• Santoro B., Hu L., Liu H., Saponaro A., Pian P., Piskorowski R. A., Moroni A., Siegelbaum S. A., “Tetratricopeptide Repeat-Containing Rab8b Interacting Protein (TRIP8b) regulates hyperpolarization-activated cyclic nucleotide-regulated 1 (HCN1) channel trafficking and gating through two distinct C-terminal interaction sites”, The Journal of Neuroscience, 2011, 31(11): 4074-4086 [doi:10.1523/JNEUROSCI.5707-10.2011].
• Smeazzetto S., Saponaro A., Young H.S., Moncelli M.R., Thiel G., “Structure-Function Relation of Phospholamban: Modulation of Channel Activity as a Potential Regulator of SERCA Activity”, PLoS One., 2013, 8(1):e52744 [doi: 10.1371/journal.pone.0052744].
• Hu L., Santoro B., Saponaro A., Liu H., Moroni A., Siegelbaum S. A., “Binding of the auxiliary subunit TRIP8b to HCN channels shift the mode of action of cAMP”, The Journal of General Physiology, 2013, 142(6): 599-612 [doi: 10.1085/jgp.201311013].
• Saponaro A., Pauleta S.R., Cantini F., Hu L., Matzapetakis M., Hammann C., Donadoni C., Thiel G., Banci L., Santoro B., Moroni A. “Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function”, Proc Natl Acad Sci U S A., 2014, 111(40) :14577-82 [doi: 10.1073/pnas.1410389111].
• Weißgraeber S, Saponaro A., Thiel G., Hamacher K. “A reduced mechanical model for cAMP-modulated gating in HCN channels”. Sci Rep., 2017, 7:40168 [doi: 10.1038/srep40168].
• Saponaro A., Porro A., Chaves-Sanjuan A., Nardini M., Rauh O., Thiel G., Moroni A. “Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins”. Plant Cell. 2017, 29(10):2570-2580. [doi: 10.1105/tpc.17.00375].
• Saponaro A., Cantini F., Porro A., Bucchi A., DiFrancesco D., Maione V., Donadoni C., Introini B., Mesirca P., Mangoni M., Thiel G., Banci L., Santoro B., Moroni A. “A synthetic peptide that prevents cAMP regulation in mammalian Hyperpolarization-activated Cyclic Nucleotide-regulated (HCN) channels”. Elife. 2018, pii: e35753. doi: 10.7554/eLife.35753.
• Groß C., Saponaro A., Santoro B., Moroni A., Thiel G., Hamacher K. "Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel" J Biol Chem. 2018, pii: jbc.RA118.002139. doi: 10.1074/jbc.RA118.002139.
• Saponaro A. "Isothermal Titration Calorimetry: a Biophysical Method to Characterize the Interaction between Label-free Biomolecules in Solution". 2018, Bio-protocol, Vol 8, Iss 15. doi: 10.21769/BioProtoc.2957.
• Alberio L., Locarno A., Saponaro A., Romano E., Bercier V., Albadri S., Del Bene F., Simeaoni F., Moleri S., Beltrame M., Pelucchi S., MarcellO E., Di Luca M., Kukovetz K., Boender AJ.,Luo S., Moutal A., Ji Y., Khanna R., Colecraft H.M., Thiel G., Tonini R., Moroni A. "A light-gated K+ channel for sustained neuronal inhibition in freely moving animals". Nat Methods. 2018 Nov;15(11):969-976. doi: 10.1038/s41592-018-0186-9.
• Porro A, Saponaro A, Gasparri F, Bauer D, Gross C, Pisoni M, Abbandonato G, Hamacher K, Santoro B, Thiel G, Moroni A. “The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels”. Elife. 2019 Nov 26;8. pii: e49672. doi: 10.7554/eLife.49672.
• Brocca P, Saponaro A, Introini B, Rondelli V, Pannuzzo M, Raciti D, Corti M, Raudino A. “Protein Adsorption at the Air-Water Interface by a Charge Sensing Interferometric Technique”. Langmuir. 2019 Dec 10;35(49):16087-16100. doi: 10.1021/acs.langmuir.9b02201. Epub 2019 Nov 19.
• Kukovetz K, Hertel B, Schvarcz CR, Saponaro A, Manthey M, Burk U, Greiner T, Steward GF, Van Etten JL,Moroni A, Thiel G, Rauh O. “A Functional K + Channel from Tetraselmis Virus 1, a Member of the Mimiviridae”. Viruses, 2020 12(10):1107. doi: 10.3390/v12101107.
