David Brigstock lab focuses on the extracellular vesicles-based interplays between parenchymal and non-parenchymal cells in the liver, and potential therapeutic against liver diseases including fibrosis, alcoholic liver disease, and non-alcoholic steatohepatitis.
non-alcoholic steatohepatitis pathogenesis mechanisms; extracellular vesicle-based potential therapeutic for liver diseases; hepatitis virology.
1. Li, Xinlei, Zhaohui Xu, Bidisha Mitra, Minhang Wang, Haitao Guo, Zongdi Feng Elevated NTCP expression by an iPSC-derived human hepatocyte maintenance medium enhances HBV infection in NTCP-reconstituted HepG2 cells. Cell & Bioscience. 2021. 11(1):123. (doi: 10.1186/s13578-021-00641-1)
2. Li, Xinlei*, Ruju Chen, Sherri Kemper, and David R. Brigstock. Structural and functional characterization of fibronectin in extracellular vesicles from hepatocytes. Frontiers in Cell and Developmental Biology. 2021. 18(9):640667. (doi: 10.3389/fcell.2021.640667) (*Corresponding author)
3. Li, Xinlei and Tao Peng. Strategy, Progress, and Challenges of Drug Repurposing for Efficient Antiviral Discovery. Frontiers in Pharmacology. 2021. 4(12):660710. (doi: 10.3389/fphar.2021.660710)
4. Li, Xinlei, Ruju Chen, Sherri Kemper, and David R. Brigstock. Dynamic changes in function and proteomic composition of extracellular vesicles from hepatic stellate cells during cellular activation. Cells, 2020. 9(2):290. (doi: 10.3390/cells9020290)
5. Li, Xinlei#, Ruju Chen#, Sherri Kemper, and David R. Brigstock. Extracellular Vesicles from Hepatocytes Are Therapeutic for Toxin-Mediated Fibrosis and Gene Expression in the Liver. Frontiers in Cell and Developmental Biology, 2020. 7:368. (doi: 10.3389/fcell.2019.00368) (#co-first author)
6. Li, Xinlei, Jinqian Li, Yetong Feng, Hua Cai, Yi-Ping Li, Tao Peng. Long-chain fatty acyl-coenzyme A suppresses hepatitis C virus infection by targeting virion-bound lipoproteins. Antiviral Research, 2020. 177: 104734. (doi: 10.1016/j.antiviral.2020.104734)
7. Liu, Chang, Wei Cai, Xin Yin, Zimin Tang, Guiping Wen, Charuta Ambardekar, Xinlei Li, Dong Ying, Zongdi Feng, Zizheng Zheng, and Ningshao Xia. An Optimized High-Throughput Neutralization Assay for Hepatitis E Virus (HEV) Involving Detection of Secreted Porf2. Viruses, 2019. 11(1):64. (doi: 10.3390/v11010064)
8. Yin, Xin, Xinlei Li, Charuta Ambardekar, Zhimin Hu, Sebastien Lhomme, and Zongdi Feng. Hepatitis E virus persists in the presence of a type III interferon response. PLoS pathogens, 2017. 13(5): e1006417. (doi: 10.1371/journal.ppat.1006417)
9. Yin, Xin, Xinlei Li, and Zongdi Feng. Role of Envelopment in the HEV Life Cycle. Viruses, 2016. 8(8):229. (doi: 10.3390/v8080229)
10. Cai, Hua, Wenxia Yao, Leike Li, Xinlei Li, Longbo Hu, Ruiming Mai, and Tao Peng. Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A. Scientific reports, 2016. 6: 27778. (doi: 10.1038/srep27778)
11. Li, Xinlei, Rong Zhou, Tao Peng (2015). The current progress in the development of hepatitis C virus cell culture systems. Chin J Viral Dis. 5(1):58-66.
李新磊，周荣，彭涛（2015）.丙型肝炎病毒体外细胞培养系统研究进展。中国病毒病杂志，5（1）：58-66
12. Yao, Wenxia#, Hua Cai#, Xinlei Li, Ting Li, Longbo Hu and Tao Peng (2014). Endoplasmic reticulum stress links hepatitis C virus RNA replication to WT-PGC-1α/L-PGC-1α upregulation. J. Virol. 88(15):8361-74. (doi: 10.1128/JVI.01202-14) (#co-first author)
13. Li, Xinlei#, Hanfang Jiang#, Linbing Qu, Wenxia Yao, Hua Cai, Ling Chen and Tao Peng (2014). Hepatocyte Nuclear Factor 4α and Downstream Secreted Phospholipase A2 GXIIB Regulate Production of Infectious Hepatitis C Virus. J Virol 88(1): 612-627. (doi: 10.1128/JVI.02068-13) (#co-first author)
14. Li, Xinlei, Wenxia Yao, Tao Peng. Chapter 27 Polyomaviridae. In: Douglas D. Richman, Richard J. Whitley, and Frederick G. Hayden Editor. Clinical Virology (3rd Edition) (Chinese Edition). Beijing, Science Press; 2012. ISBN-10: 9787030339430.
李新磊，姚文霞，彭涛 译. 第27章 多瘤病毒. D.D.里奇曼 等 编 临床病毒学. 陈敬贤，周荣，彭涛 等 主译。北京；科学出版社，2012.