助理编辑
Domenico Azarnia Tehran
  • Post-Doc, Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
研究方向
  • Biochemistry, Cell Biology, Neuroscience
个人信息

教育背景

University of Padova

实验室信息

Fan Liu lab
http://www.leibniz-fmp.de/research/molecular-physiology-and-cell-biology/research-groups/haucke/department.html

发表论文

https://pubmed.ncbi.nlm.nih.gov/?term=domenico+azarnia+tehran&sort=date
Azarnia Tehran D.#, Kochlamazashvili G., Pampaloni N. P., Sposini S., Shergill J. K., Lehmann M., Pashkova N., Schmidt C., Löwe D., Napieczynska H., Heuser A., Plested A. J. R., Perrais D., Piper R. C., Haucke V.# and Maritzen T#. Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity. Sci Adv. 2022 May 27;8(21):eabl5032. doi: 10.1126/sciadv.abl5032. Epub 2022 May 25.

Azarnia Tehran D. and Maritzen T. Endocytic proteins: An expanding repertoire of presynaptic functions. Curr Opin Neurobiol. 2022 Apr;73:102519. doi: 10.1016/j.conb.2022.01.004. Epub 2022 Feb 22.

Kuijpers M.*, Azarnia Tehran D.*, Haucke V. and Soykan T. The axonal endolysosomal and autophagic systems. J Neurochem. 2021 Aug;158(3):589-602. doi: 10.1111/jnc.15287. Epub 2021 Jan 15.

Azarnia Tehran D.*, Lopez-Hernandez T.* and Maritzen T. Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations. Cells. 2019 Oct 29;8(11):1345. doi: 10.3390/cells8111345.

Azarnia Tehran D.# and Pirazzini M.#. Preparation of Cerebellum Granule Neurons from mouse or rat pups and evaluation of clostridial neurotoxin activity and their inhibitors by Western blot and immunohistochemistry. Bio Protoc. 2018 Jul 5;8(13):e2918. doi: 10.21769/BioProtoc.2918. eCollection 2018 Jul 5.

Azarnia Tehran D. # and Pirazzini M.#. Novel botulinum neurotoxins: exploring below the iceberg tip. Toxins (Basel). 2018 May 10;10(5):190. doi: 10.3390/toxins10050190.

Azarnia Tehran D.*, Kuijpers M.* and Haucke V. Presynaptic endocytic factors in autophagy and neurodegeneration. Curr Opin Neurobiol. 2018 Feb;48:153-159. doi: 10.1016/j.conb.2017.12.018. Epub 2018 Jan 6.

Azarnia Tehran D.#, Pirazzini M.#, Leka O., Mattarei A., Lista F., Binz T., Rossetto O., Montecucco C. Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals. Cell Microbiol. 2017 Feb;19(2). doi: 10.1111/cmi.12647. Epub 2016 Aug 4.

Zornetta I.*, Azarnia Tehran D.*, Arrigoni G.*, Anniballi F., Bano L., Leka O., Zanotti G., Binz T., Montecucco C. The first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain. Sci Rep. 2016 Jul 22;6:30257. doi: 10.1038/srep30257.

Azarnia Tehran D.*, Zanetti G.*, Oneda L., Florigio L., Fillo S., Binz T., Clifford C.C., Rossetto O., Montecucco C., Paradisi C., Mattarei A., Pirazzini M. A novel inhibitor prevents the peripheral neuroparalysis of botulinum neurotoxins. Sci Rep. 2015 Dec 16;5:17513. doi: 10.1038/srep17513.

Zanetti G.*, Azarnia Tehran D.*, Pirazzini M., Binz T., Shone C.C., Fillo S., Lista F., Rossetto O., Montecucco C. Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism. Biochem Pharmacol. 2015 Dec 1;98(3):522-30. doi: 10.1016/j.bcp.2015.09.023. Epub 2015 Oct 9.

Pirazzini M.*, Azarnia Tehran D.*, Zanetti G., Megighian A., Scorzeto M., Fillo S., Shone C.C., Binz T., Rossetto O., Lista F., Montecucco C. Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins. Cell Rep. 2014 Sep 25;8(6):1870-1878. doi: 10.1016/j.celrep.2014.08.017. Epub 2014 Sep 15.

Pirazzini M, Azarnia Tehran D., Zanetti G., Rossetto O., Montecucco C. Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals. Toxicon. 2018 Jun 1;147:32-37. Epub 2017 Oct 28.

Anniballi F., Fillo S., Giordani F., Auricchio B., Azarnia Tehran D., Di Stefano E., Mandarino G., De Medici D., Lista F. Multiple-locus variable number of tandem repeat analysis as a tool for molecular epidemiology of botulism. Infect Genet Evol. 2016 Dec;46:28-32. doi: 10.1016/j.meegid.2016.10.014. Epub 2016 Oct 19.

Schnell L., Mittler A.K., Mattarei A., Azarnia Tehran D., Montecucco C., Barth H. Semicarbazone EGA inhibits uptake of diphtheria toxin into human cells and protects cells from intoxication. Toxins (Basel). 2016 Jul 15;8(7):221. doi: 10.3390/toxins8070221.

Schnell L., Mittler A.K., Sadi M., Popoff M.R., Schwan C., Aktories K., Mattarei A., Azarnia Tehran D., Montecucco C., Barth H. EGA protects mammalian cells from Clostridium difficile CDT, Clostridium perfrigens iota toxin and Clostridium botulinum C2 toxin. Toxins (Basel). 2016 Apr 1;8(4):101. doi: 10.3390/toxins8040101.

Pirazzini M., Azarnia Tehran D., Leka O., Zanetti G., Rossetto O., Montecucco C. On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments. Biochim Biophys Acta. 2016 Mar;1858(3):467-74. doi: 10.1016/j.bbamem.2015.08.014. Epub 2015 Aug 22.

Giordani F., Fillo S., Anselmo A., Palozzi A.M., Fortunato A., Gentile B., Azarnia Tehran D., Ciammaruconi A., Spagnolo F., Pittiglio V., Anniballi F., Auricchio B., De Medici D., Lista F. Genomic characterization of italian Clostridium botulinum group I strains. Infect Genet Evol. 2015 Dec;36:62-71. doi: 10.1016/j.meegid.2015.08.042. Epub 2015 Sep 1.

Pirazzini M., Azarnia Tehran D., Zanetti G., Lista F., Binz T., Shone CC., Rossetto O., Montecucco C. The thioredoxin reductase-thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles. Toxicon. 2015 Dec 1;107(Pt A):32-6. doi: 10.1016/j.toxicon.2015.06.019. Epub 2015 Jun 27.