Twenty consecutively enrolled lymphoma patients (5 with Hodgkin lymphoma, 14 with Non-Hodgkin lymphoma, 1 with high clinical suspicion of lymphoma) undergoing 18F-FDG PET examination (on clinical indication) were included. In 6 of these the examination was performed for initial staging, in 12 after systemic treatment and in the 2 remaining patients for suspicion of recurrence.

Detailed patient and imaging characteristics are provided in Supplemental Table S1. Mean patient age (range) was 50 (23–84) years and mean patient weight (range) was 81 (47–130) kg. Following joint EANM procedure guidelines for 18F-FDG PET/CT in tumor imaging, a mean±standard deviation (SD) activity of 340±72 MBq (corresponding to 4.2±0.4 MBq/kg bodyweight) 18F-FDG was injected intravenously. PET/CT data were acquired after a mean±SD time interval of 73±11 min.