神经科学

分类

    现刊
    A Method to Quantify Drosophila Behavioral Activities Induced by GABAA Agonist Muscimol
    GABAA激动剂毒蝇蕈醇诱导果蝇行为活动的量化方法
    作者:M. Rezaul Karim日期:04/20/2021,浏览量:64,Q&A: 0

    Muscimol is a psychoactive isoxazole derived from the mushroom Amanita muscaria. As a potent GABAA receptor agonist, muscimol suppresses the activity of the central nervous system, reduces anxiety and induces sleep. We investigated the effects of

    ...
    Single or Repeated Ablation of Mouse Olfactory Epithelium by Methimazole
    甲巯咪唑单次或多次消融小鼠嗅上皮细胞
    作者:Sofia Håglin, Staffan Bohm and Anna Berghard日期:04/20/2021,浏览量:69,Q&A: 0

    Odor-detecting olfactory sensory neurons residing in the nasal olfactory epithelium (OE) are the only neurons in direct contact with the external environment. As a result, these neurons are subjected to chemical, physical, and infectious insults,

    ...
    Production of Phenotypically Uniform Human Cerebral Organoids from Pluripotent Stem Cells
    从多能干细胞生产表型一致的人类大脑类器官
    作者:Adam Sivitilli, Parisa Ghiasi and Liliana Attisano日期:04/20/2021,浏览量:22,Q&A: 0

    Recent advances in stem cell technology have allowed researchers to generate 3D cerebral organoids (COs) from human pluripotent stem cells (hPSCs). Indeed, COs have provided an unprecedented opportunity to model the developing human brain in a 3D

    ...
    Single-unit Recording in Awake Behaving Non-human Primates
    非人类灵长类动物清醒时的单细胞记录
    作者:Mengxi Yun, Masafumi Nejime and Masayuki Matsumoto日期:04/20/2021,浏览量:34,Q&A: 0

    Non-human primates (NHPs) have been widely used as a species model in studies to understand higher brain functions in health and disease. These studies employ specifically designed behavioral tasks in which animal behavior is well-controlled, and

    ...
    Transfection and Activation of CofActor, a Light and Stress Gated Optogenetic Tool, in Primary Hippocampal Neuron Cultures
    一种在原代海马神经元培养能辅助因子的转染和激活的光和应激门控的光遗传学工具
    作者:Wyatt P. Bunner, Rachel Dodson, Robert M. Hughes and Erzsebet M. Szatmari日期:04/20/2021,浏览量:0,Q&A: 0

    Proteins involved in neurodegeneration can be coupled with optogenetic reagents to create rapid and sensitive reporters to provide insight into the biochemical processes that mediate the progression of neurodegenerative disorders, including

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    Development of a Chemical Reproductive Aging Model in Female Rats
    雌性大鼠化学生殖衰老模型的建立

    Women are born with an abundant but finite pool of ovarian follicles, which naturally and progressively decreased during their reproductive years until menstrual periods stop permanently (menopause). Perimenopause represents the transition from

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    Development of a Chemical Reproductive Aging Model in Female Rats
    雌性大鼠化学生殖衰老模型的建立
    [Abstract]

    Women are born with an abundant but finite pool of ovarian follicles, which naturally and progressively decreased during their reproductive years until menstrual periods stop permanently (menopause). Perimenopause represents the transition from reproductive to non-reproductive life. It is usually characterized by neuroendocrine, metabolic and

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    Transfection and Activation of CofActor, a Light and Stress Gated Optogenetic Tool, in Primary Hippocampal Neuron Cultures
    一种在原代海马神经元培养能辅助因子的转染和激活的光和应激门控的光遗传学工具
    作者:Wyatt P. Bunner, Rachel Dodson, Robert M. Hughes and Erzsebet M. Szatmari日期:04/20/2021,浏览量:0,Q&A: 0
    [Abstract]

    Proteins involved in neurodegeneration can be coupled with optogenetic reagents to create rapid and sensitive reporters to provide insight into the biochemical processes that mediate the progression of neurodegenerative disorders, including Alzheimer’s Disease (AD). We have recently developed a novel optically-responsive tool (the

    ...
    Single-unit Recording in Awake Behaving Non-human Primates
    非人类灵长类动物清醒时的单细胞记录
    作者:Mengxi Yun, Masafumi Nejime and Masayuki Matsumoto日期:04/20/2021,浏览量:34,Q&A: 0
    [Abstract]

