Adrian M. Piliponsky, Pediatrics, University of Washington, 2018-

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Adrian M. Piliponsky

Associate professor, Pediatrics, University of Washington, 2018-

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个人信息

教育背景

PhD, The Hebrew University of Jerusalem, Israel, 2003

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• Piliponsky, A. M., Shubin, N. J., Lahiri, A. K., Truong, P., Clauson, M., Niino, K., Tsuha, A. L., Nedospasov, S. A., Karasuyama, H., Reber, L. L., Tsai, M., Mukai, K. and Galli, S. J. (2019). Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice. Nat Immunol 20(2): 129-140.
• Altman, M. C., Lai, Y., Nolin, J. D., Long, S., Chen, C. C., Piliponsky, A. M., Altemeier, W. A., Larmore, M., Frevert, C. W., Mulligan, M. S., Ziegler, S. F., Debley, J. S., Peters, M. C. and Hallstrand, T. S. (2019). Airway epithelium-shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling. J Clin Invest.
• Piliponsky, A. M., Acharya, M. and Shubin, N. J. (2019). Mast Cells in Viral, Bacterial, and Fungal Infection Immunity. Int J Mol Sci 20(12).
• Shubin, N. J., Navalkar, K., Simpson, D., Yager, T. D., Cermelli, S., Seldon, T., Sullivan, E., Zimmerman, J. J., Permut, L. C. and Piliponsky, A. M. Serum identified with an aptamer-based multiplexed proteomic approach. Crit Care Med. (In press).
• Gendrin, C., Shubin, N. J., Boldenow, E., Merillat, S., Clauson, M., Power, D., Doran, K. S., Abrink, M., Pejler, G., Rajagopal, L. and Piliponsky, A. M. (2018). Mast cell chymase decreases the severity of group B Streptococcus infections. J Allergy Clin Immunol 142(1): 120-129 e126.
• Piliponsky, A. M. and Romani, L. (2018). The contribution of mast cells to bacterial and fungal infection immunity. Immunol Rev 282(1): 188-197.
• Shubin, N. J., Glukhova, V. A., Clauson, M., Truong, P., Abrink, M., Pejler, G., White, N. J., Deutsch, G. H., Reeves, S. R., Vaisar, T., James, R. G. and Piliponsky, A. M. (2017). Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation. J Allergy Clin Immunol 139(1): 323-334.
• Nolin, J. D., Lai, Y., Ogden, H. L., Manicone, A. M., Murphy, R. C., An, D., Frevert, C. W., Ghomashchi, F., Naika, G. S., Gelb, M. H., Gauvreau, G. M., Piliponsky, A. M., Altemeier, W. A. and Hallstrand, T. S. (2017). Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. JCI Insight 2(21).
• Piliponsky, A. M., Lahiri, A., Truong, P., Clauson, M., Shubin, N. J., Han, H. and Ziegler, S. F. (2016). Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis. Am J Respir Cell Mol Biol 55(2): 264-274.
• Gendrin, C., Vornhagen, J., Ngo, L., Whidbey, C., Boldenow, E., Santana-Ufret, V., Clauson, M., Burnside, K., Galloway, D. P., Adams Waldorf, K. M., Piliponsky, A. M. and Rajagopal, L. (2015). Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection. Sci Adv 1(6): e1400225.
• Lai, Y., Altemeier, W. A., Vandree, J., Piliponsky, A. M., Johnson, B., Appel, C. L., Frevert, C. W., Hyde, D. M., Ziegler, S. F., Smith, D. E., Henderson, Jr., WR, Gelb, M. H., Hallstrand, T. S. Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoeitin and IL-33. J Allergy Clin Immunol 2013; S0091-6749(13)01473-5.
