Education
Ph.D, Michigan State University, USA, 1988
Current position
Professor, Molecular & Cellular Biochemistry, Indiana University, USA
Publications (since 2013)
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Deng, X., Hackbart, M., Mettelman, R. C., O'Brien, A., Mielech, A. M., Yi, G., Kao, C. C. and Baker, S. C. (2017). Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages. Proc Natl Acad Sci U S A 114(21): E4251-E4260.
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Zhao, B., Yi, G., Du, F., Chuang, Y. C., Vaughan, R. C., Sankaran, B., Kao, C. C. and Li, P. (2017). Structure and function of the Zika virus full-length NS5 protein. Nat Commun 8: 14762.
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Deval, J., Jin, Z., Chuang, Y. C. and Kao, C. C. (2017). Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses. Virus Res 234: 21-33.
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Hoover, H. and Kao, C. C. (2016). Phosphorylation of the viral coat protein regulates infection. Virus Adaptation and Treatment 8: 13-20.
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Kao, C., Lin, X., Yi, G., Zhang, Y., Rowe-Magnus, D. A. and Bush, K. (2016). Cathelicidin Antimicrobial Peptides with Reduced Activation of Toll-Like Receptor Signaling Have Potent Bactericidal Activity against Colistin-Resistant Bacteria. MBio 7(5).
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Hoover, H., Vaughan, R., Wang, J., Middleton, S., Ni, P. and Kao, C. C. (2016). Phosphorylation regulates brome mosaic virus RNA encapsidation and infection. J. Virol. 90: 7748-7760.
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Yi, G., Ybe, J. A., Saha, S. S., Caviness, G., Raymond, E., Ganesan, R., Mbow, M. L. and Kao, C. C. (2016). Structural and Functional Attributes of the Interleukin-36 Receptor. J Biol Chem 291(32): 16597-16609.
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Kao, C. C., Yi, G. and Huang, H. C. (2016). The core of hepatitis C virus pathogenesis. Curr Opin Virol 17: 66-73.
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Rolfsson, O., Middleton, S., Manfield, I. W., White, S. J., Fan, B., Vaughan, R., Ranson, N. A., Dykeman, E., Twarock, R., Ford, J., Kao, C. C. and Stockley, P. G. (2016). Direct Evidence for Packaging Signal-Mediated Assembly of Bacteriophage MS2. J Mol Biol 428(2 Pt B): 431-448.
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Hu, Z., Hu, X., He, S., Yim, H. J., Xiao, J., Swaroop, M., Tanega, C., Zhang, Y. Q., Yi, G., Kao, C. C., Marugan, J., Ferrer, M., Zheng, W., Southall, N. and Liang, T. J. (2015). Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay. Antiviral Res 124: 20-29.
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Yi, G., Wen, Y., Shu, C., Han, Q., Konan, K. V., Li, P. and Kao, C. C. (2015). Genotype-specific inhibition of hepatitis C virus replication by cyclic GMP-AMP that activates STING-mediated immune responses. J. Virol. 90:254-265.
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Tsvetkova, I. B., Yi, G., Yi, Y., Kao, C. C. and Dragnea, B. G. (2015). Segmented GFP-like aptamer probes for functional imaging of viral genome trafficking. Virus Res 210: 291-297.
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Jin, Z., Tucker, K., Lin, X., Kao, C. C., Shaw, K., Tan, H., Symons, J., Behera, I., Rajwanshi, V. K., Dyatkina, N., Wang, G., Beigelman, L. and Deval, J. (2015). Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2'-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases. Antimicrob Agents Chemother 59(12): 7504-7516.
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Fan, B., Sutandy, F. X., Syu, G. D., Middleton, S., Yi, G., Lu, K. Y., Chen, C. S. and Kao, C. C. (2015). Heterogeneous Ribonucleoprotein K (hnRNP K) Binds miR-122, a Mature Liver-Specific MicroRNA Required for Hepatitis C Virus Replication. Mol Cell Proteomics 14(11): 2878-2886.
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Saha, S. S., Singh, D., Raymond, E. L., Ganesan, R., Caviness, G., Grimaldi, C., Woska, J. R., Jr., Mennerich, D., Brown, S. E., Mbow, M. L. and Kao, C. C. (2015). Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor. J Biol Chem 290(39): 23997-24006.
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Kitayama, M., Hoover, H., Middleton, S. and Kao, C. C. (2015). Brome mosaic virus Infection of Rice Results in Decreased Accumulation of RNA1. Mol Plant Microbe Interact 28(5): 626-632.
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Wen, Y., Lin, X., Fan, B., Ranjith-Kumar, C. T. and Kao, C. C. (2015). The juxtamembrane sequence of the Hepatitis C virus polymerase can affect RNA synthesis and inhibition by allosteric polymerase inhibitors. Virus Genes 51(1): 1-11.
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Vaughan, R. C. and Kao, C. C. (2015). Mapping protein-RNA interactions by RCAP, RNA-cross-linking and peptide fingerprinting. Methods Mol Biol 1297: 225-236.
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Fan, B., Ni, P. and Kao, C. C. (2015). Mapping RNA interactions to proteins in virions using CLIP-Seq. Methods Mol Biol 1297: 213-224.
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Rao, A. L. and Cheng Kao, C. (2015). The brome mosaic virus 3' untranslated sequence regulates RNA replication, recombination, and virion assembly. Virus Res 206: 46-52.
