wieske F, Dirgnal U, Winter C. (2015). Methylenetetrahydrfolate reductase deficiency alters levels of monoamine neurotransmitters, glutamate and gamma aminobutyric acid in brain tissue. Molecular Genetics and Metabolism and Genetics Reports, 3:1-4. PMID: 26937386.PMCID: PMC4750636.

11. Jadavji NM*, Farr TD, Lips L, Khalil A, Boehm-Sturm P, Harms C, Foddis M, Füchtemeier M, Dirnagl D. (2015). Elevated levels of homocysteine, deficiencies in folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment. Behavioural Brain Research, 283: 215-226. PMID: 2565513. (IF = 3.002).

2014

10. Jadavji NM, Bahous R, Deng L, Wang XL, Malysheva O, Caudill MA, Bedell BJ, Rozen R. (2014). A mouse model for genetic variation in methionine synthase reductase exhibits mild hyperhomocysteinemia, short-term memory impairment and biochemical changes in hippocampus. Biochemical Journal, 461:205-12. PMID: 24800750. (IF = 4.396)

2012

9. Jadavji NM, Deng L, Leclerc D, Malysheva O, Caudill MA, Bedell BJ, Rozen R. (2012). Methylenetetrahydrofolate reductase deficiency in mice impairs motor and cognitive function, with morphological and neurobiochemical changes in cerebellum and hippocampus. Molecular Genetics and Metabolism, 106:149-159 PMID: 22521626. (IF = 3.774).

2011

8. Jadavji NM, Supina RD, Metz GA. (2011). Blocking glucocorticoid and mineralocorticoid receptors neutralizes motor function impairment associated with stress. Neuroendocrinology, 94:278-90. PMID:22024815. (IF = 4.373).

2009

7. Zucchi FCR, Kirkland SW, Jadavji NM, van Waes L, Klein A, Supina R, Metz GA. (2009). Predictable stress versus unpredictable stress: a comparison in a rodent model of stroke. Behavioral Brain Research, 205:67-75. PMID: 19573561. (IF = 3.002).

6. Jadavji NM, Metz GA. (2009). Both pre- and post-treatment with experiential therapy is beneficial in 6-OHDA dopamine-depleted rat. Neuroscience, 158:373-86. PMID: 19032978. (IF = 3.327).

2008

5. Jadavji NM, Metz GA. (2008). Sex differences on skilled reaching task in response to stress and recovery from stress. Behavioral Brain Research,195:251-9. PMID: 18840472. PMCID: PMC5222625. (IF = 3.002).

4. Smith LK, Jadavji NM, Colwell KL, Perehudoff SK Metz GA. (2008). Stress and glucocorticoids accelerate dopaminergic apoptosis and exaggerate motor symptoms in a rat model of Parkinson’s disease. European Journal of Neuroscience, 27: 2133-2146. PMID: 18412632. (IF = 3.753).

2007

3. Jadavji NM, Metz GA. (2007). Experiential therapy for Parkinson’s disease. University of Lethbridge Graduate Student Association Conference Proceedings. 1:62-68.

2006

2. Jadavji NM, Kolb B, Metz GA. (2006). Enriched environment improves motor function in intact and dopamine-depleted rats: implications for Parkinson’s disease. Neuroscience, 140: 1127-1138. PMID: 1667892. (IF = 3.327).

2005

1. Metz GA, Jadavji NM and Smith LK. (2005). Modulation of motor function by stress: a novel concept of the effects of stress and corticosterone on behavior. European Journal of Neuroscience, 22: 1190-1200. PMID: 16176362. (IF = 3.753).