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Douglas D. Richman
  • University of California San Diego, USA
研究方向
  • Microbiology
个人信息

Education

M.D., Stanford University, 1970

Current position

Distinguished Professor of Pathology and Medicine (Infectious Diseases), University of California San Diego School of Medicine (2009-to date)

Publications (since 2013)

  1. Abdel-Mohsen, M., Wang, C., Strain, M. C., Lada, S. M., Deng, X., Cockerham, L. R., Pilcher, C. D., Hecht, F. M., Liegler, T., Richman, D. D., Deeks, S. G. and Pillai, S. K. (2015). Select host restriction factors are associated with HIV persistence during antiretroviral therapy. AIDS 29(4): 411-420.
  2. Carter, C. C., Wagner, G. A., Hightower, G. K., Caballero, G., Phung, P., Richman, D. D., Pond, S. L. and Smith, D. M. (2015). HIV-1 neutralizing antibody response and viral genetic diversity characterized with next generation sequencing. Virology 474: 34-40.
  3. Okulicz, J. F., Le, T. D., Agan, B. K., Camargo, J. F., Landrum, M. L., Wright, E., Dolan, M. J., Ganesan, A., Ferguson, T. M., Smith, D. M., Richman, D. D., Little, S. J., Clark, R. A., He, W. and Ahuja, S. K. (2015). Influence of the timing of antiretroviral therapy on the potential for normalization of immune status in human immunodeficiency virus 1-infected individuals. JAMA Intern Med 175(1): 88-99.
  4. Persaud, D., Patel, K., Karalius, B., Rainwater-Lovett, K., Ziemniak, C., Ellis, A., Chen, Y. H., Richman, D., Siberry, G. K., Van Dyke, R., Burchett, S., Seage III, G., Luzuriaga, K. and for the Pediatric HIV/AIDS Cohort Study (2014). Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serstattus in perinatally infected adolescents. JAMA Pediatr 168(12): 1138-46, 2014.
  5. Gianella, S., Morris, S. R., Tatro, E., Vargas, M. V., Haubrich, R. H., Daar, E. S., Dube, M. P., Richman, D. D., Little, S. J. and Smith, D. M. (2014). Virologic correlates of anti-CMV IgG levels in HIV-1-infected men. J Infect Dis 209(3): 452-456.
  6. Chaillon, A., Gianella, S., Massanella Luna, M., Little, S. J., Richman, D. D. and Mehta, S. R. (2014). A case cluster demonstrating the relationship between HLA concordance and virologic and disease outcomes in human immunodeficiency virus infection. Virology 449: 104-108.
  7. Tatro, E. T., Purnajo, I., Richman, D. D., Smith, D. M. and Gianella, S. (2014). Antibody response to Achromobacter xylosoxidans during HIV infection is associated with lower CD4 levels and increased lymphocyte activation. Clin Vaccine Immunol 21(1): 46-50.
  8. Chaillon, A., Gianella, S., Wertheim, J. O., Richman, D. D., Mehta, S. R. and Smith, D. M. (2014). HIV migration between blood and cerebrospinal fluid or semen over time. J Infect Dis 209(10): 1642-1652.
  9. Tilghman, M. W., Perez-Santiago, J., Osorio, G., Little, S. J., Richman, D. D., Mathews, W. C., Haubrich, R. H. and Smith, D. M. (2014). Community HIV-1 drug resistance is associated with transmitted drug resistance. HIV Med 15(6): 339-346.
  10. Wertheim, J. O., Leigh Brown, A. J., Hepler, N. L., Mehta, S. R., Richman, D. D., Smith, D. M. and Kosakovsky Pond, S. L. (2014). The global transmission network of HIV-1. J Infect Dis 209(2): 304-313.
  11. Wagner, G. A., Pacold, M. E., Kosakovsky Pond, S. L., Caballero, G., Chaillon, A., Rudolph, A. E., Morris, S. R., Little, S. J., Richman, D. D. and Smith, D. M. (2014). Incidence and prevalence of intrasubtype HIV-1 dual infection in at-risk men in the United States. J Infect Dis 209(7): 1032-1038.
  12. Richman, D. D. (2014). Editorial Commentary: Extending HIV drug resistance testing to low levels of plasma viremia. Clin Infect Dis 58(8): 1174-1175.
