联合作者(
Clément Mazeaud INRS-Institut Armand-Frappier, Institut National de la Recherche Scientifique, Canada, Canada,
1 protocol

Wesley Freppel INRS-Institut Armand-Frappier, Institut National de la Recherche Scientifique, Canada, Canada,
1 protocol

Laurent Chatel-Chaix
  • Assistant professor, INRS-Institut Armand-Frappier, Institut National de la Recherche Scientifique, Canada
研究方向
  • Virologie moléculaire
  • 已发表 protocol 1

教育背景

Ph.D. of Biochemistry, University of Montréal, Canada, 2006

实验室信息

Chatel-Chaix Lab
http://www.inrs.ca/laurent-chatel-chaix

发表论文

  1. Mazeaud C*, Freppel W*, Chatel-Chaix L. The Multiples Fates of the Flavivirus RNA Genome during Pathogenesis. Frontiers in Genetics (2018) (Review) Accepted. (* Equal contributions) 
  2. Cortese M, Goellner S, Acosta EG, Neufeldt CJ, Oleksiuk O, Lampe M, Haselmann U, Funaya C, Schieber N, Ronchi P, Schorb M, Pruunsild P, Schwab Y, Chatel-Chaix L, Ruggieri A, Bartenschlager R. Ultrastructural Characterization of Zika Virus Replication Factories. Cell Reports (2017) 18(9):2113-2123. 
  3. Chatel-Chaix L. The Remodeling of the Cytoplasm by Dengue Virus. Journal of Bacteriology and Mycology (2016) 3(5):id1039 (Review). 
  4. Chatel-Chaix L*, Cortese M, Romero-Brey I, Bender S, Neufeldt CJ, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B, Ruggieri A, Bartenschlager R*. Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses. Cell Host & Microbe (2016) 20(3):342-56. (* Co-corresponding authors) 
  5. Tremblay N, Baril M, Chatel-Chaix L, Es-Saad S, Park AY, Koenekoop RK, Lamarre D. Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response. PLoS Pathogens (2016) 12(7):e1005772. 
  6. Scaturro P, Cortese M, Chatel-Chaix L, Fischl W, Bartenschlager R. Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins. PLoS Pathogens (2015) 11(11):e1005277. 
  7. Chatel-Chaix L*, Fischl W*, Scaturro P, Cortese M, Kallis S, Bartenschlager M, Fischer B, Bartenschlager R. A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication. Journal of Virology (2015) 89(14): 7170-86. (* Equal contributions) 
  8. Metz P, Chiramel A, Chatel-Chaix L, Alvisi G, Bankhead P, Mora-Rodríguez R, Long G, Hamacher-Brady A, Brady NR, Bartenschlager R. Dengue virus inhibition of autophagic flux and dependency of viral replication on proteasomal degradation of the autophagy receptor p62. Journal of Virology (2015) 89(14): 7170-7186. 
  9. Chatel-Chaix L, Bartenschlager R. A monocytic detour to replicate patient-derived hepatitis C virus in hepatoma cells and its use for phenotypic analyses. Hepatology (2015) 61(4): 1112-4. (Comment) 
  10. Chatel-Chaix L, Bartenschlager R. Dengue virus- and hepatitis C virus-induced replication and assembly compartments: the enemy inside-caught in the web. Journal of Virology (2014) 88(11): 5907-11. (Review) 
  11. Germain MA, Chatel-Chaix L, Gagné B, Bonneil É, Thibault P, Pradezynski F, de Chassey B, Meyniel-Schicklin L, Lotteau V, Baril M, Lamarre D. Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches. Molecular and Cellular Proteomics (2014) 13(1): 184-203. 
  12. Chatel-Chaix L, Germain MA, Motorina A, Bonneil É, Thibault P, Baril M, Lamarre D. A host YB-1 ribonucleoprotein complex is hijacked by hepatitis C virus for the control of NS3-dependent particle production. Journal of Virology (2013) 87(21): 11704-20. 
  13. Baril M, Es-Saad S, Chatel-Chaix L, Fink K, Pham T, Raymond VA, Audette K, Guenier AS, Duchaine J, Servant M, Bilodeau M, Cohen E, Grandvaux N, Lamarre D. Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. PLoS Pathogens (2013) 9(6): e1003416. 
  14. Chatel-Chaix L, Germain MA, Götte M, Lamarre D. Direct-acting and host-targeting HCV inhibitors: current and future directions. Current Opinion in Virology (2012) 2(5): 588-98. (Review) 
  15. Jouan L, Chatel-Chaix L, Melançon P, Rodrigue-Gervais IG, Raymond VA, Selliah S, Bilodeau M, Grandvaux N, Lamarre D. Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients. Journal of Hepatology (2012) 56(1): 70-7.
  16. Chatel-Chaix L, Melançon P, Racine MÈ, Baril M, Lamarre D. Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production. Journal of Virology (2011) 85(21): 11022-37. 
  17. Chatel-Chaix L*, Baril M*, Lamarre D. Pharmacology and mechanisms of action of antiviral drugs: Protease inhibitors. Advanced Therapy for Hepatitis C. (2011) 53-59. (Book Chapter) (* Equal contributions) 
  18. Chatel-Chaix L*, Baril M*, Lamarre D. Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel. Viruses. (2010) 2(8): 1752-65. (Review) (* Equal contributions) 
  19. Abrahamyan LG, Chatel-Chaix L, Ajamian L, Milev MP, Monette A, Clément JF, Song R, Lehmann M, DesGroseillers L, Laughrea M, Boccaccio G, Mouland AJ. Novel Staufen1 ribonucleoproteins prevent formation of stress granules but favour encapsidation of HIV-1 genomic RNA. Journal of Cell Science (2010) 123(3): 369-83. 
  20. Chatel-Chaix L, Boulay K, Mouland, AJ, DesGroseillers L. The host protein Staufen1 interacts with the pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus. Retrovirology (2008) 5, 41 
  21. Chatel-Chaix L, Abrahamyan L, Fréchina C, Mouland AJ, DesGroseillers L. The host protein Staufen1 participates in HIV-1 assembly in live cells by influencing pr55Gag multimerization. Journal of Virology (2007) 81, 6216-6230 
  22. Levesque K, Halvorsen M, Abrahamyan L, Chatel-Chaix L, Poupon V, Gordon H, DesGroseillers L, Gatignol A, Mouland AJ. Trafficking of HIV-1 RNA is mediated by heterogeneous nuclear ribonucleoprotein A2 expression and impacts on viral assembly. Traffic (2006) 7, 1177-1193 
  23. Dugré-Brisson S, Elvira G, Boulay K, Chatel-Chaix L, Mouland AJ, DesGroseillers L. Interaction of Staufen1 with the 5' end of mRNA facilitates translation of these RNAs. Nucleic Acids Research (2005) 33, 4797-4812. 
  24. Chatel-Chaix L, Clement JF, Martel C, Beriault V, Gatignol A, DesGroseillers L, Mouland AJ. Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles. Molecular and Cellular Biology (2004) 24, 2637-2648.
已发表 protocol 1篇
Production, Titration and Imaging of Zika Virus in Mammalian Cells
哺乳动物细胞中寨卡病毒的制备、滴度测定和成像

作者:Wesley Freppel, Clément Mazeaud and Laurent Chatel-Chaix日期:12/20/2018,浏览量:7641,Q&A: 0
Since the outbreak of Zika virus (ZIKV) in Latin America and the US in 2016, this flavivirus has emerged as a major threat for public health. Indeed, it is now clear that ZIKV is vertically transmitted from the infected mother to the fetus and this ...