教育背景
PhD, National and Kapodistrian University of Athens, 2015
实验室信息
Eduardo Groisman lab
https://medicine.yale.edu/lab/groisman/
研究方向
Molecular Microbiology, Bacterial pathogens, Fungal transporters
发表论文
https://pubmed.ncbi.nlm.nih.gov/?term=krypotou+e1. Krypotou E, Kosti V, Amillis S, Myrianthopoulos V, Mikros E, Diallinas G. Modeling, substrate docking, and mutational analysis identify residues essential for the function and specificity of a eukaryotic purine-cytosine NCS1 transporter. J Biol Chem. 2012, 287: 36792-803.
2. Krypotou E, Diallinas G. Transport assays in filamentous fungi: kinetic characterization of the UapC purine transporter of Aspergillus nidulans. Fungal Genet Biol. 2014, 63: 1-8. doi: 10.1016/j.fgb.2013.12.004.
3. Krypotou E, Lambrinidis G, Evangelidis T, Mikros E, Diallinas G. Modelling, substrate docking and mutational analysis identify residues essential for function and specificity of the major fungal purine transporter AzgA. Mol Microbiol. 2014, 93: 129-45. doi: 10.1111/mmi.12646.
4. Krypotou E, Scazzocchio C, Diallinas G. Functional characterization of NAT/NCS2 proteins of Aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide. Fungal Genet Biol. 2015, 75: 56-63. doi: 10.1016/j.fgb.2015.01.009.
5. Krypotou E., Evangelidis T., Bobonis J., Pittis A.A., Gabaldón T., Scazzocchio C., Mikros E., Diallinas G. Origin, diversification and substrate specificity in the family of NCS1/FUR transporters. Mol Microbiol. 2015, 96: 927-50. doi: 10.1111/mmi.12982.
6. Lougiakis N, Gavriil ES, Kairis M, Sioupouli G, Lambrinidis G, Benaki D, Krypotou E, Mikros E, Marakos P, Pouli N, Diallinas G. Design and synthesis of purine analogues as highly specific ligands for FcyB, a ubiquitous fungal nucleobase transporter. Bioorg Med Chem. 2016, 24: 5941-52.
7. Listeria Placental Infection. Vázquez-Boland JA, Krypotou E, Scortti M.
MBio. 2017 Jun 27;8(3). pii: e00949-17. doi: 10.1128/mBio.00949-17.
8. Control of Bacterial Virulence through the Peptide Signature of the Habitat. Krypotou E, Scortti M, Grundström C, Oelker M, Luisi BF, Sauer-Eriksson AE, Vázquez-Boland J.Cell Rep. 2019 Feb 12;26(7):18151827.e5.ndoi:10.1016/j.celrep.2019.01.073.
9. Bacteria require phase separation for fitness in the mammalian gut. Krypotou E, Townsend GE, Gao X, Tachiyama S, Liu J, Pokorzynski ND, Goodman AL, Groisman EA. Science. 2023; 379(6637):1149-1156. doi: 10.1126/science.abn7229.
10. Advancing the fitness of gut commensal bacteria. Groisman EA, Han W, Krypotou E.
Science. 2023; 382(6672):766-768. doi: 10.1126/science.adh9165.