Education

M.D. in Biochemistry, University of California, San Francisco, 1995
Ph.D. in Medicine, University of California, San Francisco, 1993

Current position

Associate Physician, Massachusetts General Hospital
Affiliate of Harvard Stem Cell Institute
Associate Professor Medicine (Microbiology and Immunobiology), Massachusetts General Hospital, Harvard Medical School, Boston, MA
Member of Immunology Program, Harvard Medical School, Boston, MA

Publications (selecte)

1. Du, J., Reeves, A. Z., Klein, J. A., Twedt, D. J., Knodler, L. A. and Lesser, C. F. (2016). The type III secretion system apparatus determines the intracellular niche of bacterial pathogens. Proc Natl Acad Sci U S A 113(17): 4794-4799.

2. Reeves, A. Z., Spears, W. E., Du, J., Tan, K. Y., Wagers, A. J. and Lesser, C. F. (2015). Engineering Escherichia coli into a protein delivery system for mammalian cells. ACS Synth Biol 4(5): 644-654.

3. Costa, S. C. and Lesser, C. F. (2014). A multifunctional region of the Shigella type 3 effector IpgB1 is important for secretion from bacteria and membrane targeting in eukaryotic cells. PLoS One 9(4): e93461.

4. Costa, S. C., Schmitz, A. M., Jahufar, F. F., Boyd, J. D., Cho, M. Y., Glicksman, M. A. and Lesser, C. F. (2012). A new means to identify type 3 secreted effectors: functionally interchangeable class IB chaperones recognize a conserved sequence. MBio 3(1).

5. Sukumaran, B., Mastronunzio, J. E., Narasimhan, S., Fankhauser, S., Uchil, P. D., Levy, R., Graham, M., Colpitts, T. M., Lesser, C. F. and Fikrig, E. (2011). Anaplasma phagocytophilum AptA modulates Erk1/2 signalling. Cell Microbiol 13(1): 47-61.

6. Durand-Heredia, J. M., Yu, H. H., De Carlo, S., Lesser, C. F. and Janakiraman, A. (2011). Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli. J Bacteriol 193(6): 1405-1413.

7. de Groot, J. C., Schluter, K., Carius, Y., Quedenau, C., Vingadassalom, D., Faix, J., Weiss, S. M., Reichelt, J., Standfuss-Gabisch, C., Lesser, C. F., Leong, J. M., Heinz, D. W., Bussow, K. and Stradal, T. E. (2011). Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli. Structure 19(9): 1294-1306.

8. Sukumaran, B., Mastronunzio, J. E., Narasimhan, S., Fankhauser, S., Uchil, P. D., Levy, R., Graham, M., Colpitts, T. M., Lesser, C. F. and Fikrig, E. (2011). Anaplasma phagocytophilum AptA modulates Erk1/2 signalling. Cell Microbiol 13(1): 47-61.

9. Schmitz, A. M., Morrison, M. F., Agunwamba, A. O., Nibert, M. L. and Lesser, C. F. (2009). Protein interaction platforms: visualization of interacting proteins in yeast. Nat Methods 6(7): 500-502.

10. Slagowski, N. L., Kramer, R. W., Morrison, M. F., LaBaer, J. and Lesser, C. F. (2008). A functional genomic yeast screen to identify pathogenic bacterial proteins. PLoS Pathog 4(1): e9.

11. Siggers, K. A. and Lesser, C. F. (2008). The Yeast Saccharomyces cerevisiae: a versatile model system for the identification and characterization of bacterial virulence proteins. Cell Host Microbe 4(1): 8-15.

12. Huang, J., Lesser, C. F. and Lory, S. (2008). The essential role of the CopN protein in Chlamydia pneumoniae intracellular growth. Nature 456(7218): 112-115.

13. Kramer, R. W., Slagowski, N. L., Eze, N. A., Giddings, K. S., Morrison, M. F., Siggers, K. A., Starnbach, M. N. and Lesser, C. F. (2007). Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation. PLoS Pathog 3(2): e21.

14. Lesser, C. F. and Miller, S. I. (2001). Expression of microbial virulence proteins in Saccharomyces cerevisiae models mammalian infection. EMBO J 20(8): 1840-1849.