  13. Kim, E. Y., Lorenzo-Redondo, R., Little, S. J., Chung, Y. S., Phalora, P. K., Maljkovic Berry, I., Archer, J., Penugonda, S., Fischer, W., Richman, D. D., Bhattacharya, T., Malim, M. H. and Wolinsky, S. M. (2014). Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection. PLoS Pathog 10(7): e1004281.
  14. Hepler, N. L., Scheffler, K., Weaver, S., Murrell, B., Richman, D. D., Burton, D. R., Poignard, P., Smith, D. M. and Kosakovsky Pond, S. L. (2014). IDEPI: rapid prediction of HIV-1 antibody epitopes and other phenotypic features from sequence data using a flexible machine learning platform. PLoS Comput Biol 10(9): e1003842.
  15. Archin, N. M., Bateson, R., Tripathy, M. K., Crooks, A. M., Yang, K. H., Dahl, N. P., Kearney, M. F., Anderson, E. M., Coffin, J. M., Strain, M. C., Richman, D. D., Robertson, K. R., Kashuba, A. D., Bosch, R. J., Hazuda, D. J., Kuruc, J. D., Eron, J. J. and Margolis, D. M. (2014). HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat. J Infect Dis 210(5): 728-735.
  16. Gianella, S., Massanella, M., Richman, D. D., Little, S. J., Spina, C. A., Vargas, M. V., Lada, S. M., Daar, E. S., Dube, M. P., Haubrich, R. H., Morris, S. R., Smith, D. M. and California Collaborative Treatment Group, T. (2014). Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment. J Virol 88(14): 7818-7827.
  17. Richman, D. D. (2014). Editorial Commentary: Extending HIV drug resistance testing to low levels of plasma viremia. Clin Infect Dis 58(8): 1174-1175.
  18. Menéndez-Arias, L. and Richman, D. D. (2014). Editorial overview: antivirals and resistance: advances and challenges ahead. Curr Opin Virol 8: iv-vii.
  19. Cockerham, L. R., Siliciano, J. D., Sinclair, E., O'Doherty, U., Palmer, S., Yukl, S. A., Strain, M. C., Chomont, N., Hecht, F. M., Siliciano, R. F., Richman, D. D. and Deeks, S. G. (2014). CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. PLoS One 9(10): e110731.
  20. Massanella, M., Ouchi, D., Marfil, S., Llibre, J. M., Puertas, M. C., Buzon, M. J., Richman, D. D., Orna, E., Stevenson, M., Gatell, J. M., Domingo, P., Negredo, E., Martinez-Picado, J., Clotet, B. and Blanco, J. (2014). Different plasma markers of inflammation are influenced by immune recovery and cART composition or intensification in treated HIV infected individuals. PLoS One 9(12): e114142.
  21. Wang, C., Abdel-Mohsen, M., Strain, M. C., Lada, S. M., Yukl, S., Cockerham, L. R., Pilcher, C. D., Hecht, F. M., Sinclair, E., Liegler, T., Richman, D. D., Deeks, S. G. and Pillai, S. K. (2014). Decreased HIV type 1 transcription in CCR5-Delta32 heterozygotes during suppressive antiretroviral therapy. J Infect Dis 210(11): 1838-1843.
  22. Karris, M. Y., Kao, Y. T., Patel, D., Dawson, M., Woods, S. P., Vaida, F., Spina, C., Richman, D., Little, S. and Smith, D. M. (2014). Predictors of virologic response in persons who start antiretroviral therapy during recent HIV infection. AIDS 28(6): 841-849.
  23. Richman, D. D. (2014). Joep MA Lange. Antivir Ther 19(4): 325-326.
  24. Luzuriaga, K., Tabak, B., Garber, M., Chen, Y. H., Ziemniak, C., McManus, M. M., Murray, D., Strain, M. C., Richman, D. D., Chun, T. W., Cunningham, C. K. and Persaud, D. (2014). Reduced HIV reservoirs after early treatment HIV-1 proviral reservoirs decay continuously under sustained virologic control in early-treated HIV-1- infected children. J Infect Dis.
