Education

PhD, University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA, 2009

Current position

Senior Scientist and Wellcome Trust-DBT India Alliance Intermediate Fellow, Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Chandigarh, India

Publications

1. Google scholar link: https://scholar.google.co.in/citations?user=VE8sN1sAAAAJ&hl=en

2. ORCID ID: https://orcid.org/0000-0001-5476-4127

3. Amit Tuli* and Mahak Sharma*. How to do business with lysosomes: Salmonella leads the way. Current Opinion in Microbiology, 47: 1-7 (2018). *co-corresponding author [invited review].

4. Subhash B. Arya, Gaurav Kumar, Harmeet Kaur, Amandeep Kaur, and Amit Tuli*. Arl11 regulates lipopolysaccharide-stimulated macrophage activation by promoting mitogen-activated protein kinase (MAPK) signaling. Journal of Biological Chemistry, 293(25): 9892-9909 (2018). *corresponding author.

5. Xavier Michelet#,*, Amit Tuli#,*, Huixian Gan, Carolina Geadas, Mahak Sharma, Heinz G. Remold, and Michael B. Brenner. Lysosome-mediated plasma membrane repair is dependent on the small GTPase, Arl8b, and determines cell death type in Mycobacterium tuberculosis infection. Journal of Immunology, 200(9): 3160-3169 (2018). #equal contribution and *co-corresponding authors.

6. Aastha Sindhwani, Subhash B. Arya, Harmeet Kaur, Divya Jagga, Amit Tuli and Mahak Sharma. Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication. PLos Pathogens, 13(10):e1006700 (2017).

7. Rituraj Marwaha, Subhash B. Arya, Divya Jagga, Harmeet Kaur, Amit Tuli* and Mahak Sharma*. The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes. Journal of Cell Biology, 216(4): 1051-1070 (2017). *co-corresponding authors.

8. Poomy Pandey, Bailee Sliker, Haley L. Peters, Amit Tuli, Jonathan Herskovitz, Kaitlin Smits, Abhilasha Purohit, Rakesh K. Singh, Jixin Dong, Surinder K. Batra, Donald W. Coulter and Joyce C. Solheim. Amyloid precursor protein and amyloid precursor-like protein 2 in cancer. Oncotarget, 7(15): 19430-19444 (2016).

9. Xavier Michelet, Salil Garg, Benjamin J. Wolf, Amit Tuli, Paola Ricciardi-Castagnoli and Michael B. Brenner. MHC Class II presentation is controlled by the lysosomal small GTPase, Arl8b. Journal of Immunology, 194(5): 2079-2088 (2015).

10. Amit Tuli*, Jerome Thiery, Ashley M. James, Xavier Michelet, Mahak Sharma, Salil Garg, Keri B. Sanborn, Jordan S. Orange, Judy Lieberman and Michael B. Brenner*. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Molecular Biology of the Cell, 24(23): 3721-3735 (2013). *co-corresponding author.

11. Haley L. Peters, Amit Tuli, Xiaojian Wang, Cuiling Liu, Zenggang Pan, Michel M. Ouellette, Michael A. Hollingsworth, Richard G. MacDonald and Joyce C. Solheim. Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells. International Journal of Oncology, 41(4): 1464-1474 (2012).

12. Laura C. Simone, Amit Tuli, Peter D. Simone, Xiaojian Wang and Joyce C. Solheim. Analysis of major histocompatibility complex class I folding: novel insights into intermediate forms. Tissue Antigens, 79(4):249-262 (2012).

13. Patrick J. Brennan, Raju V. V. Tatituri, Manfred Brigl, Edy Y. Kim, Amit Tuli, Joseph P. Sanderson, Stephan D. Gadola, Fong-Fu Hsu, Gurdyal S. Besra and Michael B. Brenner. Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nature Immunology, 12(12):1202-1211 (2011).

14. Salil Garg, Mahak Sharma, Cindy Ung, Amit Tuli, Duarte C. Barral, David L. Hava, Natacha Veerapen, Gurdyal S. Besra, Nir Hacohen and Michael B. Brenner. Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b. Immunity, 35(2):182-193 (2011).

15. Haley L. Peters, Amit Tuli, Mahak Sharma, Naava Naslavsky, Steve Caplan, Richard G. MacDonald and Joyce C. Solheim. Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2. Immunologic Research, 51(1):39-44 (2011).

16. Laura C. Simone, Xiaojian Wang, Amit Tuli and Joyce C. Solheim. Effect of the tapasin mutant on the assembly of the mouse MHC class I molecule H2-Kd. Immunology and Cell Biology, 88(1):57-62 (2010).

17. Amit Tuli, Mahak Sharma, Haley Capek, Naava Naslavsky, Steve Caplan and Joyce C. Solheim. Mechanism for amyloid precursor-like protein 2 enhancement of major histocompatibility complex class I molecule degradation. Journal of Biological Chemistry, 284(49):34296-34307 (2009).

18. Amit Tuli, Mahak Sharma, Xiaojian Wang, Steven Cate, William H. Hildebrand, Naava Naslavsky, Steve Caplan and Joyce C. Solheim. Amyloid precursor-like protein 2 association with HLA class I molecules. Cancer Immunology & Immunotherapy, 58(9):1419-1431 (2009).

19. Xiaojian Wang, Laura C. Simone, Amit Tuli and Joyce C. Solheim. Comparative analysis of the impact of a free cysteine in tapasin on the maturation and surface expression of murine MHC class I allotypes. International Journal of Immunogenetics, 36(3):183-187 (2009).

20. Laura C. Simone, Xiaojian Wang, Amit Tuli, Mary M. Mcllhaney and Joyce C. Solheim. Influence of the tapasin C-terminus on the assembly of MHC class I allotypes. Immunogenetics, 61(1): 43-54 (2009).

21. Xuede Lin, Xiaojian Wang, Haley Capek, Laura Groening, Amit Tuli, Chantey Morris, Adrian J. Reber and Joyce C. Solheim. Major histocompatibility complex class I molecule expression and stability on human breast tumor cell lines. Cancer Immunology & Immunotherapy, 58(5):729-736 (2009).

22. Amit Tuli, Mahak Sharma, Mary M. McIlhaney, James E. Talmadge, Naava Naslavsky, Steve Caplan and Joyce C. Solheim. Amyloid precursor-like protein 2 increases the endocytosis, instability and turnover of the H2-Kd MHC class I molecule. Journal of Immunology, 181: 1978-1987 (2008).

23. Amit Tuli, Mahak Sharma, Mary M. McIlhaney, Naava Naslavsky, Steve Caplan and Joyce C. Solheim. Specificity of amyloid precursor-like protein 2 interactions with MHC class I molecules. Immunogenetics, 60 (6): 303-313 (2008).

24. Abdelkader E. Ashour, Xuede Lin, Xiaojian Wang, Hēth R. Turnquist, Nicole M. Burns, Anguraj Sadanandam, Amit Tuli, Rakesh K. Singh, James E. Talmadge and Joyce C. Solheim. CCL21 is an effective surgical neoadjuvant for treatment of mammary tumors. Cancer Biology and Therapy, 6 (8): 1206-1210 (2007).