联合作者(
Susanna Rosi Brain and Spinal Injury Center, University of California San Francisco, USA
1 protocol

Timothy Jopson Brain and Spinal Injury Center, University of California San Francisco, USA
1 protocol

Karen Krukowski Brain and Spinal Injury Center, University of California San Francisco, USA
1 protocol
联合评审(
Adler R. Dillman Nematology, UC Riverside, USA
13 protocols

Akira Karasawa New York Structural Biology Center
8 protocols

Amey Redkar Department of Genetics, University of Cordoba
22 protocols

Beatriz Castro Purdue University
3 protocols

编委
Xi Feng
  • Research scientist, University of California, San Francisco
研究方向
  • 神经科学
  • Cognitive Neuroscience, Brain Tumor Mircroenvironment
  • 已发表 protocol 1

教育背景

PhD, Chinese Academy of Sciences

实验室信息

Rosi Lab at UCSF

发表论文

1. Feng, X., Liu, S., Chen, D., Rosi, S. and Gupta, N. (2018) Rescue of cognitive function following fractionated brain irradiation in a novel preclinical glioma model. eLife
2. *Krukowski, K., *Feng, X., Paladini, MS., Chou, A., Sacramento, K., Gure, K., Riparip, LK., Jones, T., Campbell-Beachler, M., Nelson, G. and Rosi, S. (2018) Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. Sci. Rep. * co-first authors
3. Feng, X., Krukowski, K., Jopson, T. and Rosi S. (2017) Delayed-matching-to-place task in a dry maze to measure spatial working memory in mice. Bio Protoc.
4. Feng, X. and Rosi, S. (2017) Targeting colony stimulating factor 1 receptor to prevent cognitive deficits induced by fractionated whole-brain irradiation. Neural Regen Res.
5. Feng, X., Jopson, T., Paladini, M.S., Liu, S., West, B., Gupta, N. and Rosi, S. (2016) CSF-1R blockade prevents fractionated cranial irradiation induced memory loss. Journal of Neuroinflammation.
6. Feng, X., Szulzewsky, F., Yerevanian A., Chen Z., Heinzmann D., Rasmussen, D.R, Alvarez-Garcia, V., Kim, Y., Wang, B., Tamagno, I., Zhou, H., Li, X., Kettenmann, H., Ransohoff, R.M. and Hambardzumyan, D. (2015) Loss of CX3CR1 increases accumulation of inflammatory monocytes and promote gliomagenesis. Oncotarget.
7. Feng, X., Liu, X., Zhang, W., and Xiao, W. (2011) P53 Directly Suppresses BNIP3 Expression to Protect Against Hypoxia-induced Cell Death. EMBO Journal.
8. Krukowski, K., Chou, A., Feng, X., Tiret, B., Paladini, M.S., Riparip, L.K., Chaumeil, M.M., Lemere, C and Rosi, S. (2018) Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits. Int. J. Mol. Sci.
9. Guglielmetti, C., Chou, A., Krukowski, K., Najac, C., Feng, X.,Riparip, L.R., Rosi, S., Chaumeil M.M., (2017) In vivo metabolic imaging of Traumatic Brain Injury. Scientific Reports.
10. Chen, Z., Feng, X., Herting, C.J., Alvares Garcia, V., Nie, K., Pong, W.W., Rasmussen, R., Dwivedi, B., Seby, S., Wolf, S.A., Gutmann, D., and Hambardzumyan, D. (2017) Identity and gene profile of tumor-associated macrophages in glioblastoma. Cancer Research
11. Szulzewsky, F., Pelz, A., Feng, X., Synowitz, M., Markovic, D., Langmann, T., Holtman, I.R., Wang, X., Eggen, B.J.L., Boddeke, H., Hambardzumyan, D., Wolf, S.A. and Ketternmann, H. (2015) Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and higly express GPNMB and SPP1. PLoS One.
12. Pitter, K.L.,Tamagno, I., Feng, X., Ghosal, K., Amankulor, N., Holland, E.C., and Hambardzumyan, D. (2014) The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions. Glia.
13. Hu, B., Zhang, W., Feng, X., Ji, W., Xie, X., and Xiao, W. (2014) Zebrafish eaf1 Suppresses Foxo3b Expression to Modulate Transcriptional Activity of Gata1 and Spi1 in Primitive Hematopoiesis. Developmental Biology.
14. Pong, W., Walker, J., Wylie, T., Magrini, V., Luo, J., Emnett, R., Choi, J., Cooper, M., Griffith, M.,Griffith, O., Rubin, J., Fuller, G., Piwnica-Worms, D., Feng, X., Hanbardzumyan, D., DiPersio, J., Mardis, J.,and Gutmann, D. (2013) F11R is a Novel Monocyte Prognostic Biomarker for Malignant Glioma. PLOS ONE.
15. Li, M., He, Y., Feng, X., and Huang, J. (2012) Genome-wide stidies of the transcriptional regulation by p53. Biochimica et Biophysica Acta.
16. Wan, X.,Hu, B., Liu, J.,Feng, X., and Xiao, W., (2011) The Essential Role of Mll in Zebrafish Hematopoiesis. Journal of Biological Chemistry.
17. Zhou, J., Feng, X., Ban, B., Liu, J., Wang, Z., and Xiao, W. (2009) The Elongation Factor Ell (Eleven-nineteen Lysine-Rich Leukemia) Acts as a Transcription Factor for Direct Thrombospondin-1 Regulation. Journal of Biological Chemistry.
已发表 protocol 1篇
Delayed-matching-to-place Task in a Dry Maze to Measure Spatial Working Memory in Mice
采用日间迷宫中延迟位置匹配任务来衡量小鼠的空间工作记忆

