Kang Liu
  • Faculty, Department of Microbiology and Immunology, Columbia University Medical Center, USA, USA,
研究方向
  • Immunology
个人信息

教育背景

Ph.D., The Rockefeller University, 2004

研究方向

Dendritic cell, hematopoiesis, single cell culture

发表论文

1. Lee J, Zhou YJ, Ma W, Zhang W, Aljoufi A, Luh T, Lucero K, Liang D, Thomsen M, Bhagat G, Shen Y, Liu K. Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors. Nature Immunology, 18(8):877-888. 2017

2. Collins A, Rothman N, Liu K, Reiner S. Eomesodermin and T-bet mark developmentally distinct human natural killer cells. JCI Insight. 2(5): e90063. Doi:10.1172. 2017

3. Lee J, Breton G, Aljoufi A, Zhou YJ, Puhr S, Nussenzweig MC, Liu K. Clonal analysis of human dendritic cell progenitor using a stromal cell culture. Journal of Immunological Methods. 425:21-6. 2015

4. Breton G, Lee J, Liu K, Nussenzweig MC. Defining human dendritic cell progenitors by multiparametric flow cytometry. Nature Protocol 10(9):1407-22. 2015

5. Breton G, Lee L, Zhou YJ, Schreiber JJ, Keler T, Puhr S, Anandasabapathy N, Sarah Schlesinger S, Caskey M, Liu K and Nussenzweig MC Circulating Precursors of Human CD1c+ and CD141+ Dendritic Cells. Journal of Experimental Medicine 212(3):401-13. 2015

6. Lee J, Breton G, Oliveira TY, Zhou YJ, Aljoufi A, Puhr S, Cameron MJ, Rafick-Pierre Sékaly RP, Nussenzweig MC and Liu K, Restricted Dendritic Cell and Monocyte Progenitors in Human Cord Blood and Bone Marrow. Journal of Experimental Medicine 212(3):385-99. 2015

7. Franklin RA, Liao W, Sarkar A, Kim MV, Bivona MR, Liu K, Pamer EG, Li MO. The cellular and molecular origin of tumor-associated macrophages. Science 344(6186):921-5. 2014

8. Ghosh HS, Ceribelli M, Matos I, Lazarovici A, Bussemaker HJ, Lasorella A, Hiebert SW, Liu K, Staudt LM, Reizis B. ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2. Journal of Experimental Medicine 211(8):1623-35. 2014

9. Subramanian M, Hayes CD, Thome JJ, Thorp E, Matsushima GK, Herz J, Farber DL, Liu K, Lakshmana M, Tabas I. An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. Journal of Clinical Investigation. 124(3):1296-308. 2014

10. Meredith MM, Liu K, Kamphorst AO, Idoyaga J, Yamane A, Guermonprez P, Rihn S, Yao KH, Silva IT, Oliveira TY, Skokos D, Casellas R, Nussenzweig MC. Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state. Journal of Experimental Medicine 209(9):1583-93. 2012

11. Meredith MM, Liu K, Darrasse-Jeze G, Kamphorst AO, Schreiber HA, Guermonprez P, Idoyaga J, Cheong C, Yao KH, Niec RE, Nussenzweig MC. Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. Journal of Experimental Medicine 209(6):1153-65. 2012

12. Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, Ng D, Klinakis A, Charo IF, Jung S, Gommerman JL, Ivanov II, Liu K, Merad M, Reizis B. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity 35(5):780-91. 2011

13. Anandasabapathy N, Victora GD, Meredith M, Feder R, Dong B, Kluger C, Yao K, Dustin ML, Nussenzweig MC, Steinman RM, Liu K*. Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. Journal of Experimental Medicine 208(8):1695-705. 2011

14. Ginhoux F, Liu K, Helft J, Bogunovic M, Greter M, Hashimoto D, Price J, Yin N, Bromberg J, Lira SA, Stanley ER, Nussenzweig M, Merad M. The origin and development of nonlymphoid tissue CD103+ DCs. Journal of Experimental Medicine 206(13):3115-30. 2009

15. Bogunovic M, Ginhoux F, Helft J, Shang L, Hashimoto D, Greter M, Liu K, Jakubzick C, Ingersoll MA, Leboeuf M, Stanley ER, Nussenzweig M, Lira SA, Randolph GJ, Merad M. Origin of the lamina propria dendritic cell network. Immunity 31(3):513-25. 2009

16. Darrasse-Jèze G, Deroubaix S, Mouquet H, Victoria G, Eisenreich T, Yao K, Rudensky A, Liu K and Nussenzweig MC. Feedback of regulatory T cell homeostasis by dendritic cells in-vivo. Journal of Experimental Medicine 206(9):1853-62. 2009

17. Liu K, Victora GD, Schwickert TA, Guermonprez P, Meredith MM, Yao K, Chu FF, Randolph, GJ, Rudensky AY, Nussenzweig M*. In vivo analysis of dendritic cell development and homeostasis. Science 324(5925):392-7. 2009

18. Waskow C, Liu K, Darrasse-Jeze G, Ginhoux F, Merad M, Shengelia T, Yao K, Nussenzweig M. Flk2 is required for dendritic cell development in peripheral lymphoid tissues. Nature Immunology 9(6):676-83. 2008

19. Bulloch K, Miller MM, Gal-Toth J, Milner TA, Gottfried AB, Waters EM, Kaunzner UW, Liu K, Lindquist R, Nussenzweig M.C, Steinman RM, McEwen B.S. CD11c/EYFP transgene illuminates a discrete network of dendritic cells within neonatal, adult and injured mouse brain. J. Comp. Neurol. 508(5):687-710, 2008

20. Liu K, Waskow C, Liu X, Yao K, Hoh J, Nussenzweig M. Origin of dendritic cells in peripheral lymphoid organs of mice. Nature Immunology 8(6):578-83, 2007

21. Dudziak D, Kamphorst A.O, Heidkamp G.F, Buchholz V.R, Trumpfheller C, Yamazaki S, Cheong C, Liu K, Lee H.W, Park C.G, Steinman R.M, Nussenzweig M.C. Differential antigen processing by dendritic cell subsets in vivo. Science 315(5808):107-11, 2007

22. Liu K, Idoyaga J, Charalambous A, Fujii, S, Bonito, A.J, Mordoh J, Wainstok, R, Bai XF, Liu Y, Steinman R.M. Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells. Journal of Experimental Medicine 202(11): 1507-16, 2005

23. Fujii S, Liu K, Smith C, Bonito A.J, Steinman R.M. The initiation of T cell immunity via maturing dendritic cells in vivo reflects distinct contributions of inflammatory cytokines and CD40 ligation. Journal of Experimental Medicine 199(12):1607-18. 2004

24. Liu K, Iyoda T, Saternus M, Kimura Y, Inaba, K, and Steinman, R.M. Immune tolerance after delivery of dying cells to dendritic cells in situ. Journal of Experimental Medicine 196: 1091-1097, 2002

25. Iyoda T, Shimoyama S, Liu K, Omatsu, Y, Akiyama Y, Maeda Y, Takahara K, Steinman R.M, and Inaba K. The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. Journal of Experimental Medicine 195: 1289-1302, 2002.

26. Tamura Y, Peng P, Liu K, Daou M. and Srivastava P.K. Immunotherapy of tumors with autologous tumor-derived heat shock proteins preparations. Science 278:117-120, 1997