VM
Varpu Marjomaki
  • University Lecturer, Department of Biological and Environmental Science, University of Jyväskylä
研究方向
  • Microbiology
个人信息

教育背景

Ph.D. in Molecular Biology, University of Jyväskylä, Finland, 1994

研究方向

membrane traffikcing, anti-viral development, virus infection

发表论文

Since 2004
• Huttunen, M., Waris, M., Kajander, R., Hyypiä, T. and Marjomäki, V. (2014). Coxsackievirus A9 Infects Cells via Non-acidic Multivesicular Bodies. J Virol. (Epub ahead of print).
• Bhowmik, S., Ghosh, B. N., Marjomäki, V. and Rissanen, K. (2014). Nanomolar Pyrophosphate Detection in Water and in a Self-Assembled Hydrogel of a Simple Terpyridine-Zn Complex. J Am Chem Soc. (Epub ahead of print)
• Koho, T., Koivunen, M. R., Oikarinen, S., Kummola, L., Mäkinen, S., Mähönen, A. J., Sioofy-Khojine, A., Marjomäki, V., Kazmertsuk, A., Junttila, I., Kulomaa, M. S., Hyöty, H., Hytönen, V. P. and Laitinen, O. H. (2014). Coxsackievirus B3 VLPs purified by ion exchange chromatography elicit strong immune responses in mice. Antiviral Res 104: 93-101.
• Marjomäki, V., Lahtinen, T., Martikainen, M., Koivisto, J., Malola, S., Salorinne, K., Pettersson, M. and Häkkinen, H. (2014). Site-specific targeting of enterovirus capsid by functionalized monodisperse gold nanoclusters. Proc Natl Acad Sci U S A 111(4): 1277-1281.
• Kaakinen, M., Huttunen, S., Paavolainen, L., Marjomäki, V., Heikkilä, J. and Eklund, L. (2014). Automatic detection and analysis of cell motility in phase-contrast time-lapse images using a combination of maximally stable extremal regions and Kalman filter approaches. J Microsc 253(1): 65-78.
• Nieminen, T., Toivanen, P. I., Rintanen, N., Heikura, T., Jauhiainen, S., Airenne, K. J., Alitalo, K., Marjomäki, V. and Ylä-Herttuala, S. (2014). The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features. Biochim Biophys Acta 1840(1): 454-463.
• Turkki, P., Makkonen, K. E., Huttunen, M., Laakkonen, J. P., Ylä-Herttuala, S., Airenne, K. J. and Marjomäki, V. (2013). Cell susceptibility to baculovirus transduction and echovirus infection is modified by protein kinase C phosphorylation and vimentin organization. J Virol 87(17): 9822-9835.
• Makkonen, K. E., Turkki, P., Laakkonen, J. P., Ylä-Herttuala, S., Marjomäki, V. and Airenne, K. J. (2013). 6-o- and N-sulfated syndecan-1 promotes baculovirus binding and entry into Mammalian cells. J Virol 87(20): 11148-11159.
• Krieger, S. E., Kim, C., Zhang, L., Marjomäki, V. and Bergelson, J. M. (2013). Echovirus 1 entry into polarized Caco-2 cells depends on dynamin, cholesterol, and cellular factors associated with macropinocytosis. J Virol 87(16): 8884-8895.
• Norarat, R., Marjomäki, V., Chen, X., Zhaohong, M., Minqin, R., Chen, C.-B., Bettiol, A., Whitlow, H. J. and Watt, F. (2013). Ion-induced fluorescence imaging of endosomes. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 306: 113-116.
• Siljamäki, E., Rintanen, N., Kirsi, M., Upla, P., Wang, W., Karjalainen, M., Ikonen, E. and Marjomäki, V. (2013). Cholesterol dependence of collagen and echovirus 1 trafficking along the novel alpha2beta1 integrin internalization pathway. PLoS One 8(2): e55465.
• Wu, X., Pertovaara, H., Dastidar, P., Vornanen, M., Paavolainen, L., Marjomäki, V., Järvenpää, R., Eskola, H. and Kellokumpu-Lehtinen, P. L. (2013). ADC measurements in diffuse large B-cell lymphoma and follicular lymphoma: a DWI and cellularity study. Eur J Radiol 82(4): e158-164.
