Fresh whole blood was obtained from 8 healthy donors (HD), 8 SLE, and 7 SjS patients under an approved IRB protocol. Patients were recruited from the University of Washington Medical Center. For SLE, disease activity was measured using the SLE Disease Activity Index 2000 (SLEDAI-2K). Patients treated with biologics within the last 6 months or suspected of having acute infections were excluded from the analysis. HD with no history of autoimmune diseases or current infections were used. Additional information about the SjS and SLE study subjects included in the analysis is shown in Supplemental Table 1.