The comparison of two groups or data points was performed by the two-tailed t-test. Multiple comparisons were analyzed by two-way analysis of variance (ANOVA). Survival curves were constructed according to the GOBO method and compared using the log-rank (Mantel-Cox) test. P ≤ 0.05 were considered statistically significant. Results from xenograft experiments and clinical breast samples were analyzed by GraphPad Prism 7.

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