    Non-human primates (NHPs) have been widely used as a species model in studies to understand higher brain functions in health and disease. These studies employ specifically designed behavioral tasks in which animal behavior is well-controlled, and record neuronal activity at high spatial and temporal resolutions while animals are performing the

    ...
    Production of Phenotypically Uniform Human Cerebral Organoids from Pluripotent Stem Cells
    从多能干细胞生产表型一致的人类大脑类器官
    作者:Adam Sivitilli, Parisa Ghiasi and Liliana Attisano日期:04/20/2021,浏览量:22,Q&A: 0
    [Abstract]

    Recent advances in stem cell technology have allowed researchers to generate 3D cerebral organoids (COs) from human pluripotent stem cells (hPSCs). Indeed, COs have provided an unprecedented opportunity to model the developing human brain in a 3D context, and in turn, are suitable for addressing complex neurological questions by leveraging

    ...
    Single or Repeated Ablation of Mouse Olfactory Epithelium by Methimazole
    甲巯咪唑单次或多次消融小鼠嗅上皮细胞
    作者:Sofia Håglin, Staffan Bohm and Anna Berghard日期:04/20/2021,浏览量:69,Q&A: 0
    [Abstract]

    Odor-detecting olfactory sensory neurons residing in the nasal olfactory epithelium (OE) are the only neurons in direct contact with the external environment. As a result, these neurons are subjected to chemical, physical, and infectious insults, which may be the underlying reason why neurogenesis occurs in the OE of adult mammals. This feature

    ...
    A Method to Quantify Drosophila Behavioral Activities Induced by GABAA Agonist Muscimol
    GABAA激动剂毒蝇蕈醇诱导果蝇行为活动的量化方法
    作者:M. Rezaul Karim日期:04/20/2021,浏览量:64,Q&A: 0
    [Abstract]

    Muscimol is a psychoactive isoxazole derived from the mushroom Amanita muscaria. As a potent GABAA receptor agonist, muscimol suppresses the activity of the central nervous system, reduces anxiety and induces sleep. We investigated the effects of muscimol on Drosophila behavior. Drosophila behavioral assays are powerful tools that are used to

    ...
    Cranioplastic Surgery and Acclimation Training for Awake Mouse fMRI
    清醒小鼠fMRI的颅成形手术及适应训练
    作者:Tomokazu Tsurugizawa, Kota Tamada, Clement Debacker, Andrew Zalesky and Toru Takumi日期:04/05/2021,浏览量:198,Q&A: 0
    [Abstract]

    MRI is a promising tool for translational research to link brain function and structure in animal models of disease to patients with neuropsychiatric disorders. However, given that mouse functional MRI (fMRI) typically relies on anesthetics to suppress head motion and physiological noise, it has been difficult to directly compare brain fMRI in

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    Imaging Microtubules in vitro at High Resolution while Preserving their Structure
    保留微管结构同时在体外对其进行高分辨率成像
    作者:Camille Cuveillier, Yasmina Saoudi, Isabelle Arnal and Christian Delphin日期:04/05/2021,浏览量:204,Q&A: 0
    [Abstract]

    Microtubules (MT) are the most rigid component of the cytoskeleton. Nevertheless, they often appear highly curved in the cellular context and the mechanisms governing their overall shape are poorly understood. Currently, in vitro microtubule analysis relies primarily on electron microscopy for its high resolution and Total Internal Reflection

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    A Time Duration Discrimination Task for the Study of Elapsed Time Processing in Rats
    用于研究大鼠执行时间的时程辨别任务
    [Abstract]

    Space and time are both essential features of episodic memory. However, while spatial tasks have been used effectively to study the behavioral relevance of place cells, the behavioral paradigms utilized for the study of time cells have not used time duration as a variable that animals need to be aware of to solve the task. In order to evaluate how

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    Investigate Synaptic Vesicles Mobility in Neuronal Culture Axons by FRAP Imaging
    用FRAP成像技术研究神经元轴突中突触囊泡的移动
    作者:Xiao Min Zhang, Fabrice P. Cordelieres and Etienne Herzog日期:03/20/2021,浏览量:603,Q&A: 0
    [Abstract]

    Synaptic vesicles (SVs) are clustered in the presynaptic terminals and consistently trafficking along axons. Based on their release features, SVs are classified into different “pools”. Imaging of SVs that are traveling among multiple presynaptic terminals has helped define a new pool named “SV super-pool”. Here we describe

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