We used the medical charts and laboratory electronic database to collect demographic data; diagnoses; comorbidities; disease status on ICU admission; CVC information, treatment interventions; clinical symptoms; and laboratory values at the onset of the suspected CRBSI; the results of microbial cultures within 24 h before catheter removal; and 30-day mortality. Two classification systems were used to assess patients with times between ICU admission and the development of a suspected CRBSI: The Acute Physiology and Chronic Health Evaluation (APACHE) II score and Sequential Organ Failure Assessment (SOFA) score [2,6].

To assess the possible risk factors, we used the transformed data that were stratified according to the SIRS criteria of International Sepsis Definitions Conference (ISDC), including five aspects variable: general variable, inflammatory variables, hemodynamic variables, organ dysfunction variables, tissue perfusion variables. [13] However, for plasma glucose levels, we used the highest mean level three days before CVC removal, and the transformed data were stratified according to the values recommended in the international guidelines, with a plasma glucose target ≤ 10 mmol/L [14].

The outcome of this study was 30-day mortality in patients with suspected CRBSIs, and the mortality after 30 days was considered to be less likely to be related to CRBSIs [11,12].