Education

Ph.D., Kyoto University Graduate School of Medicine, 2006

Current position

Dana-Farber Cancer Institute, Harvard Medical School (2015-present)

Publications

1. Okahashi, N., Kohno, S., Kitajima, S., Matsuda, F., Takahashi, C. and Shimizu, H. (2015). Metabolic characterization of cultured mammalian cells by mass balance analysis, tracer labeling experiments and computer-aided simulations. J Biosci Bioeng 120(6): 725-731.
   
2. Kitajima, S., Kohno, S., Kondoh, A., Sasaki, N., Nishimoto, Y., Li, F., Abdallah Mohammed, M. S., Muranaka, H., Nagatani, N., Suzuki, M., Kido, Y. and Takahashi, C. (2015). Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts. Stem Cells 33(5): 1657-1669.
   
3. Shamma, A., Suzuki, M., Hayashi, N., Kobayashi, M., Sasaki, N., Nishiuchi, T., Doki, Y., Okamoto, T., Kohno, S., Muranaka, H., Kitajima, S., Yamamoto, K. and Takahashi, C. (2013). ATM mediates pRB function to control DNMT1 protein stability and DNA methylation. Mol Cell Biol 33(16): 3113-3124.
   
4. Takahashi, C., Sasaki, N. and Kitajima, S. (2012). Twists in views on RB functions in cellular signaling, metabolism and stem cells. Cancer Sci 103(7): 1182-1188.
   
5. Taura, M., Suico, M. A., Koyama, K., Komatsu, K., Miyakita, R., Matsumoto, C., Kudo, E., Kariya, R., Goto, H., Kitajima, S., Takahashi, C., Shuto, T., Nakao, M., Okada, S. and Kai, H. (2012). Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells. Mol Cell Biol 32(8): 1581-1590.
   
6. Kitajima, S., Miki, T., Takegami, Y., Kido, Y., Noda, M., Hara, E., Shamma, A. and Takahashi, C. (2011). Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling. Oncogene 30(6): 737-750.
   
7. Miki, T., Shamma, A., Kitajima, S., Takegami, Y., Noda, M., Nakashima, Y., Watanabe, K. and Takahashi, C. (2010). The ss1-integrin-dependent function of RECK in physiologic and tumor angiogenesis. Mol Cancer Res 8(5): 665-676.
   
8. Shamma, A., Takegami, Y., Miki, T., Kitajima, S., Noda, M., Obara, T., Okamoto, T. and Takahashi, C. (2009). Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation. Cancer Cell 15(4): 255-269.
   
9. Muraguchi, T., Takegami, Y., Ohtsuka, T., Kitajima, S., Chandana, E. P., Omura, A., Miki, T., Takahashi, R., Matsumoto, N., Ludwig, A., Noda, M. and Takahashi, C. (2007). RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity. Nat Neurosci 10(7): 838-845.