Education

Ph.D in Biological Sciences, The University of Waikato, Hamilton, New Zealand, 2007

Current Position

Principal  Investigator,  Cell  &  Molecular  Biology  Group,  Singapore  Institute  for  Clinical  Sciences, Agency for Science, Technology and Research (A*STAR), Singapore

Publications (since 2004)

1. Ge, X., Sathiakumar, D., Lua, B. J., Kukreti, H., Lee, M. and McFarlane, C. (2016). Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes. Int J Obes (Lond).

2. Leow, S. C., Poschmann, J., Too, P. G., Yin, J., Joseph, R., McFarlane, C., Dogra, S., Shabbir, A., Ingham, P. W., Prabhakar, S., Leow, M. K., Lee, Y. S., Ng, K. L., Chong, Y. S., Gluckman, P. D. and Stunkel, W. (2016). The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis. Development 143(6): 950-961.
3. Sharma, M., McFarlane, C., Kambadur, R., Kukreti, H., Bonala, S. and Srinivasan, S. (2015). Myostatin: expanding horizons. IUBMB Life 67(8): 589-600.
4. Chandrashekar, P., Manickam, R., Ge, X., Bonala, S., McFarlane, C., Sharma, M., Wahli, W. and Kambadur, R. (2015). Inactivation of PPARbeta/delta adversely affects satellite cells and reduces postnatal myogenesis. Am J Physiol Endocrinol Metab 309(2): E122-131.
5. Shenoy, P. S., Bose, B., Sharma, M., McFarlane, C. and Kambadur, R. (2014). Lack of myostatin reduces MyoD induced myogenic potential of primary muscle fibroblasts. J Cell Biochem 115(11): 1908-1917.
6. Sharma, M., Juvvuna, P. K., Kukreti, H. and McFarlane, C. (2014). Mega roles of microRNAs in regulation of skeletal muscle health and disease. Front Physiol 5: 239.
7. McFarlane, C., Vajjala, A., Arigela, H., Lokireddy, S., Ge, X., Bonala, S., Manickam, R., Kambadur, R. and Sharma, M. (2014). Negative auto-regulation of myostatin expression is mediated by Smad3 and microRNA-27. PLoS One 9(1): e87687.
8. Sriram, S., Subramanian, S., Juvvuna, P. K., Ge, X., Lokireddy, S., McFarlane, C. D., Wahli, W., Kambadur, R. and Sharma, M. (2014). Myostatin augments muscle-specific ring finger protein-1 expression through an NF-kB independent mechanism in SMAD3 null muscle. Mol Endocrinol 28(3): 317-330.
9. Khoo, C. M., Leow, M. K., Sadananthan, S. A., Lim, R., Venkataraman, K., Khoo, E. Y., Velan, S. S., Ong, Y. T., Kambadur, R., McFarlane, C., Gluckman, P. D., Lee, Y. S., Chong, Y. S. and Tai, E. S. (2014). Body fat partitioning does not explain the interethnic variation in insulin sensitivity among Asian ethnicity: the Singapore adults metabolism study. Diabetes 63(3): 1093-1102.
10. Kukreti, H., Amuthavalli, K., Harikumar, A., Sathiyamoorthy, S., Feng, P. Z., Anantharaj, R., Tan, S. L., Lokireddy, S., Bonala, S., Sriram, S., McFarlane, C., Kambadur, R. and Sharma, M. (2013). Muscle-specific microRNA1 (miR1) targets heat shock protein 70 (HSP70) during dexamethasone-mediated atrophy. J Biol Chem 288(9): 6663-6678.
11. Sharma, M., Kambadur, R., Sriram, S., Lokireddy, S. and McFarlane, C. D. (2013). Molecular targets of cancer cachexia: Opportunities for pharmanutritional approaches. PharmaNutrition 2(3): 126-­28.
12. Lokireddy, S., Wijesoma, I. W., Sze, S. K., McFarlane, C., Kambadur, R. and Sharma, M. (2012). Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Am J Physiol Cell Physiol 303(5): C512-529.
