评审
Domenico Azarnia Tehran
  • Post-Doc, Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
研究方向
  • Biochemistry, Cell Biology, Neuroscience
Personal information

教育背景

University of Padova

实验室信息

Volker Haucke lab
http://www.leibniz-fmp.de/research/molecular-physiology-and-cell-biology/research-groups/haucke/department.html

发表论文

https://pubmed.ncbi.nlm.nih.gov/?term=domenico+azarnia+tehran&sort=date
Kuijpers M.*, Azarnia Tehran D.*, Haucke V. and Soykan T. The axonal endolysosomal and autophagic systems. Journal of Neurochemistry 2020 Dec 28 doi: 10.1111/jnc.15287
*co-first authorship

Azarnia Tehran D.*, Lopez-Hernandez T.* and Maritzen T. Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations. Cells 2019 Oct 29;8(11)
*co-first authorship

Azarnia Tehran D.* and Pirazzini M.*. Preparation of Cerebellum Granule Neurons from mouse or rat pups and evaluation of clostridial neurotoxin activity and their inhibitors by Western blot and immunohistochemistry. Bio-protocol 2018 8(13):e2981
*co-senior authorship

Azarnia Tehran D.* and Pirazzini M.*. Novel botulinum neurotoxins: exploring below the iceberg tip. Toxins. 2018 May 10(5), 190
*co-senior authorship

Pirazzini M, Azarnia Tehran D., Zanetti G., Rossetto O., Montecucco C. Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals. Toxicon. 2018 Jun 1;147:32-37. Epub 2017 Oct 28

Azarnia Tehran D.*, Kuijpers M.* and Haucke V. Presynaptic endocytic factors in autophagy and neurodegeneration. Curr Opin Neurobiol. 2018 Feb;48:153-159. Epub 2018 Jan 6
*co-first authorship

Azarnia Tehran D.*, Pirazzini M.*, Leka O., Mattarei A., Lista F., Binz T., Rossetto O., Montecucco C. Hsp90 facilitates the folding of clostridial neurotoxins enzymatic domain into host cell cytosol. Cell Microbiol. 2017 Feb 19(2)
*co-senior authorship

Anniballi F., Fillo S., Giordani F., Auricchio B., Azarnia Tehran D., Di Stefano E., Mandarino G., De Medici D., Lista F. Multiple-locus variable number of tandem repeat analysis as a tool for molecular epidemiology of botulism: The Italian experience. Infect Genet Evol. 2016 Dec;46:28-32. Epub 2016 Oct 19

Zornetta I.*, Azarnia Tehran D.*, Arrigoni G.*, Anniballi F., Bano L., Leka O., Zanotti G., Binz T., Montecucco C. The first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain. Sci. Rep. 2016 July 22; 6:30257
*co-first authorship

Schnell L., Mittler A.K., Mattarei A., Azarnia Tehran D., Montecucco C., Barth H. Semicarbazone EGA inhibits uptake of diphtheria toxin into human cells and protects cells from intoxication. Toxin (Basel). 2016 Jul 15; 8(221)

Schnell L., Mittler A.K., Sadi M., Popoff M.R., Schwan C., Aktories K., Mattarei A., Azarnia Tehran D., Montecucco C., Barth H. EGA protects mammalian cells from Clostridium difficile CDT, Clostridium perfrigens iota toxin and Clostridium botulinum C2 toxin. Toxins (Basel). 2016 Apr 1;8(4)

Pirazzini M., Azarnia Tehran D., Leka O., Zanetti G., Rossetto O., Montecucco C. On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments. Biochim Biophys Acta. 2016 Mar; 1853(3):467-74

Azarnia Tehran D.*, Zanetti G.*, Oneda L., Florigio L., Fillo S., Binz T.,
Clifford C.C., Rossetto O., Montecucco
C., Paradisi C., Mattarei A., Pirazzini M. A novel inhibitor prevents the peripheral neuroparalysis of botulinum neurotoxins. Sci Rep. 2015 Dec 16; 5:17513
*co-first authorship

Zanetti G.*, Azarnia Tehran D.*, Pirazzini M., Binz T., Shone C.C., Fillo S., Lista F., Rossetto O., Montecucco C. Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism. Biochem. Pharmacol. 2015 Dec 1; 98(3):522-30
*co-first authorship

Giordani F., Fillo S., Anselmo A., Palozzi A.M., Fortunato A., Gentile B., Azarnia Tehran D., Ciammaruconi A., Spagnolo F., Pittiglio V., Anniballi F., Auricchio B., De Medici D., Lista F. Genomic characterization of italian Clostridium botulinum group I strains. Infect Genet Evol. 2015 Dec; 36:62-71

Pirazzini M., Azarnia Tehran D., Zanetti G., Lista F., Binz T., Shone CC., Rossetto O., Montecucco C. The thioredoxin reductase-thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles. Toxicon. 2015 Dec; 107(Pt A):32-36

Pirazzini M.*, Azarnia Tehran D.*, Zanetti G., Megighian A., Scorzeto M., Fillo S., Shone C.C., Binz T., Rossetto O., Lista F., Montecucco C. Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins. Cell Rep. 2014 Sep 25;8(6):1870-8
*co-first authorship.