• Kankaanpää, P., Paavolainen, L., Tiitta, S., Karjalainen, M., Päivärinne, J., Nieminen, J., Marjomäki, V., Heino, J. and White, D. J. (2012). BioImageXD: an open, general-purpose and high-throughput image-processing platform. Nat Methods 9(7): 683-689.
• Snijder, B., Sacher, R., Rämö, P., Liberali, P., Mench, K., Wolfrum, N., Burleigh, L., Scott, C. C., Verheije, M. H., Mercer, J., Moese, S., Heger, T., Theusner, K., Jurgeit, A., Lamparter, D., Balistreri, G., Schelhaas, M., De Haan, C. A., Marjomäki, V., Hyypiä, T., Rottier, P. J., Sodeik, B., Marsh, M., Gruenberg, J., Amara, A., Greber, U., Helenius, A. and Pelkmans, L. (2012). Single-cell analysis of population context advances RNAi screening at multiple levels. Mol Syst Biol 8: 579.
• Wirth, T., Pikkarainen, J. T., Samaranayake, H. D., Lehtolainen-Dalkilic, P., Lesch, H. P., Airenne, K. J., Marjomäki, V. and Ylä-Herttuala, S. P. (2012). Efficient gene therapy based targeting system for the treatment of inoperable tumors. J Gene Med 14(4): 221-230.
• Paavolainen, L., Kankaanpää, P., Ruusuvuori, P., McNerney, G., Karjalainen, M. and Marjomäki, V. (2012). Application independent greedy particle tracking method for 3D fluorescence image series. ISBI 672-675.
• Munukka, E., Wiklund, P., Pekkala, S., Völgyi, E., Xu, L., Cheng, S., Lyytikäinen, A., Marjomäki, V., Alen, M., Vaahtovuo, J. and Keinänen-Kiukaanniemi, S. (2012). Women with and without metabolic disorder differ in their gut microbiota composition. Obesity (Silver Spring) 20(5): 1082-1087.
• Rintanen, N., Karjalainen, M., Alanko, J., Paavolainen, L., Maki, A., Nissinen, L., Lehkonen, M., Kallio, K., Cheng, R. H., Upla, P., Ivaska, J. and Marjomäki, V. (2012). Calpains promote alpha2beta1 integrin turnover in nonrecycling integrin pathway. Mol Biol Cell 23(3): 448-463.
• Karjalainen, M., Rintanen, N., Lehkonen, M., Kallio, K., Mäki, A., Hellstrom, K., Siljamaki, V., Upla, P. and Marjomäki, V. (2011). Echovirus 1 infection depends on biogenesis of novel multivesicular bodies. Cell Microbiol 13(12): 1975-1995.
• Mai, A., Veltel, S., Pellinen, T., Padzik, A., Coffey, E., Märjomaki, V. and Ivaska, J. (2011). Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration. J Cell Biol 194(2): 291-306.
• Korpisalo, P., Hytonen, J. P., Laitinen, J. T., Laidinen, S., Parviainen, H., Karvinen, H., Siponen, J., Marjomäki, V., Vajanto, I., Rissanen, T. T. and Ylä-Herttuala, S. (2011). Capillary enlargement, not sprouting angiogenesis, determines beneficial therapeutic effects and side effects of angiogenic gene therapy. Eur Heart J 32(13): 1664-1672.
• Heikkilä, O., Susi, P., Tevaluoto, T., Härmä, H., Marjomäki, V., Hyypiä, T. and Kiljunen, S. (2010). Internalization of coxsackievirus A9 is mediated by {beta}2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin. J Virol 84(7): 3666-3681.
• Jokinen, J., White, D. J., Salmela, M., Huhtala, M., Käpylä, J., Sipilä, K., Puranen, J. S., Nissinen, L., Kankaanpää, P., Marjomäki, V., Hyypiä, T., Johnson, M. S. and Heino, J. (2010). Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1. EMBO J 29(1): 196-208.
• Laakkonen, J. P., Mäkelä, A. R., Kakkonen, E., Turkki, P., Kukkonen, S., Peranen, J., Ylä-Herttuala, S., Airenne, K. J., Oker-Blom, C., Vihinen-Ranta, M. and Marjomäki, V. (2009). Clathrin-independent entry of baculovirus triggers uptake of E. coli in non-phagocytic human cells. PLoS One 4(4): e5093.
• Upla, P., Hyypiä, T. and Marjomäki V (2009). Role of rafts in virus infection. Future virology 4(5) 487-500.
• Sangyuenyongpipat, S., Marjomäki, V., Ikonen, S., Sajavaara, T., Sagari A. R., A., Gorelick, S., Laitinen, M. and Whitlow, H. J. (2009). Development of micro-contact printing oc osteosarcoma cells using MeV ion beam lithography. Nucl. Instr. Meth.
