评审
Alexandros C Kokotos
  • Post-Doc, Weill Cornell Medicine
研究方向
  • Cell Biology, Molecular Biology, Neuroscience
个人信息

教育背景

PhD, University of Edinburgh, 2017

实验室信息

Prof. Timothy Ryan's lab
https://sites.google.com/site/ryanlab1/Home

研究方向

Synaptic vesicle recycling
Endocytosis
Neurotransmission
Rab GTPases
Synaptic endosomes
Synaptic metabolism
GLUT4 trafficking

发表论文

https://www.ncbi.nlm.nih.gov/pubmed/?term=kokotos+ac
Mantzourani, C., Gkikas, D., Kokotos, A., Nummela, P., Theodoropoulou, M.A., Wu, K.-C., Fairlie, D.P., Politis, P.K., Ristimäki, A., and Kokotos, G. (2021). Synthesis of benzoxazole-based vorinostat analogs and their antiproliferative activity. Bioorg. Chem. 114, 105132.

Kokotou, M.G., Kokotos, A.C., Gkikas, D., Mountanea, O.G., Mantzourani, C., Almutairi, A., Lei, X., Ramanadham, S., Politis, P.K., and Kokotos, G. (2020). Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β-Cell Apoptosis. J. Med. Chem. 63, 12666–12681.

Kokotos, A.C., Harper, C.B., Marland, J.R.K., Smillie, K.J., Cousin, M.A., and Gordon, S.L. (2019). Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin-II levels. J. Neurochem 151, 28-37.

Kokotos, A.C., Peltier, J., Davenport, E.C., Trost, M., and Cousin, M.A. (2018). Activity dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11. Proceedings of the National Academy of Sciences, 201809189.

Peiris, H., Duffield, M.D., Fadista, J., Jessup, C.F., Kashmir, V., Genders, A.J., McGee, S.L., Martin, A.M., Saiedi, M., Morton, N., Carter, R., Cousin, M.A., Kokotos, A.C., Oskolkov, N., Volkov, P., Hough, T.A., Fisher, E.M., Tybulewicz, V.L., Busciglio, J., Coskun, P.E., Becker, A., Belichenko, P.V., Mobley, W.C., Ryan, M.T., Chan, J.Y., Laybutt, D.R., Coates, P.T., Yang, S., Ling, C., Groop, L., Pritchard, M.A., and Keating, D.J. (2016). A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to beta-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS genetics 12, e1006033.

Nicholson-Fish, J.C., Kokotos, A.C., Gillingwater, T.H., Smillie, K.J., and Cousin, M.A. (2015). VAMP4 Is an Essential Cargo Molecule for Activity-Dependent Bulk Endocytosis. Neuron 88, 973-984.

Kokotos, A.C., and Low, D.W. (2015). Myosin II and Dynamin Control Actin Rings to Mediate Fission during Activity-Dependent Bulk Endocytosis. The Journal of neuroscience 35, 8687-8688.

Kokotos, A.C., and Cousin, M.A. (2015). Synaptic vesicle generation from central nerve terminal endosomes. Traffic 16, 229-240.

Karachaliou, M., Amillis, S., Evangelinos, M., Kokotos, A.C., Yalelis, V., and Diallinas, G. (2013). The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals. Molecular microbiology 88, 301-317.