作者:Xi Feng, Karen Krukowski, Timothy Jopson and Susanna Rosi日期:07/05/2017,浏览量:6859,Q&A: 0
The delayed-matching-to-place (DMP) dry maze test is a variant of DMP water maze (Steele and Morris, 1999; Faizi et al., 2012) which measures spatial working/episodic-like learning and memory that depends on both hippocampal and cortical ...
参审 protocol 10篇
Assessing Prepulse Inhibition of Startle in Mice
评估小鼠惊吓的前脉冲抑制
作者:Christina Ioannidou, Giovanni Marsicano and Arnau Busquets-Garcia日期:04/05/2018,浏览量:8893,Q&A: 0
Animal models are an important tool for studying neuropsychiatric disorders. However, a major challenge for researchers working with laboratory rodents is trying to reproduce ‘core’ symptoms of complex human disorders such as schizophrenia. Despite ...
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In vivo Leukemogenesis Model Using Retrovirus Transduction
采用逆转录病毒转导的体内白血病生成模型
作者:Hiroshi Okuda and Akihiko Yokoyama日期:12/05/2017,浏览量:6789,Q&A: 0
Various genetic alterations such as chromosomal translocation cause leukemia. For examples, gene rearrangements of the mixed-lineage leukemia (MLL) gene generate MLL fusion genes, whose products are potent oncogenic drivers in ...
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主审 protocol 25篇
Identification of Socially-activated Neurons
社交激活神经元的识别
作者:Mary L. Phillips and Lucas Pozzo-Miller日期:09/05/2020,浏览量:3058,Q&A: 0
Determining the neuronal circuitry responsible for specific behaviors is a major focus in the field of neurobiology. Activity-dependent immediate early genes (IEGs), transcribed and translated shortly after neurons discharge action potentials, have ...
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Single-cell qPCR Assay with Massively Parallel Microfluidic System
大规模平行微流控系统用于单细胞qPCR检测
作者:Marta Prieto-Vila, Takahiro Ochiya and Yusuke Yamamoto日期:03/20/2020,浏览量:2549,Q&A: 0
The single-cell transcriptome is the set of messenger RNA molecules expressed in one cell. It is extremely variable and changes according to external, physical and biochemical conditions. Due to sensitivity shortages, most of genetic studies use ...
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