• Korpisalo, P., Karvinen, H., Rissanen, T. T., Kilpijoki, J., Märjomaki, V., Baluk, P., McDonald, D. M., Cao, Y., Eriksson, U., Alitalo, K. and Ylä-Herttuala, S. (2008). Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels. Circ Res 103(10): 1092-1099.
• Karjalainen, M., Kakkonen, E., Upla, P., Paloranta, H., Kankaanpää, P., Liberali, P., Renkema, G. H., Hyypiä, T., Heino, J. and Märjomaki, V. (2008). A Raft-derived, Pak1-regulated entry participates in alpha2beta1 integrin-dependent sorting to caveosomes. Mol Biol Cell 19(7): 2857-2869.
• Liberali, P., Kakkonen, E., Turacchio, G., Valente, C., Spaar, A., Perinetti, G., Böckmann, R. A., Corda, D., Colanzi, A., Marjomaki, V. and Luini, A. (2008). The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS. EMBO J 27(7): 970-981.
• Upla, P., Marjomäki, V., Nissinen, L., Nylund, C., Waris, M., Hyypiä, T. and Heino, J. (2008). Calpain 1 and 2 are required for RNA replication of echovirus 1. J Virol 82(3): 1581-1590.
• Toriseva, M. J., Ala-aho, R., Karvinen, J., Baker, A. H., Märjomaki, V. S., Heino, J. and Kähäri, V. M. (2007). Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts. J Invest Dermatol 127(1): 49-59.
• Matilainen, H., Rinne, J., Gilbert, L., Marjomäki, V., Reunanen, H. and Oker-Blom, C. (2005). Baculovirus entry into human hepatoma cells. J Virol 79(24): 15452-15459.
• Pietiäinen, V. M., Marjomäki, V., Heino, J. and Hyypiä, T. (2005). Viral entry, lipid rafts and caveosomes. Ann Med 37(6): 394-403.
• Marjomäki, V. and Schaible, U. E. (2005). Microbial strategies to exploit host cells. Meeting on spatial and temporal dynamics of the endomembrane system. EMBO Rep 6(5): 408-412.
• Käpylä, J., Jäälinoja, J., Tulla, M., Ylöstalo, J., Nissinen, L., Viitasalo, T., Vehviläinen, P., Marjomäki, V., Nykvist, P., Säämanen, A. M., Farndale, R. W., Birk, D. E., Ala-Kokko, L. and Heino, J. (2004). The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix. J Biol Chem 279(49): 51677-51687.
• Pietiäinen, V., Marjomäki, V., Upla, P., Pelkmans, L., Helenius, A. and Hyypiä, T. (2004). Echovirus 1 endocytosis into caveosomes requires lipid rafts, dynamin II, and signaling events. Mol Biol Cell 15(11): 4911-4925.
• Ojala, K., Tikka, P. J., Kautto, L., Käpylä, P., Marjomäki, V. and Oker-Blom, C. (2004). Expression and trafficking of fluorescent viral membrane proteins in baculovirus-transduced BHK cells. J Biotechnol 114(1-2): 165-175.
• Xing, L., Huhtala, M., Pietiäinen, V., Käpylä, J., Vuorinen, K., Marjomäki, V., Heino, J., Johnson, M. S., Hyypiä, T. and Cheng, R. H. (2004). Structural and functional analysis of integrin alpha2I domain interaction with echovirus 1. J Biol Chem 279(12): 11632-11638.
• Räty, J. K., Airenne, K. J., Marttila, A. T., Marjomäki, V., Hytonen, V. P., Lehtolainen, P., Laitinen, O. H., Mähönen, A. J., Kulomaa, M. S. and Yla-Herttuala, S. (2004). Enhanced gene delivery by avidin-displaying baculovirus. Mol Ther 9(2): 282-291.
• Upla, P., Marjomäki, V., Kankaanpää, P., Ivaska, J., Hyypiä, T., Van Der Goot, F. G. and Heino, J. (2004). Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization. Mol Biol Cell 15(2): 625-636.
• Toivola, J., Michel, P. O., Gilbert, L., Lahtinen, T., Marjomäki, V., Hedman, K., Vuento, M. and Oker-Blom, C. (2004). Monitoring human parvovirus B19 virus-like particles and antibody complexes in solution by fluorescence correlation spectroscopy. Biol Chem 385(1): 87-93.