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Thomas C. Mettenleiter
  • Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Germany
研究方向
  • Microbiology
个人信息

Education

Habilitation, Eberhard-Karls-Universität Tübingen, Germany, 2000

Current position

President, Friedrich-Loeffler-Institut, Friedrich-Loeffler-Institut, Germany

Publications (since 2010)

  1. Vallbracht, M., Rehwaldt, S., Klupp, B. G., Mettenleiter, T. C. and Fuchs, W. (2017). Functional relevance of the N-terminal domain of pseudorabies virus envelope glycoprotein H and its interaction with glycoprotein L. J Virol.
  2. Pohlmann, A., Starick, E., Harder, T., Hoper, D., Globig, A., Staubach, C., Dietze, K., Grund, C., Strebelow, G., Ulrich, R. G., Schinkothe, J., Teifke, J. P., Conraths, F. J., Mettenleiter, T. C. and Beer, M. (2017). Outbreaks among Wild Birds and Domestic Poultry Caused by Reassorted Influenza A(H5N8) Clade 2.3.4.4 Viruses, Germany, 2016. Emerg Infect Dis 23(4).
  3. Abdelwhab, E. M., Veits, J. and Mettenleiter, T. C. (2017). Biological fitness and natural selection of amantadine resistant variants of avian influenza H5N1 viruses. Virus Res 228: 109-113.
  4. Abdelwhab, E. M., Veits, J., Ulrich, R., Kasbohm, E., Teifke, J. P. and Mettenleiter, T. C. (2016). Composition of the Hemagglutinin Polybasic Proteolytic Cleavage Motif Mediates Variable Virulence of H7N7 Avian Influenza Viruses. Sci Rep 6: 39505.
  5. Hellberg, T., Passvogel, L., Schulz, K. S., Klupp, B. G. and Mettenleiter, T. C. (2016). Nuclear Egress of Herpesviruses: The Prototypic Vesicular Nucleocytoplasmic Transport. Adv Virus Res 94: 81-140.
  6. Mettenleiter, T. C. (2016). Vesicular Nucleo-Cytoplasmic Transport-Herpesviruses as Pioneers in Cell Biology. Viruses 8(10).
  7. Hanke, D., Freuling, C. M., Fischer, S., Hueffer, K., Hundertmark, K., Nadin-Davis, S., Marston, D., Fooks, A. R., Botner, A., Mettenleiter, T. C., Beer, M., Rasmussen, T. B., Muller, T. F. and Hoper, D. (2016). Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland. PLoS Negl Trop Dis 10(7): e0004779.
  8. Abdelwhab, E. M., Veits, J., Tauscher, K., Ziller, M., Grund, C., Hassan, M. K., Shaheen, M., Harder, T. C., Teifke, J., Stech, J. and Mettenleiter, T. C. (2016). Progressive glycosylation of the haemagglutinin of avian influenza H5N1 modulates virus replication, virulence and chicken-to-chicken transmission without significant impact on antigenic drift. J Gen Virol 97(12): 3193-3204.
  9. Zuhlsdorf, M., Werten, S., Klupp, B. G., Palm, G. J., Mettenleiter, T. C. and Hinrichs, W. (2016). Correction: Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease. PLoS Pathog 12(3): e1005506.
  10. Mettenleiter, T. C. (2016). Breaching the Barrier-The Nuclear Envelope in Virus Infection. J Mol Biol 428(10 Pt A): 1949-1961.
  11. Harder, T. C., Buda, S., Hengel, H., Beer, M. and Mettenleiter, T. C. (2016). Poultry food products--a source of avian influenza virus transmission to humans? Clin Microbiol Infect 22(2): 141-146.
  12. Abdelwhab el, S. M., Veits, J., Breithaupt, A., Gohrbandt, S., Ziller, M., Teifke, J. P., Stech, J. and Mettenleiter, T. C. (2016). Prevalence of the C-terminal truncations of NS1 in avian influenza A viruses and effect on virulence and replication of a highly pathogenic H7N1 virus in chickens. Virulence 7(5): 546-557.
