The following primary antibodies were used for this study: MET monoclonal antibody (3D4) (37–0100; Invitrogen); Ago2 Monoclonal Antibody (MA5–23515, Invitrogen); mouse IgG (sc-2025; Santa Cruz); FITC anti-STAT3 Phospho (Tyr705) (Biolegend); anti-mouse CD45 Antibody (30-F11, Biolegend); anti mouse MET antibody (ab51067, Abcam); anti-mouse CD11b Antibody (M1/70, Invitrogen); anti-mouse F4/80 Antibody (BM8; Biolegend); anti-mouse lineage cocktail (145-2C11; RB6-8C5; RA3-6B2; Ter-119; M1/70; Biolegend) and anti-mouse CD274 (PDL1) (10F.9G2; Biolegend), and anti-mouse Vimentin APC-conjugated Antibody (IC2105A, &D). hsa-miR-34a-5p mimic and inhibitors were obtained from Ambion (Thermofisher). pLL3.7 was a gift from Luk Parijs (Addgene plasmid # 11795). pLL3.7 miR-34a-5p was a gift from Judy Lieberman (Addgene plasmid # 25791). The MET vector used in this study included both coding sequence and 3’UTR of MET and was constructed in a pBABE vector. LNA-miR-34a-5p miR was provided by Exiqon. The Lipofectamine RNAiMAX (Invitrogen) or Lipofectamine 2000 (Invitrogen) were used for transfection experiments.