  25. Rouzioux, C., Richman, D. D. (2013). How to best measure HIV reservoirs? Curr Opin HIV Aids 8(3): 170-175.
  26. Richman, D, D, and Nathanson N. (2014). Antiviral Therapy. Viral Pathogenesis and Immunity, Third Edition, Academic Press, Amsterdam, Part IV, Chapter 20: 1-33.
  27. Wensing, A. M., Calvez, V., Günthard, H. V., Johnson, V. A., Paredes, R., Pillay, D., Schafer, R. W. and Richman, D. D. (2014). Special Contribution- 2014 Update of the Drug Resistance Mutations in HIV-1. Topics of Antiviral Medicine 22(3): 642-50.
  28. Persaud, D., Gay, H., Ziemniak, C., Chen, Y. H., Piatak, M., Jr., Chun, T. W., Strain, M., Richman, D. and Luzuriaga, K. (2013). Absence of detectable HIV-1 viremia after treatment cessation in an infant. N Engl J Med 369(19): 1828-1835.
  29. DeBoever, C., Reid, E. G., Smith, E. N., Wang, X., Dumaop, W., Harismendy, O., Carson, D., Richman, D., Masliah, E. and Frazer, K. A. (2013). Whole transcriptome sequencing enables discovery and analysis of viruses in archived primary central nervous system lymphomas. PLoS One 8(9): e73956.
  30. Stadeli, K. M. and Richman, D. D. (2013). Rates of emergence of HIV drug resistance in resource-limited settings: a systematic review. Antivir Ther 18(1): 115-123.
  31. Gianella, S., Anderson, C. M., Vargas, M. V., Richman, D. D., Little, S. J., Morris, S. R. and Smith, D. M. (2013). Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA. J Infect Dis 207(6): 898-902.
  32. Strain, M. C. and Richman, D. D. (2013). New assays for monitoring residual HIV burden in effectively treated individuals. Curr Opin HIV AIDS 8(2): 106-110.
  33. Yukl, S. A., Boritz, E., Busch, M., Bentsen, C., Chun, T. W., Douek, D., Eisele, E., Haase, A., Ho, Y. C., Hutter, G., Justement, J. S., Keating, S., Lee, T. H., Li, P., Murray, D., Palmer, S., Pilcher, C., Pillai, S., Price, R. W., Rothenberger, M., Schacker, T., Siliciano, J., Siliciano, R., Sinclair, E., Strain, M., Wong, J., Richman, D. and Deeks, S. G. (2013). Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog 9(5): e1003347.
  34. Gianella, S., Morris, S. R., Anderson, C., Spina, C. A., Vargas, M. V., Young, J. A., Richman, D. D., Little, S. J. and Smith, D. M. (2013). Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract. AIDS 27(1): 39-47.
  35. Beliakova-Bethell, N., Zhang, J. X., Singhania, A., Lee, V., Terry, V. H., Richman, D. D., Spina, C. A. and Woelk, C. H. (2013). Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells. AIDS 27(1): 29-37.
  36. Strain, M. C., Lada, S. M., Luong, T., Rought, S. E., Gianella, S., Terry, V. H., Spina, C. A., Woelk, C. H. and Richman, D. D. (2013). Highly precise measurement of HIV DNA by droplet digital PCR. PLoS One 8(4): e55943.
  37. Wagner, G. A., Pacold, M. E., Vigil, E., Caballero, G., Morris, S. R., Kosakovsky Pond, S. L., Little, S. J., Richman, D. D., Gianella, S. and Smith, D. M. (2013). Using ultradeep pyrosequencing to study HIV-1 coreceptor usage in primary and dual infection. J Infect Dis 208(2): 271-274.
  38. Le, T., Wright, E. J., Smith, D. M., He, W., Catano, G., Okulicz, J. F., Young, J. A., Clark, R. A., Richman, D. D., Little, S. J. and Ahuja, S. K. (2013). Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy. N Engl J Med 368(3): 218-230.
  39. Johnson, V. A., Calvez, V., Günthard, H. F., Paredes, R., Pillay, D., Shafer, R. W., Wensing, A. M. and Richman, D. D. (2013). Update of the drug resistance mutations in HIV-1: March 2013. Top Antivir Med 21(1): 6-14.
  40. Soto, P. C., Karris, M. Y., Spina, C. A., Richman, D. D. and Varki, A. (2013). Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. J Mol Med (Berl) 91(2): 261-270.
