Fifty male Wistar rats (190–220 g) were utilized in the existing study, conducted at the Animal Facility, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia. Rats were kept on a 12-h light-dark cycle and a persistent temperature of 22 ± 2°C. The experimental protocol involving animals and their care was conducted in compliance with the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) international guidelines and approved in advance by Research Ethics Committee, Faculty of Pharmacy, King Abdulaziz University (Approval # PH-121-41).