联合作者(
Norbert Sträter Center for Biotechnology and Biomedicine, University Leipzig, Germany
1 protocol

Michael Schlömann Environmental Microbiology IÖZ, Technical University "Bergakademie" Freiberg, Germany
1 protocol

Stefan Rudolf Kaschabek Environmental Microbiology IÖZ, Technical University "Bergakademie" Freiberg, Germany
1 protocol

Janosch Alexander D. Gröning Environmental Microbiology IÖZ, Technical University "Bergakademie" Freiberg, Germany
1 protocol
联合评审(
Beatrice Li University of Oxford
7 protocols

Damián Lobato-Márquez Imperial College London
3 protocols

Lionel Schiavolin Université Libre de Bruxelles
12 protocols

Louise Jane Walport Imperial College London
5 protocols

评审
Christian Roth
  • University of York
研究方向
  • 生物物理学
  • 已发表 protocol 1

Education

Ph.D. in Structural Biology, University of Leipzig, Germany, 2013

Current position

PostDoc, University of York, UK (since 06/2013)

Publications

  1. Darby, J. F., Landström, J., Roth, C., He, Y., Davies, G. J. and Hubbard, R. E. (2014). Discovery of Selective Small‐Molecule Activators of a Bacterial Glycoside Hydrolase. Angew Chem Int Ed Engl. (Epub ahead of print)
  2. He, Y., Roth, C., Turkenburg, J. P. and Davies, G. J. (2014). Three-dimensional structure of a Streptomyces sviceus GNAT acetyltransferase with similarity to the C-terminal domain of the human GH84 O-GlcNAcase. Acta Crystallogr D Biol Crystallogr 70(Pt 1): 186-195.
  3. Roth, C., Wei, R., Oeser, T., Then, J., Follner, C., Zimmermann, W. and Strater, N. (2014). Structural and functional studies on a thermostable polyethylene terephthalate degrading hydrolase from Thermobifida fusca. Appl Microbiol Biotechnol 98(18): 7815-7823.
  4. Roth, C., Groning, J. A., Kaschabek, S. R., Schlomann, M. and Strater, N. (2013). Crystal structure and catalytic mechanism of chloromuconolactone dehalogenase ClcF from Rhodococcus opacus 1CP. Mol Microbiol 88(2): 254-267.
  5. Roth, C., Kaschabek, S. R., Groning, J. A., Handrek, T., Schlomann, M. and Strater, N. (2012). Crystallization and preliminary characterization of chloromuconolactone dehalogenase from Rhodococcus opacus 1CP. Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 5): 591-595.
  6. Lincke, J., Lassig, D., Kobalz, M., Bergmann, J., Handke, M., Mollmer, J., Lange, M., Roth, C., Moller, A., Staudt, R. and Krautscheid, H. (2012). An isomorphous series of cubic, copper-based triazolyl isophthalate MOFs: linker substitution and adsorption properties. Inorg Chem 51(14): 7579-7586.
  7. Groning, J. A., Roth, C., Kaschabek, S. R., Strater, N. and Schlomann, M. (2012). Recombinant expression of a unique chloromuconolactone dehalogenase ClcF from Rhodococcus opacus 1CP and identification of catalytically relevant residues by mutational analysis. Arch Biochem Biophys 526(1): 69-77.
  8. Dahms, S. O., Kuester, M., Streb, C., Roth, C., Strater, N. and Than, M. E. (2013). Localization and orientation of heavy-atom cluster compounds in protein crystals using molecular replacement. Acta Crystallogr D Biol Crystallogr 69(Pt 2): 284-297.
  9. MüMuller, M. Q., Roth, C., Strater, N. and Sinz, A. (2008). Expression and purification of the ligand-binding domain of peroxisome proliferator-activated receptor alpha (PPARalpha). Protein Expr Purif 62(2): 185-189.
已发表 protocol 1篇
Purification and Crystallization of Chloromuconolactone Dehalogenase ClcF from Rhodococcus opacus 1CP
红球菌属1CP中的氯代粘康酸内酯脱卤素酶CLcF的纯化和结晶化

The protocol describes the generation of variants of chloromuconolactone dehalogenase from Rhodococcus opacus (R. opacus) 1CP. ClcF is a multimeric protein, which catalyses the dechlorination of 5-chloromuconolactone to cis ...
参审 protocol 6篇
Preparation of Yeast tRNA Sample for NMR Spectroscopy
酵母tRNA样品的核磁共振制备
作者:Marjorie Catala, Alexandre Gato, Carine Tisné and Pierre Barraud日期:06/20/2020,浏览量:1833,Q&A: 0
Transfer RNAs (tRNAs) are heavily decorated with post-transcriptional modifications during their biosynthesis. To fulfil their functions within cells, tRNAs undergo a tightly controlled biogenesis process leading to the formation of mature tRNAs. In ...
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Immunoprecipitation of Cell Surface Proteins from Gram-negative Bacteria
革兰氏阴性菌细胞表面蛋白的免疫沉淀
作者:Carlos Eduardo Pouey Cunha, Jane Newcombe, Odir Antonio Dellagostin and Johnjoe McFadden日期:05/05/2017,浏览量:6990,Q&A: 0
The meningococcus (Neisseria meningitidis) remains an important threat to human health worldwide. This Gram-negative bacterium causes elevated disabilities and mortality in infected individuals. Despite several available vaccines, currently ...
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