  41. Eriksson, S., Graf, E. H., Dahl, V., Strain, M. C., Yukl, S. A., Lysenko, E. S., Bosch, R. J., Lai, J., Chioma, S., Emad, F., Abdel-Mohsen, M., Hoh, R., Hecht, F., Hunt, P., Somsouk, M., Wong, J., Johnston, R., Siliciano, R. F., Richman, D. D., O'Doherty, U., Palmer, S., Deeks, S. G. and Siliciano, J. D. (2013). Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog 9(2): e1003174.
  42. Pérez-Santiago, J., Gianella, S., Massanella, M., Spina, C. A., Karris, M. Y., Var, S. R., Patel, D., Jordan, P. S., Young, J. A., Little, S. J., Richman, D. D. and Smith, D. M. (2013). Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS 27(12): 1921-1931.
  43. Katlama, C., Deeks, S. G., Autran, B., Martinez-Picado, J., van Lunzen, J., Rouzioux, C., Miller, M., Vella, S., Schmitz, J. E., Ahlers, J., Richman, D. D. and Sekaly, R. P. (2013). Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs. Lancet 381(9883): 2109-2117.
  44. Wie, S. H., Du, P., Luong, T. Q., Rought, S. E., Beliakova-Bethell, N., Lozach, J., Corbeil, J., Kornbluth, R. S., Richman, D. D. and Woelk, C. H. (2013). HIV downregulates interferon-stimulated genes in primary macrophages. J Interferon Cytokine Res 33(2): 90-95.
  45. Hatano, H., Strain, M. C., Scherzer, R., Bacchetti, P., Wentworth, D., Hoh, R., Martin, J. N., McCune, J. M., Neaton, J. D., Tracy, R. P., Hsue, P. Y., Richman, D. D. and Deeks, S. G. (2013). Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial. J Infect Dis 208(9): 1436-1442.
  46. Xu, Y., Duggineni, S., Espitia, S., Richman, D. D., An, J. and Huang, Z. (2013). A synthetic bivalent ligand of CXCR4 inhibits HIV infection. Biochem Biophys Res Commun 435(4): 646-650.
  47. Johnson, V. A., Calvez, V., Gunthard, H. F., Paredes, R., Pillay, D., Shafer, R. W., Wensing, A. M. and Richman, D. D. (2013). Update of the drug resistance mutations in HIV-1: March 2013. Top Antivir Med 21(1): 6-14.
  48. Gianella, S., Smith, D. M., Vargas, M. V., Little, S. J., Richman, D. D., Daar, E. S., Dube, M. P., Zhang, F., Ginocchio, C. C., Haubrich, R. H., Morris, S. R. and Team, C. (2013). Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men. Clin Infect Dis 57(3): 441-447.
  49. Massanella, M., Singhania, A., Beliakova-Bethell, N., Pier, R., Lada, S. M., White, C. H., Pérez-Santiago, J., Blanco, J., Richman, D. D., Little, S. J. and Woelk, C. H. (2013). Differential gene expression in HIV-infected individuals following ART. Antiviral Res 100(2): 420-428.
  50. Hightower, G. K., May, S. J., Pérez-Santiago, J., Pacold, M. E., Wagner, G. A., Little, S. J., Richman, D. D., Mehta, S. R., Smith, D. M. and Pond, S. L. (2013). HIV-1 clade B pol evolution following primary infection. PLoS One 8(6): e68188.
  51. Chaillon, A., Gianella, S., Vazquez, H., Ignacio, C., Zweig, A. C., Richman, D. D. and Smith, D. M. (2014). Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy. AIDS Res Hum Retroviruses 30(2): 165-169.
  52. Chaillon, A., Wagner, G. A., Hepler, N. L., Little, S. J., Kosakovsky Pond, S. L., Caballero, G., Pacold, M. E., Phung, P., Wrin, T., Richman, D. D., Wertheim, J. O. and Smith, D. M. (2013). Dynamics of viral evolution and neutralizing antibody response after HIV-1 superinfection. J Virol 87(23): 12737-12744.
  53. Coen, D., Richman, D. (2013). Antiviral Agents. In: Fields Virology, Lippincott, Williams & Wilkins (eds).
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