• Schafer, B., Piliponsky, A. M., Oka, T., Song, C. H., Gerard, N. P., Gerard, C., Tsai, M., Kalesnikoff, J. and Galli, S. J. (2013). Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice. J Allergy Clin Immunol 131(2): 541-548 e541-549.
• Piliponsky, A. M., Chen, C. C., Rios, E. J., Treuting, P. M., Lahiri, A., Abrink, M., Pejler, G., Tsai, M. and Galli, S. J. (2012). The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol 181(3): 875-886.
• Akahoshi, M., Song, C. H., Piliponsky, A. M., Metz, M., Guzzetta, A., Abrink, M., Schlenner, S. M., Feyerabend, T. B., Rodewald, H. R., Pejler, G., Tsai, M. and Galli, S. J. (2011). Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest 121(10): 4180-4191.
• Lilla, J. N., Chen, C. C., Mukai, K., BenBarak, M. J., Franco, C. B., Kalesnikoff, J., Yu, M., Tsai, M., Piliponsky, A. M. and Galli, S. J. (2011). Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice. Blood 118(26): 6930-6938.
• Piliponsky, A. M., Chen, C. C., Grimbaldeston, M. A., Burns-Guydish, S. M., Hardy, J., Kalesnikoff, J., Contag, C. H., Tsai, M. and Galli, S. J. (2010). Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice. Am J Pathol 176(2): 926-938.
• Galli, S. J., Tsai, M. and Piliponsky, A. M. (2008). The development of allergic inflammation. Nature 454(7203): 445-454.
• Piliponsky, A. M., Chen, C. C., Nishimura, T., Metz, M., Rios, E. J., Dobner, P. R., Wada, E., Wada, K., Zacharias, S., Mohanasundaram, U. M., Faix, J. D., Abrink, M., Pejler, G., Pearl, R. G., Tsai, M. and Galli, S. J. (2008). Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nat Med 14(4): 392-398.
• Rios, E. J., Piliponsky, A. M., Ra, C., Kalesnikoff, J. and Galli, S. J. (2008). Rabaptin-5 regulates receptor expression and functional activation in mast cells. Blood 112(10): 4148-4157.
• Metz, M., Grimbaldeston, M. A., Nakae, S., Piliponsky, A. M., Tsai, M. and Galli, S. J. (2007). Mast cells in the promotion and limitation of chronic inflammation. Immunol Rev 217: 304-328.
• Nishimura, T., Myles, T., Piliponsky, A. M., Kao, P. N., Berry, G. J. and Leung, L. L. (2007). Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo. Blood 109(5): 1992-1997.
• Berent-Maoz, B., Piliponsky, A. M., Daigle, I., Simon, H. U. and Levi-Schaffer, F. (2006). Human mast cells undergo TRAIL-induced apoptosis. J Immunol 176(4): 2272-2278.
• Metz, M., Piliponsky, A. M., Chen, C. C., Lammel, V., Abrink, M., Pejler, G., Tsai, M. and Galli, S. J. (2006). Mast cells can enhance resistance to snake and honeybee venoms. Science 313(5786): 526-530.
• Puxeddu, I., Bader, R., Piliponsky, A. M., Reich, R., Levi-Schaffer, F. and Berkman, N. (2006). The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts. J Allergy Clin Immunol 117(1): 103-110.
• Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. and Tsai, M. (2005). Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu Rev Immunol 23: 749-786.
• Matsuda, K., Piliponsky, A. M., Iikura, M., Nakae, S., Wang, E. W., Dutta, S. M., Kawakami, T., Tsai, M. and Galli, S. J. (2005). Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response. J Allergy Clin Immunol 116(6): 1357-1363.
• Puxeddu, I., Alian, A., Piliponsky, A. M., Ribatti, D., Panet, A. and Levi-Schaffer, F. (2005). Human peripheral blood eosinophils induce angiogenesis. Int J Biochem Cell Biol 37(3): 628-636.
