Andrew D. Doyle
  • Staff Scientist, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda Maryland
研究方向
  • Biochemistry
个人信息

教育背景

PhD, University of Connecticut, 2004

实验室信息

Kenneth Yamada Laboratory

研究方向

Cellular mechanotransduction, 3D cell migration, Extracellular matrices, focal adhesions

发表论文

1.Daley, W. P., Matsumoto, K., Doyle, A. D., Wang, S., DuChez, B. J., Holmbeck, K. and Yamada, K. M. (2017). Btbd7 is essential for region-specific epithelial cell dynamics and branching morphogenesis in vivo. Development 144(12): 2200-2211.
2.Doyle, A. D. (2016). Generation of 3D Collagen Gels with Controlled Diverse Architectures. Curr Protoc Cell Biol 72: 10 20 11-10 20 16.
3.Doyle, A. D. and Yamada, K. M. (2016). Mechanosensing via cell-matrix adhesions in 3D microenvironments. Exp Cell Res 343(1): 60-66.
4.Doyle, A. D., Carvajal, N., Jin, A., Matsumoto, K. and Yamada, K. M. (2015). Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions. Nat Commun 6: 8720.
5.Harunaga, J. S., Doyle, A. D. and Yamada, K. M. (2014). Local and global dynamics of the basement membrane during branching morphogenesis require protease activity and actomyosin contractility. Dev Biol 394(2): 197-205.
6.Hsu, J. C., Koo, H., Harunaga, J. S., Matsumoto, K., Doyle, A. D. and Yamada, K. M. (2013). Region-specific epithelial cell dynamics during branching morphogenesis. Dev Dyn 242(9): 1066-1077.
7.Suzuki, N., Fukushi, M., Kosaki, K., Doyle, A. D., de Vega, S., Yoshizaki, K., Akazawa, C., Arikawa-Hirasawa, E. and Yamada, Y. (2012). Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS. J Neurosci 32(34): 11586-11599.
8.Doyle, A. D., Kutys, M. L., Conti, M. A., Matsumoto, K., Adelstein, R. S. and Yamada, K. M. (2012). Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics. J Cell Sci 125(Pt 9): 2244-2256.
9.Doyle, A. D., Petrie, R. J., Kutys, M. L. and Yamada, K. M. (2013). Dimensions in cell migration. Curr Opin Cell Biol 25(5): 642-649.
10.Kutys, M.L., Doyle, A.D., Yamada, K.M. (2013). Regulation of cell adhesion and migration by cell-derived matrices. Exp Cell Res.
11.Ishikawa, M., Iwamoto, T., Nakamura, T., Doyle, A., Fukumoto, S. and Yamada, Y. (2011). Pannexin 3 functions as an ER Ca(2+) channel, hemichannel, and gap junction to promote osteoblast differentiation. J Cell Biol 193(7): 1257-1274.
12.Hakkinen, K. M., Harunaga, J. S., Doyle, A. D. and Yamada, K. M. (2011). Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices. Tissue Eng Part A 17(5-6): 713-724.
13.Iwamoto, T., Nakamura, T., Doyle, A., Ishikawa, M., de Vega, S., Fukumoto, S. and Yamada, Y. (2010). Pannexin 3 regulates intracellular ATP/cAMP levels and promotes chondrocyte differentiation. J Biol Chem 285(24): 18948-18958.
14.Doyle, A. D. (2009). Generation of micropatterned substrates using micro photopatterning. Curr Protoc Cell Biol Chapter 10: Unit 10 15.
15.etrie, R. J., Doyle, A. D. and Yamada, K. M. (2009). Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol 10(8): 538-549.
16.Even-Ram, S., Doyle, A. D., Conti, M. A., Matsumoto, K., Adelstein, R. S. and Yamada, K. M. (2007). Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk. Nat Cell Biol 9(3): 299-309.
17.Doyle, A. D. and Lee, J. (2005). Cyclic changes in keratocyte speed and traction stress arise from Ca2+-dependent regulation of cell adhesiveness. J Cell Sci 118(Pt 2): 369-379.
18.Doyle, A., Marganski, W. and Lee, J. (2004). Calcium transients induce spatially coordinated increases in traction force during the movement of fish keratocytes. J Cell Sci 117(Pt 11): 2203-2214.
19.Sadeghi, A., Doyle, A. D. and Johnson, B. D. (2002). Regulation of the cardiac L-type Ca2+ channel by the actin-binding proteins alpha-actinin and dystrophin. Am J Physiol Cell Physiol 282(6): C1502-1511.