• Nardone V, Chaves-Sanjuan A, Lapi M, Airoldi C, Saponaro A, Pasqualato S, Dolfini D, Camilloni C, Bernardini A, Gnesutta N, Mantovani R, Nardini M. “Structural Basis of Inhibition of the Pioneer Transcription Factor NF-Y by Suramin”. Cells. 2020 9(11):2370. doi: 10.3390/cells9112370.
• Porro A, Binda A, Pisoni M, Donadoni C, Rivolta I, Saponaro A. “Rational design of a mutation to investigate the role of the brain protein TRIP8b in limiting the cAMP response of HCN channels in neurons”. J General Physiol. 2020, doi: 10.1085/jgp.202012596.
• Saponaro A, Maione V, Bonvin A. M. J. J., Cantini F. “Understanding Docking Complexes of Macromolecules Using HADDOCK: The Synergy between Experimental Data and Computations”. Bio-protocol, 2020, Vol 10, Iss 20. doi: 10.21769/BioProtoc.3793.
• Porro A, Thiel G, Moroni A, Saponaro A. “cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4”. Front. Physiol. 2020, doi: 10.3389/fphys.2020.00771.
• Saponaro A., Sharifzadeh A.S., Moroni A. “Detection of ligand binding to purified HCN channels using fluorescence-based size exclusion chromatography”. Methods Enzymol. 2021; 652:105-123. doi: 10.1016/bs.mie.2021.01.043.
• Saponaro A., Thiel G., Moroni A. “Structural and functional approaches to studying cAMP regulation of HCN channels”. Biochem Soc Trans. 2021 Dec 17;49(6):2573-2579. doi: 10.1042/BST20210290.
• Saponaro A.*, Lolicato M. “Editorial: The key role of lipids in the regulation of ion channels”. Front Physiol. 2022 Sep 7;13:1000082. doi: 10.3389/fphys.2022.1000082. eCollection 2022. * Also, corresponding author.
• Saponaro A.*, Vallese F., Porro A., Clarke O.B. “Validation of the binding stoichiometry between HCN channels and their neuronal regulator TRIP8b by single molecule measurements”. Front Physiol. 2022 Sep 26;13:998176. doi: 10.3389/fphys.2022.998176. eCollection 2022. * Also, corresponding author.
• Krumbach J., Bauer D., Sharifzadeh A.S., Saponaro A., Lautenschläger R., Lange K., Rauh O., DiFrancesco D., Moroni A., Thiel G., Hamacher K. “Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block”. J Gen Physiol. 2023, https://doi.org/10.1085/jgp.202313364.
• Kunzmann P, Krumbach JH, Saponaro A, Moroni A, Thiel G, Hamacher K. Anisotropic Network Analysis of Open/Closed HCN4 Channel Advocates Asymmetric Subunit Cooperativity in cAMP Modulation of Gating. J Chem Inf Model. 2024 Jun 24;64(12):4727-4738. doi: 10.1021/acs.jcim.4c00360.
• Porro A, Armano E, Brandalise F, Appiani R, Beltrame M, Saponaro A, Dallanoce C, Nakajo K, Ryu K, Leone R, Thiel G, Pallavicini M, Moroni A, Bolchi C. A Photoactivatable Version of Ivabradine Enables Light-Induced Block of HCN Current In Vivo. J Med Chem. 2024 Sep 26;67(18):16209-16221. doi: 10.1021/acs.jmedchem.4c01047.
• Porro A, Saponaro A*, Castelli R, Introini B, Hafez Alkotob A, Ranjbari G, Enke U, Kusch J, Benndorf K, Santoro B, DiFrancesco D, Thiel G, Moroni A. A high affinity switch for cAMP in the HCN pacemaker channels. Nat Commun. 2024 Jan 29;15(1):843. doi: 10.1038/s41467-024-45136-y. * Co-first author.
• Saponaro A, Krumbach JH, Chaves-Sanjuan A, Sharifzadeh AS, Porro A, Castelli R, Hamacher K, Bolognesi M, DiFrancesco D, Clarke OB, Thiel G, Moroni A. Structural determinants of ivabradine block of the open pore of HCN4. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2402259121. doi: 10.1073/pnas.2402259121.
• Saponaro A, DiFrancesco D. Structure mirroring function: What's the 'matter' with the funny current? J Physiol. 2025 Feb 27. doi: 10.1113/JP287209.