  13. Hagen, C., Dent, K. C., Zeev-Ben-Mordehai, T., Grange, M., Bosse, J. B., Whittle, C., Klupp, B. G., Siebert, C. A., Vasishtan, D., Bauerlein, F. J., Cheleski, J., Werner, S., Guttmann, P., Rehbein, S., Henzler, K., Demmerle, J., Adler, B., Koszinowski, U., Schermelleh, L., Schneider, G., Enquist, L. W., Plitzko, J. M., Mettenleiter, T. C. and Grunewald, K. (2015). Structural Basis of Vesicle Formation at the Inner Nuclear Membrane. Cell 163(7): 1692-1701.
  14. Hoper, D., Freuling, C. M., Muller, T., Hanke, D., von Messling, V., Duchow, K., Beer, M. and Mettenleiter, T. C. (2015). High definition viral vaccine strain identity and stability testing using full-genome population data--The next generation of vaccine quality control. Vaccine 33(43): 5829-5837.
  15. Abdelwhab el, S. M., Veits, J., Tauscher, K., Ziller, M., Teifke, J. P., Stech, J. and Mettenleiter, T. C. (2015). A Unique Multibasic Proteolytic Cleavage Site and Three Mutations in the HA2 Domain Confer High Virulence of H7N1 Avian Influenza Virus in Chickens. J Virol 90(1): 400-411.
  16. Zuhlsdorf, M., Werten, S., Klupp, B. G., Palm, G. J., Mettenleiter, T. C. and Hinrichs, W. (2015). Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease. PLoS Pathog 11(7): e1005045.
  17. Schulz, K. S., Klupp, B. G., Granzow, H., Passvogel, L. and Mettenleiter, T. C. (2015). Herpesvirus nuclear egress: Pseudorabies Virus can simultaneously induce nuclear envelope breakdown and exit the nucleus via the envelopment-deenvelopment-pathway. Virus Res 209: 76-86.
  18. Klingbeil, K., Lange, E., Blohm, U., Teifke, J. P., Mettenleiter, T. C. and Fuchs, W. (2015). Protection of pigs against pandemic swine origin H1N1 influenza A virus infection by hemagglutinin- or neuraminidase-expressing attenuated pseudorabies virus recombinants. Virus Res 199: 20-30.
  19. Henning, A. K., Albrecht, D., Riedel, K., Mettenleiter, T. C. and Karger, A. (2015). An alternative method for serum protein depletion/enrichment by precipitation at mildly acidic pH values and low ionic strength. Proteomics 15(11): 1935-1940.
  20. Bohm, S. W., Backovic, M., Klupp, B. G., Rey, F. A., Mettenleiter, T. C. and Fuchs, W. (2015). Functional Characterization of Glycoprotein H Chimeras Composed of Conserved Domains of the Pseudorabies Virus and Herpes Simplex Virus 1 Homologs. J Virol 90(1): 421-432.
  21. Zeev-Ben-Mordehai, T., Weberruss, M., Lorenz, M., Cheleski, J., Hellberg, T., Whittle, C., El Omari, K., Vasishtan, D., Dent, K. C., Harlos, K., Franzke, K., Hagen, C., Klupp, B. G., Antonin, W., Mettenleiter, T. C. and Grunewald, K. (2015). Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling. Cell Rep 13(12): 2645-2652.
  22. Passvogel, L., Klupp, B. G., Granzow, H., Fuchs, W. and Mettenleiter, T. C. (2015). Functional characterization of nuclear trafficking signals in pseudorabies virus pUL31. J Virol 89(4): 2002-2012.
