联合作者(
Binks Wattenberg Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond
1 protocol

Christopher D. Oltorik Biochemistry and Molecular Biology, Virginia Commonwealth University, 2018-
1 protocol

John Suemitsu 1 protocol

Deanna L. Davis 1 protocol

Muthukumar Kannan
  • Faculty, UNMC, Omaha,
研究方向
  • 生物化学
  • 已发表 protocol 1

教育背景

PhD, Bharathidasan University, India, 2011

发表论文

• Gowsalya, R., Ravi, C., Kannan, M. and Nachiappan, V. (2019). FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae. FEMS Yeast Res 19(3).
• Davis, D., Kannan, M. and Wattenberg, B. (2018). Orm/ORMDL proteins: Gate guardians and master regulators. Adv Biol Regul 70: 3-18.
• Friedman, J. R., Kannan, M., Toulmay, A., Jan, C. H., Weissman, J. S., Prinz, W. A. and Nunnari, J. (2018). Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER. Dev Cell 44(2): 261-270 e266.
• Kannan, M., Lahiri, S., Liu, L. K., Choudhary, V. and Prinz, W. A. (2017). Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER. J Lipid Res 58(3): 553-562.
• Kannan, M., Sivaprakasam, C., Prinz, W. A. and Nachiappan, V. (2016). Endoplasmic reticulum stress affects the transport of phosphatidylethanolamine from mitochondria to the endoplasmic reticulum in S.cerevisiae. Biochim Biophys Acta 1861(12 Pt A): 1959-1967.
• Kannan, M., Riekhof, W. R. and Voelker, D. R. (2015). Transport of phosphatidylserine from the endoplasmic reticulum to the site of phosphatidylserine decarboxylase2 in yeast. Traffic 16(2): 123-134.
• Muthukumar, K. and Nachiappan, V. (2013). Phosphatidylethanolamine from phosphatidylserine decarboxylase2 is essential for autophagy under cadmium stress in Saccharomyces cerevisiae. Cell Biochem Biophys 67(3): 1353-1363.
• Vijayaraj, P., Muthukumar, K., Sabarirajan, J. and Nachiappan, V. (2013). Antihyperlipidemic activity of Cassia auriculata flowers in triton WR 1339 induced hyperlipidemic rats. Exp Toxicol Pathol 65(1-2): 135-141.
• Muthukumar, K., Rajakumar, S., Sarkar, M. N. and Nachiappan, V. (2011). Glutathione peroxidase3 of Saccharomyces cerevisiae protects phospholipids during cadmium-induced oxidative stress. Antonie Van Leeuwenhoek 99(4): 761-771.
• Muthukumar, K. and Nachiappan, V. (2010). Cadmium-induced oxidative stress in Saccharomyces cerevisiae. Indian J Biochem Biophys 47(6): 383-387.
• Vijayaraj, P. S., Muthukumar, K., Sabarirajan, J. and Nachiappan, V. (2011). Evaluation of antihyperlipidemic activity of ethanolic extract of Cassia auriculata flowers. Indian J Biochem Biophys 48(1): 54-58.
已发表 protocol 1篇
Preparation of HeLa Total Membranes and Assay of Lipid-inhibition of Serine Palmitoyltransferase Activity
HeLa全膜的制备及其对丝氨酸-棕榈酰转移酶活性的抑制作用

作者:Muthukumar Kannan, Deanna L. Davis, John Suemitsu, Christopher D. Oltorik and Binks Wattenberg日期:06/20/2020,浏览量:1891,Q&A: 0
Serine palmitoyltranferase (SPT) is a pyridoxal 5′ phosphate (PLP)-dependent enzyme that catalyzes the first and rate-limiting step of de novo synthesis of sphingolipids. SPT activity is homeostatically regulated in response to increased ...