教育背景
Ph.D., Michigan State University, USA, 2021
实验室信息
Amalfitano Lab
研究方向
SLAMF7, ERAP1, neuroimmunology, cancer immunology
发表论文
https://scholar.google.com/citations?user=fvE9aOQAAAAJ&hl=en&oi=ao• Rastall, D.P.W., Alyaquob, F., O’Connell, P., et al., Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality. Int Immunol, 2017. 29(6): p. 277-289.
• Pepelyayeva, P., Rastall, D.P.W., Aldhamen, Y.A.A., O’Connell, P., et al., Endoplasmic Reticulum Aminopeptidase 1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis. Sci Rep 8, 12464 (2018).
• O'Connell, P., et al., SLAMF7 Is a Critical Negative Regulator of IFN-alpha-Mediated CXCL10 Production in Chronic HIV Infection. J Immunol, 2018. DOI: 10.4049/jimmunol.1800847.
• O’Connell, P., Zheng, Y., Amalfitano, A. and Aldhamen, Y. A. (2019). In vitro Infection of Primary Human Monocytes with HIV-1. Bio-protocol 9(13): e3289. DOI: 10.21769/BioProtoc.3289.
• O'Connell, P., Amalfitano, A. & Aldhamen, Y. A. SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond. Vaccines (Basel) 7, doi:10.3390/vaccines7040184 (2019).
• O'Connell, P., Aldhamen, YA. Systemic innate and adaptive immune responses to SARS-CoV-2 as it relates to other coronaviruses. Hum Vaccine Immunother. 2020 Sep 2:1-12. doi: 10.1080/21645515.2020.1802974. PMID: 32878546.
• O'Connell P, Hyslop S, Blake MK, Godbehere S, Amalfitano A, Aldhamen YA. SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment. J Immunol. 2020 Dec 7:ji2000300. doi: 10.4049/jimmunol.2000300. Epub ahead of print. PMID: 33288545.
• O'Connell P, Blake MK, Godbehere S, Aldhamen YA., Amalfitano, A. Absence of ERAP1 in B cells increases susceptibility to central nervous system autoimmunity, alters B cell biology, and mechanistically explains genetic associations between ERAP1 and multiple sclerosis. J Immunol. November 22, 2021, ji2100813; DOI: https://doi.org/10.4049/jimmunol.2100813.
• O'Connell P, Blake MK, Pepelyayeva,YP, Hyslop S, Godbehere S, Ariana M. Angarita, Cristiane Pereira-Hicks, Amalfitano A, Aldhamen YA. Adenoviral delivery of an immunomodulatory protein to the tumor microenvironment controls tumor growth. Mol Therapy Oncolytics. DOI: 10.1016/j.omto.2021.12.004. 2021. PMID: 35036523.
• Blake MK, O'Connell P, Pepelyayeva,YP, Godbehere S, Aldhamen YA, Amalfitano A. ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses. BMC Immunology. DOI: 10.1186/s12865-022-00481-9. 2022. PMID: 35246034.