  23. Bohm, S. W., Backovic, M., Klupp, B. G., Rey, F. A., Mettenleiter, T. C. and Fuchs, W. (2015). A replication defect of pseudorabies virus induced by targeted alpha-helix distortion in the syntaxin-like bundle of glycoprotein H (V275P) is corrected by an adjacent compensatory mutation (V271A). J Gen Virol 96(8): 2349-2354.
  24. Schroter, C., Vallbracht, M., Altenschmidt, J., Kargoll, S., Fuchs, W., Klupp, B. G. and Mettenleiter, T. C. (2015). Mutations in Pseudorabies Virus Glycoproteins gB, gD, and gH Functionally Compensate for the Absence of gL. J Virol 90(5): 2264-2272.
  25. Bohm, S. W., Eckroth, E., Backovic, M., Klupp, B. G., Rey, F. A., Mettenleiter, T. C. and Fuchs, W. (2015). Structure-based functional analyses of domains II and III of pseudorabies virus glycoprotein H. J Virol 89(2): 1364-1376.
  26. Lorenz, M., Vollmer, B., Unsay, J. D., Klupp, B. G., Garcia-Saez, A. J., Mettenleiter, T. C. and Antonin, W. (2015). A single herpesvirus protein can mediate vesicle formation in the nuclear envelope. J Biol Chem 290(11): 6962-6974.
  27. Mohl, B. S., Schroter, C., Klupp, B. G., Fuchs, W., Mettenleiter, T. C., Jardetzky, T. S. and Longnecker, R. (2015). Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function. J Virol 90(5): 2285-2293.
  28. Mahjoub, N., Dhorne-Pollet, S., Fuchs, W., Endale Ahanda, M. L., Lange, E., Klupp, B., Arya, A., Loveland, J. E., Lefevre, F., Mettenleiter, T. C. and Giuffra, E. (2015). A 2.5-kilobase deletion containing a cluster of nine microRNAs in the latency-associated-transcript locus of the pseudorabies virus affects the host response of porcine trigeminal ganglia during established latency. J Virol 89(1): 428-442.
  29. Schroter, C., Klupp, B. G., Fuchs, W., Gerhard, M., Backovic, M., Rey, F. A. and Mettenleiter, T. C. (2014). The highly conserved proline at position 438 in pseudorabies virus gH is important for regulation of membrane fusion. J Virol 88(22): 13064-13072.
  30. Wernike, K., Beer, M., Freuling, C. M., Klupp, B., Mettenleiter, T. C., Muller, T. and Hoffmann, B. (2014). Molecular double-check strategy for the identification and characterization of Suid herpesvirus 1. J Virol Methods 209: 110-115.
  31. Passvogel, L., Janke, U., Klupp, B. G., Granzow, H. and Mettenleiter, T. C. (2014). Identification of conserved amino acids in pUL34 which are critical for function of the pseudorabies virus nuclear egress complex. J Virol 88(11): 6224-6231.
  32. Schulz, K. S., Liu, X., Klupp, B. G., Granzow, H., Cohen, J. I. and Mettenleiter, T. C. (2014). Pseudorabies virus pUL46 induces activation of ERK1/2 and regulates herpesvirus-induced nuclear envelope breakdown. J Virol 88(11): 6003-6011.
  33. Klingbeil, K., Lange, E., Teifke, J. P., Mettenleiter, T. C. and Fuchs, W. (2014). Immunization of pigs with an attenuated pseudorabies virus recombinant expressing the haemagglutinin of pandemic swine origin H1N1 influenza A virus. J Gen Virol 95(Pt 4): 948-959.
  34. Mettenleiter, T. C., Muller, F., Granzow, H. and Klupp, B. G. (2013). The way out: what we know and do not know about herpesvirus nuclear egress. Cell Microbiol 15(2): 170-178.
  35. Passvogel, L., Trube, P., Schuster, F., Klupp, B. G. and Mettenleiter, T. C. (2013). Mapping of sequences in Pseudorabies virus pUL34 that are required for formation and function of the nuclear egress complex. J Virol 87(8): 4475-4485.
