教育背景
Doctor
实验室信息
Ralph Nixon Lab at Center for Dementia Research, NKI, New York
https://www.cdr.rfmh.org/research/nixon-lab/
研究方向
Endo-lysosomal pathway, Alzheimer's disease, Frontotemporal Dementia, Intracellular pathogens, endocytic trafficking, NGF-cholinergic signaling, Signaling endosome, Macrophages, Autophagy, Lysosomal degradation, Endocytosis
发表论文
https://scholar.google.com/citations?user=3DEjmSoAAAAJ&hl=en1. Ying Jiang, Kuldeep Sachdeva, Chris N. Goulbourne, Martin J. Berg, James Peddy, Philip H. Stavrides, AnnaPensalfini, Monika Pawlik, Lauren Whyte, Basavaraj S. Balapal, Subbanna Shivakumar, Cynthia Bleiwas, John F.Smiley, Paul M. Mathews, Ralph A. Nixon. Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration. bioRxiv 2024.09.19.613736; doi: https://doi.org/10.1101/2024.09.19.613736 (in Revision).
2. Kuldeep Sachdeva, Manisha Goel, Malvika Sudhaka, Mansi Mehta, Rajmani Raju, Karthik Raman, Amit Singh, Varadharajan Sundaramurthy. Mycobacterium tuberculosis (Mtb) lipid-mediated lysosomal rewiring in infected macrophages modulates intracellular Mtb trafficking and survival. JBC 2020. doi:10.1074/jbc.RA120.012809
3. Kuldeep Sachdeva, Manisha Goel, Varadharajan Sundaramurthy. Heterogeneity in the endocytic capacity of an individual macrophage in a population determines its infectivity and subcellular trafficking of phagocytosed Mtb. Traffic 2020. https://doi.org/10.1111/tra.12752
4. Kuldeep Sachdeva, Varadharajan Sundaramurthy. The interplay of host lysosomes and intracellular pathogens. Front. Cell. Infect. Microbiol. 2020. doi:10.3389/fcimb.2020.595502
5. Manisha Goel, Kuldeep Sachdeva, Shah-e-Jahan, Sandeep Chandrashekharappa, Parveen Vemula, Varadharajan Sundaramurthy. Chemical modulators causing hyper virulent Mtb phenotype identify novel mechanisms for control of intracellular Mtb survival. (Manuscript in preparation).