HSA, amino-polyethylene glycol-amino (Amine-PEG-Amine, MW 4K), ICG fluorescent dye, and nuclear targeting peptide TAT (human immunodeficiency virus 1 [HIV-1]-transactivator protein, TAT) were purchased from Sigma–Aldrich (St. Louis, MI, USA). N-hydroxysuccinimide (NHS) and N-(3-dimethyl aminopropyl)-N’-ethyl carbodiimide (EDC) were purchased from Aladdin reagent. Fetal bovine serum (FBS) was purchased from Hyclone. RPMI 1640 medium, phosphate-buffered saline (PBS), and 0.25% trypsin were purchased from Gibco (Grand Island, NY, USA). The Cell Counting Kit-8 (CCK-8) kit was purchased from the Tongren Institute of Chemistry (Japan); single-cell gel electrophoresis kit was purchased from Beijing Ximeijie Technology (Beijing, China); Annexin fluorescein isothiocyanate/propidium iodide (FITC/PI) apoptosis detection kit was purchased from BD Pharmingen (East Rutherford, NJ, USA,); Tris-HCl pH 8.8 buffer was purchased from Biyuntian Biotechnology Co., Ltd. (China).