  36. Schulz, K. S., Klupp, B. G., Granzow, H. and Mettenleiter, T. C. (2013). Glycoproteins gB and gH are required for syncytium formation but not for herpesvirus-induced nuclear envelope breakdown. J Virol 87(17): 9733-9741.
  37. Steglich, C., Grund, C., Ramp, K., Breithaupt, A., Hoper, D., Keil, G., Veits, J., Ziller, M., Granzow, H., Mettenleiter, T. C. and Romer-Oberdorfer, A. (2013). Chimeric newcastle disease virus protects chickens against avian influenza in the presence of maternally derived NDV immunity. PLoS One 8(9): e72530.
  38. Schuster, F., Klupp, B. G., Granzow, H. and Mettenleiter, T. C. (2012). Structural determinants for nuclear envelope localization and function of pseudorabies virus pUL34. J Virol 86(4): 2079-2088.
  39. Maresch, C., Lange, E., Teifke, J. P., Fuchs, W., Klupp, B., Muller, T., Mettenleiter, T. C. and Vahlenkamp, T. W. (2012). Oral immunization of wild boar and domestic pigs with attenuated live vaccine protects against Pseudorabies virus infection. Vet Microbiol 161(1-2): 20-25.
  40. Grimm, K. S., Klupp, B. G., Granzow, H., Muller, F. M., Fuchs, W. and Mettenleiter, T. C. (2012). Analysis of viral and cellular factors influencing herpesvirus-induced nuclear envelope breakdown. J Virol 86(12): 6512-6521.
  41. Fuchs, W., Backovic, M., Klupp, B. G., Rey, F. A. and Mettenleiter, T. C. (2012). Structure-based mutational analysis of the highly conserved domain IV of glycoprotein H of pseudorabies virus. J Virol 86(15): 8002-8013.
  42. Fuchs, W., Granzow, H., Veits, J. and Mettenleiter, T. C. (2012). Identification and functional analysis of the small membrane-associated protein pUL11 of avian infectious laryngotracheitis virus. Virus Res 163(2): 599-608.
  43. Hagen, C., Guttmann, P., Klupp, B., Werner, S., Rehbein, S., Mettenleiter, T. C., Schneider, G. and Grunewald, K. (2012). Correlative VIS-fluorescence and soft X-ray cryo-microscopy/tomography of adherent cells. J Struct Biol 177(2): 193-201.
  44. Hafezi, W., Lorentzen, E. U., Eing, B. R., Muller, M., King, N. J., Klupp, B., Mettenleiter, T. C. and Kuhn, J. E. (2012). Entry of herpes simplex virus type 1 (HSV-1) into the distal axons of trigeminal neurons favors the onset of nonproductive, silent infection. PLoS Pathog 8(5): e1002679.
  45. Veits, J., Weber, S., Stech, O., Breithaupt, A., Graber, M., Gohrbandt, S., Bogs, J., Hundt, J., Teifke, J. P., Mettenleiter, T. C. and Stech, J. (2012). Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype. Proc Natl Acad Sci U S A 109(7): 2579-2584.
  46. Klupp, B. G., Granzow, H. and Mettenleiter, T. C. (2011). Nuclear envelope breakdown can substitute for primary envelopment-mediated nuclear egress of herpesviruses. J Virol 85(16): 8285-8292.
  47. Muller, T., Hahn, E. C., Tottewitz, F., Kramer, M., Klupp, B. G., Mettenleiter, T. C. and Freuling, C. (2011). Pseudorabies virus in wild swine: a global perspective. Arch Virol 156(10): 1691-1705.
  48. Negatsch, A., Mettenleiter, T. C. and Fuchs, W. (2011). Herpes simplex virus type 1 strain KOS carries a defective US9 and a mutated US8A gene. J Gen Virol 92(Pt 1): 167-172.
