Sara Cabodi
  • Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy
研究方向
  • Stem cell
个人信息

Education

Ph.D. in Human Biology, Department of Biochemistry, Biology and Genetics, University of Torino, Italy, 2001

Current position

Assistant Professor in Cell Biology, Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy

Publications (since 2005)

  1. Saoncella, S., Tassone, B., Deklic, E., Avolio, F., Jon, C., Tornillo, G., De Luca, E., Di Iorio, E., Piva, R., Cabodi, S., Turco, E., Paolo Pandolfi, P. and Calautti, E. (2014). Nuclear Akt2 Opposes Limbal Keratinocyte Stem Cell Self-Renewal by Repressing a FOXO-mTORC1 Signaling Pathway. Stem Cells 32(3): 754-769.
  2. Sharma, N., Repetto, D., Aramu, S., Grasso, S., Russo, I., Fiorentino, A., Mello-Grand, M., Cabodi, S., Singh, V., Chiorino, G., Turco, E., Stefano, P. D. and Defilippi, P. (2013). Identification of two regions in the p140Cap adaptor protein that retain the ability to suppress tumor cell properties. Am J Cancer Res 3(3): 290-301.
  3. Pincini, A., Tornillo, G., Orso, F., Sciortino, M., Bisaro, B., Leal Mdel, P., Lembo, A., Brizzi, M. F., Turco, E., De Pitta, C., Provero, P., Medico, E., Defilippi, P., Taverna, D. and Cabodi, S. (2013). Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells. Cell Cycle 12(15): 2409-2422.
  4. Tornillo, G., Elia, A. R., Castellano, I., Spadaro, M., Bernabei, P., Bisaro, B., Camacho-Leal Mdel, P., Pincini, A., Provero, P., Sapino, A., Turco, E., Defilippi, P. and Cabodi, S. (2013). p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c-Kit activity. Stem Cells 31(7): 1422-1433.
  5. Camacho Leal Mdel, P., Pincini, A., Tornillo, G., Fiorito, E., Bisaro, B., Di Luca, E., Turco, E., Defilippi, P. and Cabodi, S. (2012). p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. PLoS One 7(12): e49817.
  6. Bisaro, B., Montani, M., Konstantinidou, G., Marchini, C., Pietrella, L., Iezzi, M., Galie, M., Orso, F., Camporeale, A., Colombo, S. M., Di Stefano, P., Tornillo, G., Camacho-Leal, M. P., Turco, E., Taverna, D., Cabodi, S., Amici, A. and Defilippi, P. (2012). p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. Breast Cancer Res 14(5): R137.
  7. Di Stefano, P., Leal, M. P., Tornillo, G., Bisaro, B., Repetto, D., Pincini, A., Santopietro, E., Sharma, N., Turco, E., Cabodi, S. and Defilippi, P. (2011). The adaptor proteins p140CAP and p130CAS as molecular hubs in cell migration and invasion of cancer cells. Am J Cancer Res 1(5): 663-673.
  8. Morello, V., Cabodi, S., Sigismund, S., Camacho-Leal, M. P., Repetto, D., Volante, M., Papotti, M., Turco, E. and Defilippi, P. (2011). beta1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells. Oncogene 30(39): 4087-4096.
  9. Tornillo, G., Bisaro, B., Camacho-Leal Mdel, P., Galie, M., Provero, P., Di Stefano, P., Turco, E., Defilippi, P. and Cabodi, S. (2011). p130Cas promotes invasiveness of three-dimensional ErbB2-transformed mammary acinar structures by enhanced activation of mTOR/p70S6K and Rac1. Eur J Cell Biol 90(2-3): 237-248
  10. Cabodi, S., del Pilar Camacho-Leal, M., Di Stefano, P. and Defilippi, P. (2010). Integrin signalling adaptors: not only figurants in the cancer story. Nat Rev Cancer 10(12): 858-870.
  11. Cabodi, S., Di Stefano, P., Leal Mdel, P., Tinnirello, A., Bisaro, B., Morello, V., Damiano, L., Aramu, S., Repetto, D., Tornillo, G. and Defilippi, P. (2010). Integrins and signal transduction. Adv Exp Med Biol 674: 43-54.
  12. Cabodi, S., Tinnirello, A., Bisaro, B., Tornillo, G., del Pilar Camacho-Leal, M., Forni, G., Cojoca, R., Iezzi, M., Amici, A., Montani, M., Eva, A., Di Stefano, P., Muthuswamy, S. K., Tarone, G., Turco, E. and Defilippi, P. (2010). p130Cas is an essential transducer element in ErbB2 transformation. FASEB J 24(10): 3796-3808.
  13. Cabodi, S. and Taverna, D. (2010). Interfering with inflammation: a new strategy to block breast cancer self-renewal and progression? Breast Cancer Res 12(2): 305.
  14. Damiano, L., Di Stefano, P., Camacho Leal, M. P., Barba, M., Mainiero, F., Cabodi, S., Tordella, L., Sapino, A., Castellano, I., Canel, M., Frame, M., Turco, E. and Defilippi, P. (2010). p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation. Oncogene 29(25): 3677-3690.
  15. Cabodi, S., Morello, V., Masi, A., Cicchi, R., Broggio, C., Distefano, P., Brunelli, E., Silengo, L., Pavone, F., Arcangeli, A., Turco, E., Tarone, G., Moro, L. and Defilippi, P. (2009). Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression. J Cell Physiol 218(2): 294-303.
  16. Di Stefano, P., Damiano, L., Cabodi, S., Aramu, S., Tordella, L., Praduroux, A., Piva, R., Cavallo, F., Forni, G., Silengo, L., Tarone, G., Turco, E. and Defilippi, P. (2007). p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. EMBO J 26(12): 2843-2855.
  17. Boeri Erba, E., Matthiesen, R., Bunkenborg, J., Schulze, W. X., Di Stefano, P., Cabodi, S., Tarone, G., Defilippi, P. and Jensen, O. N. (2007). Quantitation of multisite EGF receptor phosphorylation using mass spectrometry and a novel normalization approach. J Proteome Res 6(7): 2768-2785.
  18. Cabodi, S., Tinnirello, A., Di Stefano, P., Bisaro, B., Ambrosino, E., Castellano, I., Sapino, A., Arisio, R., Cavallo, F., Forni, G., Glukhova, M., Silengo, L., Altruda, F., Turco, E., Tarone, G. and Defilippi, P. (2006). p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis. Cancer Res 66(9): 4672-4680.
  19. Defilippi, P., Di Stefano, P. and Cabodi, S. (2006). p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol 16(5): 257-263.
    Boeri Erba, E., Bergatto, E., Cabodi, S., Silengo, L., Tarone, G., Defilippi, P. and Jensen, O. N. (2005). Systematic analysis of the epidermal growth factor receptor by mass spectrometry reveals stimulation-dependent multisite phosphorylation. Mol Cell Proteomics 4(8): 1107-1121.