• Grimbaldeston, M. A., Chen, C. C., Piliponsky, A. M., Tsai, M., Tam, S. Y. and Galli, S. J. (2005). Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo. Am J Pathol 167(3): 835-848.
• Maurer, M., Wedemeyer, J., Metz, M., Piliponsky, A. M., Weller, K., Chatterjea, D., Clouthier, D. E., Yanagisawa, M. M., Tsai, M. and Galli, S. J. (2004). Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 432(7016): 512-516.
• Munitz, A., Piliponsky, A. M. and Levi-Schaffer, F. (2003). IgE-Independent Activation of Human Mast Cells Indicates their Role in the Late Phase Reaction of Allergic Inflammation. Cell Tissue Bank 4(1): 25-28.
• Puxeddu, I., Piliponsky, A. M., Bachelet, I. and Levi-Schaffer, F. (2003). Mast cells in allergy and beyond. Int J Biochem Cell Biol 35(12): 1601-1607.
• Maurer, M., Theoharides, T., Granstein, R. D., Bischoff, S. C., Bienenstock, J., Henz, B., Kovanen, P., Piliponsky, A. M., Kambe, N., Vliagoftis, H., Levi-Schaffer, F., Metz, M., Miyachi, Y., Befus, D., Forsythe, P., Kitamura, Y. and Galli, S. (2003). What is the physiological function of mast cells? Exp Dermatol 12(6): 886-910.
• Piliponsky, A. M., Gleich, G. J., Nagler, A., Bar, I. and Levi-Schaffer, F. (2003). Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor. Blood 101(5): 1898-1904.
• Levi-Schaffer, F. and Piliponsky, A. M. (2003). Tryptase, a novel link between allergic inflammation and fibrosis. Trends Immunol 24(4): 158-161.
• Levi-Schaffer, F., Micera, A., Mechoulam, H., Puxeddu, I., Piliponsky, A. M., Zamir, E. and Aloe, L., Pe’er J. Nerve Growth Factor and eosinophils in inflammed juvenile conjunctival nevus. Invest Opththalmol Vis Sci 2002; 43: 1850-1856.
• Piliponsky, A. M., Gleich, G. J., Bar, I. and Levi-Schaffer, F. (2002). Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation. Mol Immunol 38(16-18): 1369.
• Smith, S. J., Piliponsky, A. M., Hartman, M. and Levi-Schaffer, F. Stem cell factor: a paradigm between mast cells, eosinophils and fibroblasts. All Clin Immunol Int 2002; 14: 52-59
• Smith, S. J., Piliponsky, A. M., Rosenhead, F., Elchalal, U., Nagler, A. and Levi-Schaffer, F. (2002). Dexamethasone inhibits maturation, cytokine production and Fc epsilon RI expression of human cord blood-derived mast cells. Clin Exp Allergy 32(6): 906-913.
• Piliponsky, A. M., Pickholtz, D., Gleich, G. J. and Levi-Schaffer, F. (2001). Human eosinophils induce histamine release from antigen-activated rat peritoneal mast cells: a possible role for mast cells in late-phase allergic reactions. J Allergy Clin Immunol 107(6): 993-1000.
• Hartman, M., Piliponsky, A. M., Temkin, V. and Levi-Schaffer, F. (2001). Human peripheral blood eosinophils express stem cell factor. Blood 97(4): 1086-1091.
• Spoelstra, F. M., Postma, D. S. and Kauffman, H. F. (2001). Mutual activation of pulmonary fibroblasts and eosinophils, and modulation by drugs in relation to asthma. Clin Exp Allergy 31(6): 808-816.
• Touitou, E., Godin, B., Dayan, N., Weiss, C., Piliponsky, A. and Levi-Schaffer, F. (2001). Intracellular delivery mediated by an ethosomal carrier. Biomaterials 22(22): 3053-3059.
• Piliponsky, A. M. and Levi-Schaffer, F. (2000). Regulation of apoptosis in mast cells. Apoptosis 5(5): 435-441.
• Piliponsky, A. M., Pickholtz, D., Gleich, G. J. and Levi-Schaffer, F. (1999). Eosinophils activate mast cells to release histamine. Int Arch Allergy Immunol 118(2-4): 202-203.