联合作者(
Jinliang Huang Tsinghua University, China
2 protocols

Geng Wang
  • Principle Investigator, School of Life Sciences, Tsinghua University, China
研究方向
  • 生物化学
  • 已发表 protocol 2

教育背景

Ph.D., University of Iowa, USA, 2006

发表论文

· Zheng Q, Liu P, Gao G, Yuan J, Wang P, Huang J, Xie L, Lu X, Di F, Tong T, Chen J, Lu Z, Guan J, Wang G*. (2019) Mitochondrion-processed TERC regulates senescence without affecting telomerase activities. Protein Cell, doi: 10.1007/s13238-019-0612-5. [Epub ahead of print].
· Huang J, Liu P, Wang G*. (2018) Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2). J biol chem, 293, 19633-19644.
· Cheng Y, Liu P, Zheng Q, Gao G, Yuan J, Wang P, Huang J, Xie L, Lu X, Tong T, Chen J, Lu Z, Guan J, Wang G*. (2018) Mitochondrial Trafficking and Processing of Telomerase RNA TERC. Cell Reports, 24(10):2589-2595.
· Liu P, Huang J, Zheng Q, Xie L, Lu X, Jin J, Wang G* (2017) Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2. Protein & Cell 8(1): 735-749.
· Wang G, Shimada E, Nili M, Koehler CM, Teitell MA (2015) Mitochondria-targeted RNA import. Methods Mol Biol. 1264:107-116.
· Wang G, Shimada E, Koehler CM, Teitell MA (2012) PNPASE and RNA trafficking into mitochondria. Biochimi Biophys Acta. 1819(9-10):998-1007.
· Wang G, Shimada E, Zhang J, Hong JS, Smith GM, Teitell MA, Koehler CM (2012) Correcting human mitochondrial mutations with targeted RNA import. Proc Natl Acad Sci U S A. 109(13):4840-4845.
· von Ameln S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, Nürnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, Nürnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A, Kubisch C (2012) A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss. Am J Hum Genet. 91(5):919-927.
· Wang G, Chen HW, Oktay Y, Zhang J, Allen EL, Smith GM, Fan KC, Hong JS, French SW, McCaffery JM, Lightowlers RN, Morse HC 3rd, Koehler CM, Teitell MA (2010) PNPASE regulates RNA import into mitochondria. Cell. 142(3):456-467.
· Wang G, Deschenes RJ (2006) Plasma membrane localization of Ras requires class C Vps proteins and functional mitochondria in Saccharomyces cerevisiae. Mol Cell Biol, 26:3243-3255.

(* means corresponding author)
已发表 protocol 2篇
Organelle-associated rRNA Degradation
附着在细胞器上的rRNA降解

作者:Jinliang Huang and Geng Wang日期:06/05/2019,浏览量:3446,Q&A: 0
Cytosolic rRNAs are highly dynamic and can be degraded under conditions such as apoptosis, starvation and magnesium depletion. The degradation is also related to their specific localization, as fractions of cytosolic ribosomes are localized on the ...
Improved Mammalian Mitochondrial RNA Isolation
一种改进的哺乳动物线粒体RNA分离方法

作者:Jinliang Huang and Geng Wang日期:06/05/2019,浏览量:4732,Q&A: 0
Mitochondria have two sets of RNAs. One is encoded in mitochondrial genome, and the other that consists of imported RNAs within mitochondria and cytosolic RNAs associated with mitochondrial outer membrane is encoded in the nucleus. These ...