Education
Ph.D. in Neuroscience, Albert Einstein College of Medicine, 2010
Current position
He is a postdoctoral fellow in the Department of Cell Biology at Harvard University. His research focuses on understanding the role of neuroinflammation in neurodegenerative diseases
Publications
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Ofengeim, D. and Yuan, J. (2013). Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nature Rev. Mol. Cell. Biology 14(11):727-36.
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Vakifahmetoglu-Norberg, H., Kim, M., Xia, H. G., Iwanicki, M. P., Ofengeim, D., Coloff, J. L., Pan, L., Ince, T. A., Kroemer, G., Brugge, J. S. and Yuan, J. (2013). Chaperone-mediated autophagy degrades mutant p53. Genes Dev 27(15): 1718-1730.
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Ofengeim, D., Shi, P., Miao, B., Fan, J., Xia, X., Fan, Y., Lipinski, M. M., Hashimoto, T., Polydoro, M., Yuan, J., Wong, S. T. and Degterev, A. (2012). Identification of small molecule inhibitors of neurite loss induced by Abeta peptide using high content screening. J Biol Chem 287(12): 8714-8723.
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Ofengeim, D., Chen, Y. B., Miyawaki, T., Li, H., Sacchetti, S., Flannery, R. J., Alavian, K. N., Pontarelli, F., Roelofs, B. A., Hickman, J. A., Hardwick, J. M., Zukin, R. S. and Jonas, E. A. (2012). N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death. Nat Neurosci 15(4): 574-580.
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Miyawaki, T., Ofengeim, D.*, Noh, K. M., Latuszek-Barrantes, A., Hemmings, B. A., Follenzi, A. and Zukin, R. S. (2009). The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death. Nat Neurosci 12(5): 618-626. (*authors contributed equally)
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Miyawaki, T., Mashiko, T., Ofengeim, D., Flannery, R. J., Noh, K. M., Fujisawa, S., Bonanni, L., Bennett, M. V., Zukin, R. S. and Jonas, E. A. (2008). Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Proc Natl Acad Sci U S A 105(12): 4892-4897.
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Bonanni, L., Chachar, M., Jover-Mengual, T., Li, H., Jones, A., Yokota, H., Ofengeim, D., Flannery, R. J., Miyawaki, T. and Cho, C.-H. (2006). Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain. The Journal of neuroscience 26(25): 6851-6862.