神经科学

分类

    现刊
    An ex vivo Approach to Assess Mitochondrial ROS by Flow Cytometry in AAV-tagged Astrocytes in Adult Mice
    一种利用流式细胞术进行成年大鼠腺相关病毒标记星型胶质细胞中线粒体ROS水平的体外检测方法
    作者:Carlos Vicente-Gutierrez and Juan P. Bolaños日期:03/20/2020,浏览量:379,Q&A: 0
    Mitochondrial reactive oxygen species (mROS) are naturally produced signalling molecules extremely relevant for understanding both health- and disease-associated biological processes. The study of mROS in the brain is currently underway to decipher ...
    Optic Nerve Crush in Mice to Study Retinal Ganglion Cell Survival and Regeneration
    视神经挤压对小鼠视网膜神经节细胞存活和再生的影响
    作者:Evan G. Cameron, Xin Xia, Joana Galvao, Masoumeh Ashouri, Michael S. Kapiloff and Jeffrey L. Goldberg日期:03/20/2020,浏览量:168,Q&A: 0
    In diseases such as glaucoma, the failure of retinal ganglion cell (RGC) neurons to survive or regenerate their optic nerve axons underlies partial and, in some cases, complete vision loss. Optic nerve crush (ONC) serves as a useful model not only ...
    Phototactic T-maze Behavioral Assay for Comparing the Functionality of Color-sensitive Photoreceptor Subtypes in the Drosophila Visual System
    趋光T-迷宫行为分析用于果蝇视觉系统中色彩敏感光感应器亚型的比较
    作者:Hunter S. Shaw, Joe Larkin and Yong Rao日期:03/20/2020,浏览量:109,Q&A: 0
    The Drosophila retina contains light-sensitive photoreceptors (R cells) with distinct spectral sensitivities that allow them to distinguish light by its spectral composition. R7 and R8 photoreceptors are important for color vision, and can ...
    Shared Pheromonal Communication of Specific Fear Between Adult Sprague Dawley Rats
    成年SD大鼠特定恐惧的信息素通讯
    作者:Samantha J. Carew and Abhinaba Ghosh日期:03/20/2020,浏览量:144,Q&A: 0
    Rats are highly social animals, and mainly communicate with one another in two ways: through ultrasonic vocalizations and pheromones. Most research on pheromones has been dedicated those regarding sexual behavior, but more recently pheromones which ...
    Delayed Alternation Task for the Study of Spatial Working and Long Term Memory in Rats
    延迟交替任务用于研究大鼠空间工作记忆和长期记忆
    作者:Megi Hoxha and Marta Sabariego日期:03/05/2020,浏览量:399,Q&A: 0
    Memory systems can hold previously presented information for several seconds, bridging gaps between discontinuous events. It has been previously demonstrated that the hippocampus and the medial entorhinal cortex (mEC) are necessary for memory ...
    An ex vivo Approach to Assess Mitochondrial ROS by Flow Cytometry in AAV-tagged Astrocytes in Adult Mice
    一种利用流式细胞术进行成年大鼠腺相关病毒标记星型胶质细胞中线粒体ROS水平的体外检测方法
    作者:Carlos Vicente-Gutierrez and Juan P. Bolaños日期:03/20/2020,浏览量:379,Q&A: 0
    [Abstract] Mitochondrial reactive oxygen species (mROS) are naturally produced signalling molecules extremely relevant for understanding both health- and disease-associated biological processes. The study of mROS in the brain is currently underway to decipher their physiopathological roles and contributions in neurological diseases. Recent advances in this ...
    Optic Nerve Crush in Mice to Study Retinal Ganglion Cell Survival and Regeneration
    视神经挤压对小鼠视网膜神经节细胞存活和再生的影响
    作者:Evan G. Cameron, Xin Xia, Joana Galvao, Masoumeh Ashouri, Michael S. Kapiloff and Jeffrey L. Goldberg日期:03/20/2020,浏览量:168,Q&A: 0
    [Abstract] In diseases such as glaucoma, the failure of retinal ganglion cell (RGC) neurons to survive or regenerate their optic nerve axons underlies partial and, in some cases, complete vision loss. Optic nerve crush (ONC) serves as a useful model not only of traumatic optic neuropathy but also of glaucomatous injury, as it similarly induces RGC cell death ...
