编委
Laxmi Narayan Mishra
  • Industry Scientist, Regeneron Pharmaceuticals, Inc, New York
研究方向
  • Biochemistry, Cell Biology, Molecular Biology, Stem Cell
个人信息

教育背景

Ph.D., JNCASR, Bangalore, India, 2013

研究方向

Linker histone H1, Histone PTMs, Nucleosome, Chromatin, Nucleosome Assembly, Chromatin Folding, Transcription, Embryonic Stem Cell

发表论文

https://scholar.google.com/citations?user=o3Vpx1AAAAAJ&hl=en&oi=ao
1. Hao F, Mishra L, Jaya P, Jones R, Hayes JJ. Identification and analysis of six phosphorylation sites within the Xenopus laevis H1.0 C-terminal domain indicate distinct effects on nucleosome structure. Mol Cell Proteomics. 2022 May 23:100250. doi: 10.1016/j.mcpro.2022.100250.

2. Marr LT, Jaya P, Mishra LN, Hayes JJ. Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin. Biochem Soc Trans. 2022 Feb 28;50(1):199-212. doi: 10.1042/BST20210959. PubMed PMID: 35166326.

3. Poulet A, Mishra LN, Téletchéa S, Hayes JJ, Jacob Y, Thiriet C, Duc C. Identification and characterization of histones in Physarum polycephalum evidence a phylogenetic vicinity of Mycetozoans to the animal kingdom. NAR Genom Bioinform. 2021 Dec;3(4):lqab107. doi: 10.1093/nargab/lqab107. eCollection 2021 Dec. PubMed PMID: 34805990; PubMed Central PMCID: PMC8600027.

4. Willcockson MA, Healton SE, Weiss CN, Bartholdy BA, Botbol Y, Mishra LN, Sidhwani DS, Wilson TJ, Pinto HB, Maron MI, Skalina KA, Toro LN, Zhao J, Lee CH, Hou H, Yusufova N, Meydan C, Osunsade A, David Y, Cesarman E, Melnick AM, Sidoli S, Garcia BA, Edelmann W, Macian F, Skoultchi AI. H1 histones control the epigenetic landscape by local chromatin compaction. Nature. 2021 Jan;589(7841):293-298. doi: 10.1038/s41586-020-3032-z. Epub 2020 Dec 9. PubMed PMID: 33299182; PubMed Central PMCID: PMC8110206.

5. Jaya P, Ranjan A, Afsana AN, Srivastava AK, Mishra LN. Omics to Understand Drought Tolerance in Plants: An Update. In: Kumar A, Shukla P, Kumar R, Patel HK, editors. Omics Technologies for Sustainable Agriculture and Global Food Security (Vol II) II ed. Singapore: Springer; 2021. Chapter 4; p.69-93. 351p.

6. Healton SE, Pinto HD, Mishra LN, Hamilton GA, Wheat JC, Swist-Rosowska K, Shukeir N, Dou Y, Steidl U, Jenuwein T, Gamble MJ, Skoultchi AI. H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14251-14258. doi: 10.1073/pnas.1920725117. Epub 2020 Jun 8. PubMed PMID: 32513732; PubMed Central PMCID: PMC7322038.

7. Mishra LN, Hayes JJ. A nucleosome-free region locally abrogates histone H1-dependent restriction of linker DNA accessibility in chromatin. J Biol Chem. 2018 Dec 14;293(50):19191-19200. doi: 10.1074/jbc.RA118.005721. Epub 2018 Oct 29. PubMed PMID: 30373774; PubMed Central PMCID: PMC6302178.

8. Mishra LN, Shalini V, Gupta N, Ghosh K, Suthar N, Bhaduri U, Rao MRS. Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements. Epigenetics Chromatin. 2018 Aug 1;11(1):43. doi: 10.1186/s13072-018-0214-0. PubMed PMID: 30068355; PubMed Central PMCID: PMC6069787.

9. Gupta N, Pentakota S, Mishra LN, Jones R, Rao MR. Identification of Posttranslational Modifications of Endogenous Chromatin Proteins From Testicular Cells by Mass Spectrometry. Methods Enzymol. 2017;586:115-142. doi: 10.1016/bs.mie.2016.09.031. PubMed PMID: 28137559.

10. Mishra LN, Pepenella S, Rogge R, Hansen JC, Hayes JJ. Acetylation Mimics Within a Single Nucleosome Alter Local DNA Accessibility In Compacted Nucleosome Arrays. Sci Rep. 2016 Oct 6;6:34808. doi: 10.1038/srep34808. PubMed PMID: 27708426; PubMed Central PMCID: PMC5052607.

11. Mishra LN, Gupta N, Rao SM. Mapping of post-translational modifications of spermatid-specific linker histone H1-like protein, HILS1. J Proteomics. 2015 Oct 14;128:218-30. doi: 10.1016/j.jprot.2015.08.001. Epub 2015 Aug 6. PubMed PMID: 26257145.

12. Naz S, Ranganathan P, Bodapati P, Shastry AH, Mishra LN, Kondaiah P. Regulation of S100A2 expression by TGF-β-induced MEK/ERK signalling and its role in cell migration/invasion. Biochem J. 2012 Oct 1;447(1):81-91. doi: 10.1042/BJ20120014. PubMed PMID: 22747445.