Statistical significance was assessed through Wilcoxon signed rank test at the P = 0.05 level unless otherwise stated. Values are reported as box plots unless otherwise stated. Error bars indicate mean ± SEM. On each box, the central mark indicates the median, and the bottom and top edges of the box indicate the 25th and 75th percentiles, respectively. The whiskers extend to the most extreme data points not considered outliers, and the outliers are plotted individually using the “▲” symbol. For datasets with n ≤ 10, the individual data points are also shown.