联合作者(
Feng-Jung Chen Fudan University
2 protocols

Peng Li 2 protocols

Jia Wang School of Pharmaceutical Science, Tsinghua University
2 protocols

Boon Tin Chua
  • Visiting Scientist, Institute of Metabolism and Integrated Biology, Fudan University
研究方向
  • 细胞生物学
  • 已发表 protocol 2

教育背景

Ph.D. in Molecular and Cell Biology, National University of Singapore, Singapore, 2004

发表论文

• Li Q, Zhao Q, Zhang J, Zhou L, Zhang W, Chua BT, Chen Y, Xu L and Li P (2019) The protein phosphatase I complex is a direct target of AKT linking insulin signaling to hepatic glycogen deposition. Cell Reports (revision)

• Lv X, Liu J, Qin Y, Liu Y, Jin M, Dai J, Chua BT, Yang H and Li P (2019). Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids 1864(2), 113-127

• Wang J, Yan C, Xu C, Chua BT, Li P and Chen FJ (2018). Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids. Journal of Biological Chemistry 293(50), 19330-19343

• Jakhar R, Luijten MNH, Wong AXF, Cheng B, Guo K, Neo SP, Au B, Kulkarni M, Lim KJ, Maimaiti J, Chong HC, Lim EH, Tan TBK, Ong KW, Sim Y, Wong JSL, Khoo JBK, Ho JTS, Chua BT, Sinha I, Wang X, Connolly JE, Gunaratne J and Crasta KC (2018). Autophagy governs protumorigenic effects of mitotic slippage-induced senescence. Molecular Cancer Research 16(11), 1625-1640

• Tan SW, Chong FT, Leong HS, Toh D, Lau P, Kwang XL, Zhang XQ, Sundaram GM, Tan GS, Chang MM, Chua BT, Lim WT, Tan EH, Ang MK, Lim T, Sampath P, Chowbay B, Skanderup AJ, DasGupta R and Iyer NG (2017). Long non-coding EGFR-AS1 mediates Epidermal Growth Factor Receptor addiction and modulates treatment response in squamous cell carcinoma. Nature Medicine 23, 1167-1175

• Lee MC, Shei W, Chan A, Chua BT, Goh SR, Chong YF, Hilmy M, Nongpiur M, Baskaran M, Khor CC, Aung T, Hunziker W, and Vithana E (2017). Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function. Human Molecular Genetics 26(20), 4011-4027

• Duan Y, Wong W, Chua SC, Wee HL, Lim SG, Chua BT and Ho HK (2016).
 Overexpression of Tyro3 and its implications on hepatocellular carcinoma progression. International Journal of Oncology 48(1):358-66

• Tan DSW, Haaland B, Gan JM, Tham SC, Sinha I, Tan EH, Lim KH, Takano A, Krisna S, Myint Thu MM, Liew HP, Ullrich A, Lim WT and Chua BT (2014). Bosutinib inhibits migration and invasion via ack1 in kras mutant non-small cell lung cancer. Molecular Cancer 13:13

• Ho HK, Yeo HL, Kang TS and Chua BT (2014). Current strategies for inhibiting FGFR activities in clinical applications: opportunities, challenges and toxicological considerations. Drug Discovery Today 19(1):51-62

• Ho HK*, Chua BT*, Wong W, Lim KS, Teo V, Ong HT, Chen X, Zhang W, Hui KM, Go ML and Ullrich A (2014). Benzylidene-indolinones are Effective as Multi-targeted Kinase Inhibitor Therapeutics Against Hepatocellular Carcinoma. Molecular Oncology 8(7):1266–1277 (* co-first authors)

• Ho HK, Németh G, Ng YR, Pang E, Szántai-Kis C, Zsákai L, Breza N, Greff Z, Horváth Z, Pató J, Szabadkai I, Szokol B, Baska F, Orfi L, Ullrich A, Kéri G and Chua BT (2013). Developing FGFR4 Inhibitors as Potential Anti-Cancer Agents via In Silico Design, Supported By In Vitro And Cell-Based Testing. Current Medicinal Chemistry 20:1203-17

• Poh WJ, Wong W, Ong HM, Aung MO, Lim SG, Chua BT and Ho HK (2012). Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma. Molecular Cancer 11:14

• Chua BT, Lim SJ, Tham SC, Poh WJ and Ullrich A (2010). Somatic mutation of ACK1 at ubiquitin-association domain enhances mitogenic signaling through EGFR regulation in kidney carcinoma. Molecular Oncology 4, 323-34

• Sukumaran SK, Fu NY, Chua BT, Wan KF, Lee SS and Yu VC (2010). A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis. Molecular Cell 37, 768-83

• Chua BT, Gallego-Ortega D, De Molina AR, Ullrich A, Lacal JC and Downward J (2009). Regulation of Akt(ser473) phosphorylation by Choline Kinase in breast carcinoma cells. Molecular Cancer 8:131

• Volbracht C, Chua BT, Ng CP, Bahr BA, Hong W, Li P (2005). The critical role of calpain versus caspase activation in excitotoxic injury induced by nitric oxide. J Neurochemistry 93(5), 1280-92. Erratum in: Journal of Neurochemistry 94(5), 1471.

• Chua BT, Volbracht C, Tan KO, Li R, Yu VC, Li P (2003). Mitochondrial translocation of cofilin is an early step in apoptosis induction. Nature Cell Biology 5(12), 1083-9.

• Chua BT, Guo K, Li P. (2000). Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases. Journal of Biological Chemistry 275(7), 5131-5.
已发表 protocol 2篇
Lipid-exchange Rate Assay for Lipid Droplet Fusion in Live Cells
活体细胞中脂滴融合的脂类交换速率检测

作者:Jia Wang, Boon Tin Chua, Peng Li and Feng-Jung Chen日期:07/20/2019,浏览量:3832,Q&A: 0
Lipid droplets (LDs) are central organelles in maintaining lipid homeostasis. Defective LD growth often results in the development of metabolic disorders. LD fusion and growth mediated by cell death–inducing DNA fragmentation factor alpha ...