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Lin, X., Thorne, L., Jin, Z., Hammad, L. A., Li, S., Deval, J., Goodfellow, I. G. and Kao, C. C. (2015). Subgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases. Nucleic Acids Res 43(1): 446-460.
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Kao, C. and Peerson, O. (2014). Replication of plant and animal viruses. Curr. Opin. Virol. Special biennial issue, Elservier Press.
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Kao, C. and Peersen, O. (2014). Editorial overview: Replication of plant and animal viruses. Curr. Opin. Virol. 1-2.
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Yunus, M. A., Lin, X., Bailey, D., Karakasiliotis, I., Chaudhry, Y., Zhang, G., Thorne, L., Kao, C. and Goodfellow, I. (2014). Characterization of the murine norovirus subgenomic RNA promoter. J. Virol. 89: 1218-1229.
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Singh, D., Vaughan, R. and Kao, C. C. (2014). LL-37 peptide enhancement of signal transduction by Toll-like receptor 3 is regulated by pH: identification of a peptide antagonist of LL-37. J Biol Chem 289(40): 27614-27624.
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Wang, Z., Hryc, C. F., Bammes, B., Afonine, P. V., Jakana, J., Chen, D. H., Liu, X., Baker, M. L., Kao, C., Ludtke, S. J., Schmid, M. F., Adams, P. D. and Chiu, W. (2014). An atomic model of brome mosaic virus using direct electron detection and real-space optimization. Nat Commun 5: 4808.
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Perez-Vargas, J., Vaughan, R. C., Houser, C., Hastie, K. M., Kao, C. C. and Nemerow, G. R. (2014). Isolation and characterization of the DNA and protein binding activities of adenovirus core protein V. J Virol 88(16): 9287-9296.
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Yamane, D., McGivern, D. R., Wauthier, E., Ping, L., Yi, M., Madden, V. J., Wen, Y., Chugh, P. E., McGee, C. E., Widman, D. G., Kim, S., Shimakami, T., Welsch, C., Oikawa, T., Heise, M. T., Dittmer, D. P., Kao, C. C., Pitson, S. M., Merrill, Jr A. H., Reid, L. M. and Lemon, S. M. (2014). Regulation of hepatitis C virus replication by sphingosine kinase 2-mediated endogenous lipid peroxidation. Nat Med 20: 927-935.
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Wen, Y. and Cheng Kao, C. (2014). The hepatitis C virus core protein can modulate RNA-dependent RNA synthesis by the 2a polymerase. Virus Res 189: 165-176.
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Li, W., Zhang, Y. and Kao, C. C. (2014). The classic swine fever virus (CSFV) core protein can enhance de novo-initiated RNA synthesis by the CSFV polymerase NS5B. Virus Genes 49(1): 106-115.
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Vaughan, R., Tragesser, B., Ni, P., Ma, X., Dragnea, B. and Kao, C. C. (2014). The tripartite virions of the brome mosaic virus have distinct physical properties that affect the timing of the infection process. J Virol 88(11): 6483-6491.
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Ni, P., Vaughan, R. C., Tragesser, B., Hoover, H. and Kao, C. C. (2014). The plant host can affect the encapsidation of brome mosaic virus (BMV) RNA: BMV virions are surprisingly heterogeneous. J Mol Biol 426(5): 1061-1076.
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Fan, B., Lu, K. Y., Reymond Sutandy, F. X., Chen, Y. W., Konan, K., Zhu, H., Kao, C. C. and Chen, C. H. (2014). A human proteome microarray identified that the heterogeneous Ribonucleoprotein K (hnRNP K) recognizes the 5’ terminal sequence of the hepatitis C virus. Molec. Cell. Proteomics 13(1):84-92.
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Li, X., Shu, C., Yi, G., Chaton, C. T., Shelton, C. K., Diao, J., Zuo, X., Cheng Kao, C., Herr, A. B. and P. Li. (2013). Cyclic GMP-AMP synthase is activated by double-strand DNA-induced oligomerization. Immunity 39: 1019-1031.
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Park, I. W., Ndjomou, J., Wen, Y., Liu, Z., Ridgway, N. D., Kao, C. C. and He, J. J. (2013). Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation. PLoS One 8(9): e75648.
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Yi, G., Brendel, V., Shu, C., Li, P. and Kao, C. C. (2013). Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides. PLoS ONE 8(10): e77846.
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Ni, P. and Cheng Kao, C. (2013). Non-encapsidation activities of the capsid proteins of positive-strand RNA viruses. Virology 446(1-2): 123-132.
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Zhao, H., Y. Yang, Y., Janga, S. C., Kao, C. C. and Zhou, Y. (2013). Charting the unexplored RNA-binding protein atlas of the human genome by combining structure and binding predictions. Proteins 82: 640-647.
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Singh, D., Qi, R., Jordan, J. L., San Mateo, L. and Kao, C. C. (2013). The human antimicrobial peptide LL-37, but not the mouse ortholog, mCRAMP, can stimulate signaling by poly(I:C) through a FPRL1-dependent pathway. J Biol Chem 288(12): 8258-8268.
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Leen, E., Kwok, R., Birtley, J. B., Simpson, P. J., Subba-Reddy, Ch. V., Chaudry, Y., Sosnovtsev, S. V., Green, K. Y., Prater, S., Young, J., Chung, L. M., Marchant, J., Roberts, L. O., Kao, C. C., Matthews, S., Goodfellow, I. G. and Curry, S. (2013). Structures of the compact helical core domains of the mouse norovirus and the feline calicivirus VPg proteins. J. Virol. 87: 5318-5330