De novo motifs were searched with HOMER (56) in sequences ±100 bp around summits of promoter, enhancer, or repressed S100A8/A9 peaks against corresponding control regions from promoter, enhancer, and repressed DNase I hypersensitive sites lacking S100A8/A9 association. The enriched motifs (according to hypergeometric P values) were compared with JASPAR CORE collection of vertebrate motifs (57) for scoring their similarity (by HOMER), which were less than or equal to 1 (complete similarity). Discovered motifs with similarity score >0.9 were selected for subsequent analyses.

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