Patients were stratified according to eGFR on admission into two groups based on the presence of chronic kidney disease (CKD): patients with an eGFR of at least 60 ml/min/1.73 m2 were defined as non-CKD patients and those with an eGFR below 60 ml/min/1.73 m2 were defined as CKD patients. This definition is based on the established KDIGO guidelines [7]. GFR was estimated by using the CKD-EPI formula. For the present analysis, four different definitions of AKI were evaluated:

AKIN 1 definition: according to the AKIN definition with AKI defined as a relative increase in sCR of at least 1.5 fold (50% increase) from the baseline value;

AKIN 2 definition: according to the AKIN definition with AKI defined as an absolute increase in sCR of at least 0.3 mg/dl;

RIFLE definition: according to the eGFR-based RIFLE classification with AKI defined as a decrease in eGFR of more than 25% from the baseline eGFR value;

CIN definition: according to the definition of AKI as an absolute increase in sCR of at least 0.5 mg/dl.

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