    Phototactic T-maze Behavioral Assay for Comparing the Functionality of Color-sensitive Photoreceptor Subtypes in the Drosophila Visual System
    趋光T-迷宫行为分析用于果蝇视觉系统中色彩敏感光感应器亚型的比较
    作者:Hunter S. Shaw, Joe Larkin and Yong Rao日期:03/20/2020,浏览量:109,Q&A: 0
    [Abstract] The Drosophila retina contains light-sensitive photoreceptors (R cells) with distinct spectral sensitivities that allow them to distinguish light by its spectral composition. R7 and R8 photoreceptors are important for color vision, and can be further classified into pale (p) or yellow (y) subtypes depending on the rhodopsin expressed. ...
    Shared Pheromonal Communication of Specific Fear Between Adult Sprague Dawley Rats
    成年SD大鼠特定恐惧的信息素通讯
    作者:Samantha J. Carew and Abhinaba Ghosh日期:03/20/2020,浏览量:144,Q&A: 0
    [Abstract] Rats are highly social animals, and mainly communicate with one another in two ways: through ultrasonic vocalizations and pheromones. Most research on pheromones has been dedicated those regarding sexual behavior, but more recently pheromones which signal danger to conspecifics have been identified in rodents. In fact, rats are capable of ...
    Delayed Alternation Task for the Study of Spatial Working and Long Term Memory in Rats
    延迟交替任务用于研究大鼠空间工作记忆和长期记忆
    作者:Megi Hoxha and Marta Sabariego日期:03/05/2020,浏览量:399,Q&A: 0
    [Abstract] Memory systems can hold previously presented information for several seconds, bridging gaps between discontinuous events. It has been previously demonstrated that the hippocampus and the medial entorhinal cortex (mEC) are necessary for memory retention over delay intervals in alternation tasks. Here we describe the delayed alternation task, a ...
    Hippocampal Unicellular Recordings and Hippocampal-dependent Innate Behaviors in an Adolescent Mouse Model of Alzheimer’s disease
    阿尔茨海默症幼鼠模型中海马单细胞记录和海马依赖先天性行为
    [Abstract] Transgenic mice have been used to make valuable contributions to the field of neuroscience and model neurological diseases. The simultaneous functional analysis of hippocampal cell activity combined with hippocampal dependent innate task evaluations provides a reliable experimental approach to detect fine changes during early phases of ...
    Induction of Temporal Lobe Epilepsy in Mice with Pilocarpine
    毛果芸香碱诱导小鼠颞叶癫痫
    作者:Muhammad Nauman Arshad and Janice R Naegele日期:02/20/2020,浏览量:420,Q&A: 0
    [Abstract] In the pilocarpine model of temporal lobe epilepsy (TLE) in rodents, systemic injections of pilocarpine induce continuous, prolonged limbic seizures, a condition termed “Status Epilepticus” (SE). With appropriate doses, many inbred strains of mice show behavioral seizures within an hour after pilocarpine is injected. With the behavioral scoring ...
    Method for Primary Epithelial Cell Culture from the Rat Choroid Plexus
    大鼠脉络丛原代上皮细胞培养方法
    作者:Valeria Lallai, Amina Ahmed and Christie D. Fowler日期:02/20/2020,浏览量:307,Q&A: 0
    [Abstract] The choroid plexus consists of a network of secretory epithelial cells localized throughout the lateral, third and fourth ventricles of the brain. Cerebrospinal fluid (CSF) is generated by the choroid plexus and released into the ventricular environment. This biofluid contains an enriched source of proteins, ions, and other signaling molecules for ...
    Implanting and Recycling Neuropixels Probes for Recordings in Freely Moving Mice
    自由运动小鼠 Neuropixels 探针的植入与回收
    作者:Ashley L. Juavinett, George Bekheet and Anne K. Churchland日期:02/05/2020,浏览量:584,Q&A: 0
    [Abstract] Recording neural activity in unrestricted animals is necessary to unravel the neural basis of ethological behaviors. Recently, Neuropixels probes have made important strides in improving yield and lowering noise, but have limited use cases in freely moving animals. Although there are a number of studies demonstrating the use of these probes in ...
    A Simple and Efficient Method for Concomitant Isolation and Culture of Enriched Astroglial and Microglial Cells from the Rat Spinal Cord
    一种简单有效的大鼠脊髓星形胶质细胞和小胶质细胞联合分离培养方法
    作者:Pooja Shree Mishra and Trichur R Raju日期:01/20/2020,浏览量:718,Q&A: 0
    [Abstract] Investigations into glial biology have contributed substantially in understanding the physiology and pathology of the nervous system. However, intricacies of the neuron-glial and glial-glial interactions in vivo present significant challenges while delineating the individual cell-type contributions, thus making the in vitro ...