  49. Fuchs, W., Fichtner, D., Bergmann, S. M. and Mettenleiter, T. C. (2011). Generation and characterization of koi herpesvirus recombinants lacking viral enzymes of nucleotide metabolism. Arch Virol 156(6): 1059-1063.
  50. Bogs, J., Kalthoff, D., Veits, J., Pavlova, S., Schwemmle, M., Manz, B., Mettenleiter, T. C. and Stech, J. (2011). Reversion of PB2-627E to -627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein. J Virol 85(20): 10691-10698.
  51. Gohrbandt, S., Veits, J., Hundt, J., Bogs, J., Breithaupt, A., Teifke, J. P., Weber, S., Mettenleiter, T. C. and Stech, J. (2011). Amino acids adjacent to the haemagglutinin cleavage site are relevant for virulence of avian influenza viruses of subtype H5. J Gen Virol 92(Pt 1): 51-59.
  52. Ramp, K., Skiba, M., Karger, A., Mettenleiter, T. C. and Romer-Oberdorfer, A. (2011). Influence of insertion site of the avian influenza virus haemagglutinin (HA) gene within the Newcastle disease virus genome on HA expression. J Gen Virol 92(Pt 2): 355-360.
  53. Kuhn, J., Leege, T., Granzow, H., Fuchs, W., Mettenleiter, T. C. and Klupp, B. G. (2010). Analysis of pseudorabies and herpes simplex virus recombinants simultaneously lacking the pUL17 and pUL25 components of the C-capsid specific component. Virus Res 153(1): 20-28.
  54. Maresch, C., Granzow, H., Negatsch, A., Klupp, B. G., Fuchs, W., Teifke, J. P. and Mettenleiter, T. C. (2010). Ultrastructural analysis of virion formation and anterograde intraaxonal transport of the alphaherpesvirus pseudorabies virus in primary neurons. J Virol 84(11): 5528-5539.
  55. Mohl, B. S., Bottcher, S., Granzow, H., Fuchs, W., Klupp, B. G. and Mettenleiter, T. C. (2010). Random transposon-mediated mutagenesis of the essential large tegument protein pUL36 of pseudorabies virus. J Virol 84(16): 8153-8162.
  56. Negatsch, A., Granzow, H., Maresch, C., Klupp, B. G., Fuchs, W., Teifke, J. P. and Mettenleiter, T. C. (2010). Ultrastructural analysis of virion formation and intraaxonal transport of herpes simplex virus type 1 in primary rat neurons. J Virol 84(24): 13031-13035.
  57. Muller, T., Klupp, B. G., Freuling, C., Hoffmann, B., Mojcicz, M., Capua, I., Palfi, V., Toma, B., Lutz, W., Ruiz-Fon, F., Gortarzar, C., Hlinak, A., Schaarschmidt, U., Zimmer, K., Conraths, F. J., Hahn, E. C. and Mettenleiter, T. C. (2010). Characterization of pseudorabies virus of wild boar origin from Europe. Epidemiol Infect 138(11): 1590-1600.
  58. Backovic, M., DuBois, R. M., Cockburn, J. J., Sharff, A. J., Vaney, M. C., Granzow, H., Klupp, B. G., Bricogne, G., Mettenleiter, T. C. and Rey, F. A. (2010). Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody. Proc Natl Acad Sci U S A 107(52): 22635-22640.
  59. Fereidouni, S. R., Werner, O., Starick, E., Beer, M., Harder, T. C., Aghakhan, M., Modirrousta, H., Amini, H., Moghaddam, M. K., Bozorghmehrifard, M. H., Akhavizadegan, M. A., Gaidet, N., Newman, S. H., Hammoumi, S., Cattoli, G., Globig, A., Hoffmann, B., Sehati, M. E., Masoodi, S., Dodman, T., Hagemeijer, W., Mousakhani, S. and Mettenleiter, T. C. (2010). Avian influenza virus monitoring in wintering waterbirds in Iran, 2003-2007. Virol J 7: 43.
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