A prospective, open-label, multicenter exploratory study with active and comparator arms was conducted from January 8, 2018, to January 7, 2020, at 3 study sites. Participants were recruited from among new patients with chronic pain conditions who were referred to 2 tertiary academic pain centers in Toronto, Ontario, Canada (Toronto General Hospital [TGH] and Toronto Western Hospital [TWH]) and a rural pain clinic in Ontario (the Iroquois Falls Family Health Team [IFFHT] pain clinic in Iroquois Falls, Ontario). All patients had pain of moderate-to-severe intensity that had persisted for at least three months. All patients, regardless of use of the Manage My Pain app, received the standard of care for the particular clinic, which included interventions such as medication management, psychological therapy, and physiotherapy.