13. Ge, X., Vajjala, A., McFarlane, C., Wahli, W., Sharma, M. and Kambadur, R. (2012). Lack of Smad3 signaling leads to impaired skeletal muscle regeneration. Am J Physiol Endocrinol Metab 303(1): E90-102.
14. Zhang, C., Tan, C. K., McFarlane, C., Sharma, M., Tan, N. S. and Kambadur, R. (2012). Myostatin-null mice exhibit delayed skin wound healing through the blockade of transforming growth factor-beta signaling by decorin. Am J Physiol Cell Physiol 302(8): C1213-1225.
15. Zhang, C., McFarlane, C., Lokireddy, S., Masuda, S., Ge, X., Gluckman, P. D., Sharma, M. and Kambadur, R. (2012). Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice. Diabetologia 55(1): 183-193.
16. Lokireddy, S., Mouly, V., Butler-Browne, G., Gluckman, P. D., Sharma, M., Kambadur, R. and McFarlane, C. (2011). Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteins. Am J Physiol Cell Physiol 301(6): C1316-1324.
17. Sriram, S., Subramanian, S., Sathiakumar, D., Venkatesh, R., Salerno, M. S., McFarlane, C. D., Kambadur, R. and Sharma, M. (2011). Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-kappaB. Aging Cell 10(6): 931-948.
18. McFarlane, C., Hui, G. Z., Amanda, W. Z., Lau, H. Y., Lokireddy, S., Xiaojia, G., Mouly, V., Butler-Browne, G., Gluckman, P. D., Sharma, M. and Kambadur, R. (2011). Human myostatin negatively regulates human myoblast growth and differentiation. Am J Physiol Cell Physiol 301(1): C195-203.
19. Ge, X., McFarlane, C., Vajjala, A., Lokireddy, S., Ng, Z. H., Tan, C. K., Tan, N. S., Wahli, W., Sharma, M. and Kambadur, R. (2011). Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts. Cell Res 21(11): 1591-1604.
20. Zhang, C., McFarlane, C., Lokireddy, S., Bonala, S., Ge, X., Masuda, S., Gluckman, P. D., Sharma, M. and Kambadur, R. (2011). Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway. Diabetologia 54(6): 1491-1501.
21. McFarlane, C., Sharma, M. and Kambadur, R. (2011). Role of myostatin and TGF-­beta signaling  in  skeletal  muscle  growth  and  development:  implications  for  sarcopenia.  In: Lynch, G. S. (Ed). Sarcopenia  –  Age-­Related  Muscle  Wasting  and  Weakness:  Mechanisms  and Treatments, Springer, p. 419-­447.
22. McFarlane, C., Sharma, M. and Kambadur, R. (2008). Myostatin is a procachectic growth factor during postnatal myogenesis. Curr Opin Clin Nutr Metab Care 11(4): 422-427.
23. McFarlane, C., Hennebry, A., Thomas, M., Plummer, E., Ling, N., Sharma, M. and Kambadur, R. (2008). Myostatin signals through Pax7 to regulate satellite cell self-renewal. Exp Cell Res 314(2): 317-329.
    
24. McFarlane, C., Plummer, E., Thomas, M., Hennebry, A., Ashby, M., Ling, N., Smith, H., Sharma, M. and Kambadur, R. (2006). Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent mechanism. J Cell Physiol 209(2): 501-514.
25. McFarlane, C., Langley, B., Thomas, M., Hennebry, A., Plummer, E., Nicholas, G., McMahon, C., Sharma, M. and Kambadur, R. (2005). Proteolytic processing of myostatin is auto-regulated during myogenesis. Dev Biol 283(1): 58-69.
26. Langley, B., Thomas, M., McFarlane, C., Gilmour, S., Sharma, M. and Kambadur, R. (2004). Myostatin  inhibits  rhabdomyosarcoma  cell  proliferation  through  an  Rb-­independent pathway. Oncogene 23(2): 524-5­34.