联合评审(
Abhinit Nagar UMass Medical School, Worcestor, MA
3 protocols

Ali Asghar Kermani University of Michigan, Ann Arbor
8 protocols

Amberley D. Stephens Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge
3 protocols

ASWAD KHADILKAR UNIVERSITY OF CALIFORNIA SANTA CRUZ
11 protocols

编委
Alessandro Didonna
  • Assistant Adjunct Professor, University of California, San Francisco
研究方向
  • 神经科学
  • Neurodegeneration; Multiple Sclerosis; Autoimmunity; Protein Misfolding; Movement Disorders.
  • 已发表 protocol 0

教育背景

Ph.D. in Functional and Structural Genomics, International School for Advanced Studies (SISSA), 2010

实验室信息

Multiple Sclerosis Genetics Research Lab

发表论文

1. The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells. Mol Brain. 2021 Jan 21; 14(1):19.Ma Q, Didonna A. PMID: 33478569.

2. A splice acceptor variant in HLA-DRA affects the conformation and cellular localization of the class II DR alpha-chain. Immunology. 2021 Feb; 162(2):194-207.Didonna A, Damotte V, Shams H, Matsunaga A, Caillier SJ, Dandekar R, Misra MK, Mofrad MRK, Oksenberg JR, Hollenbach JA. PMID: 32986852.

3. Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020 Oct 12; 17(1):297.Ma Q, Matsunaga A, Ho B, Oksenberg JR, Didonna A. PMID: 33046105.

4. Tau at the interface between neurodegeneration and neuroinflammation. Genes Immun. 2020 11; 21(5):288-300.Didonna A. PMID: 33011744.

5. Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis. Proc Natl Acad Sci USA. 2020 09 22; 117(38):23742-23750.Didonna A, Canto Puig E, Ma Q, Matsunaga A, Ho B, Caillier SJ, Shams H, Lee N, Hauser SL, Tan Q, Zamvil SS, Oksenberg JR. PMID: 32878998.

6. TopoDB: a novel multifunctional management system for laboratory animal colonies. Database (Oxford). 2020 Jan 01; 2020.Renschen A, Matsunaga A, Oksenberg JR, Santaniello A, Didonna A. PMID: 33206961.

7. Mitoma H. Manto M. (eds) Neuroimmune Diseases. Contemporary Clinical Neuroscience. Genetic Factors in Neuroimmune Diseases. 2019; 357-386 .Didonna A,
Cantó E. View Publication.

8. The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders. Mol Neurodegener. 2019 05 16; 14(1):19.Didonna A, Opal P. PMID: 31097008.

9. Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation. J Autoimmun. 2019 07; 101:56-69.Didonna A, Cantó E, Shams H, Isobe N, Zhao C, Caillier SJ, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR. PMID: 31010726.

10. Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes. Hum Mol Genet. 2019 04 15; 28(8):1343-1356.Frederick NM, Shah PV, Didonna A, Langley MR, Kanthasamy AG, Opal P. PMID: 30590536.

11. Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1. J Clin Invest. 2018 06 01; 128(6):2252-2265.Edamakanti CR, Do J, Didonna A, Martina M, Opal P. PMID: 29533923.

12. Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. J Neuroinflammation. 2018 Mar 07; 15(1):72.Canto E, Isobe N, Didonna A, Hauser SL, Oksenberg JR. PMID: 29514694.

13. The Genetics of Multiple Sclerosis. Multiple Sclerosis: Perspectives in Treatment and Pathogenesis. 2017 Nov 14; 3-16.ALESSANDRO DIDONNA, JORGE R. OKSENBERG. .

14. Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci USA. 2017 08 15; 114(33):E6982-E6991.Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. PMID: 28760957.

15. Advances in Sequencing Technologies for Understanding Hereditary Ataxias: A Review. JAMA Neurol. 2016 Dec 01; 73(12):1485-1490.Didonna A, Opal P. PMID: 27749953.

16. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 08 22; 6:31603.Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE. PMID: 27546286.

17. Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies. Curr Med Chem. 2016; 23(14):1442-59.Didonna A. PMID: 27048376.

18. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8.Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg JR. PMID: 26433934.

19. Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c). PeerJ. 2015; 3:e811.Didonna A, Venturini AC, Hartman K, Vranac T, Curin Šerbec V, Legname G. PMID: 25802800.

20. Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta. 2015 Sep 20; 449:16-22.Didonna A, Oksenberg JR. PMID: 25661088.

21. Post-translational modifications in neurodegeneration. AIMS Biophysics. 2015 Jan 1; 3(1):27-49.Alessandro Didonna, Federico Benetti. .

22. The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurol. 2015 Jan; 2(1):79-101.Didonna A, Opal P. PMID: 25642438.

23. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15; 23(14):3733-45.Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. PMID: 24594842.

24. Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest. 2013 May; 123(5):1964-75.Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. PMID: 23585478.

25. Prion protein and its role in signal transduction. Cell Mol Biol Lett. 2013 Jun; 18(2):209-30.Didonna A. PMID: 23479001.

26. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. 2012 Jul 01; 6(3):309-16.Didonna A, Sussman J, Benetti F, Legname G. PMID: 22561161.

27. Infrared microspectroscopy: a multiple-screening platform for investigating single-cell biochemical perturbations upon prion infection. ACS Chem Neurosci. 2011 Mar 16; 2(3):160-74.Didonna A, Vaccari L, Bek A, Legname G. PMID: 22778865.

28. Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells. Mol Neurodegener. 2010 Aug 09; 5:29.Didonna A, Legname G. PMID: 20696038.
参审 protocol 6篇
Development of the Deoxycorticosterone Acetate (DOCA)-salt Hypertensive Rat Model
醋酸脱氧皮质酮盐型高血压大鼠模型的建立
作者:Nayara Pestana-Oliveira, David B. Nahey, Tim Johnson and John P. Collister日期:08/05/2020,浏览量:2182,Q&A: 0
According to the World Health Organization (WHO), nearly 1.13 billion people worldwide have hypertension, a major factor responsible for premature death globally. The inherent multifactorial nature of hypertension makes its study difficult since the ...
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Induction of Temporal Lobe Epilepsy in Mice with Pilocarpine
毛果芸香碱诱导小鼠颞叶癫痫
作者:Muhammad Nauman Arshad and Janice R Naegele日期:02/20/2020,浏览量:3067,Q&A: 0
In the pilocarpine model of temporal lobe epilepsy (TLE) in rodents, systemic injections of pilocarpine induce continuous, prolonged limbic seizures, a condition termed “Status Epilepticus” (SE). With appropriate doses, many inbred strains of mice ...
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主审 protocol 42篇
A Simple Method to Generate Super-sensitive AID (ssAID)-based Conditional Knockouts using CRISPR-based Gene Knockout in Various Vertebrate Cell Lines
小胶质细胞的分离及蛋白表达的流式细胞仪分析:避免小胶质细胞背景荧光的陷阱
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Inducing loss of function of a target protein using methods such as gene knockout is a powerful and useful strategy for analyzing protein function in cells. In recent years, the CRISPR/Cas-9-based gene knockout technology has been widely used across

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Sex-specific Separation of Plasmodium falciparum Gametocyte Populations
恶性疟原虫配子细胞群体的性别特异性分离
作者:Melanie C. Ridgway, Daniela Cihalova and Alexander G. Maier日期:06/05/2021,浏览量:1093,Q&A: 0

Plasmodium falciparum is a unicellular eukaryotic parasite that causes malaria in humans. The parasite is spread by Anopheles mosquitoes after ingestion of sexual stage parasites known as gametocytes. Malaria transmission depends on parasites

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