Mohan Babu
  • Post-Doc, Stanford University
  • Molecular Biology


PhD, Ita suomen yliopisto, 2019


Snyder Lab


Multi-omics and precision health

18. Multiomics for health. Babu M and Snyder MP. Molecular and Cellular Proteomics. 2023. DOI: (Invited Review)
17. Babu M, Devi T, Mäkinen P, Örd T, Aavik E, Kaikkonen M, Ylä-Herttuala S. ApoA-I nanotherapy rescues post-ischemic vascular maladaptation by modulating endothelial cell and macrophage phenotypes in type 2 diabetic mice. Arterioscler Thromb Vasc Biol. 2023: 2023;43: e46–e61.
16. Aavik E, Babu M, Ylä-Herttuala S. DNA methylation processes in atherosclerotic plaque. Atherosclerosis. 281 (2019) 168–179. (Invited Review)
15. Van Zuydam, N. R. et al. A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes. Diabetes.2018: 67(7):1414-1427 (Part of SUMMIT consortium).
14. Sandholm N, Van Zuydam N, Ahlqvist E et al. The genetic landscape of renal complications in type 1 diabetes. J Am Soc Nephrol. 2017; 28:557–574 (Part of SUMMIT consortium).
13. Devi T *, Babu M *, Mäkinen P, Kaikkonen M, Heinoniemi M, Laakso H, Ylä-Herttuala E, Rieppo L, Liimatainen T, Naumenko N, Tavi P, Ylä-Herttuala S. Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation. (* Shared first author). Am J Pathol. 2017:187: 2659-2673.
12. Babu M, Devi T, Mäkinen P, Kaikkonen M, Lesch H, Junttila S, Laiho A, Ghimire B, Gyenesei A, Yla-Herttuala S. Differential promoter methylation of macrophage genes is associated with impaired vascular growth in ischemic muscles of hyperlipidemic and type 2 diabetic mice: A Genome-Wide Promoter Methylation Study. Circulation Research. 2015; 117:289–299.
11. Bhardwaj S, Roy H, Babu M, Shibuya M, Yla-Herttuala S. Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation. Atherosclerosis. 2011; 219(1): 84-91. (Impact factor: 4.255, Citations: 32)
10. Roy H, Bhardwaj S, Babu M, Lähteenvuo J, Ylä-Herttuala S. VEGF-D∆N∆C Mediated Angiogenesis in Skeletal Muscles of Diabetic WHHL Rabbits. Eur J Clin Invest. 2010; 40(5): 422-32.
9. Viita H, Kinnunen K, Eriksson E, Lähteenvuo J, Babu M, Kalesnykas G, Heikura T, Laidinen S, Takalo T, Ylä-Herttuala S. Intravitreal adenoviral 15-lipoxygenase-1 gene transfer prevents vascular endothelial growth factor A-induced neovascularization in rabbit eyes. Hum Gene Ther. 2009; 20(12): 1679-86.
8. Viita H, Markkanen J, Eriksson E, Nurminen M, Kinnunen K, Babu M, Heikura T, Turpeinen S, Laidinen S, Takalo T, Ylä-Herttuala S. 15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and down regulation of VEGF receptor 2 expression. Circulation Research. 2008; 102(2): 177-84.
7. Räty S, Piironen A, Babu M, Pelli H , Sand J, Uotila S, Nordback I, Herzig KH. Screening for human cationic trypsinogen (PRSS1) and trypsinogen inhibitor gene (SPINK1) mutations in a Finnish hereditary pancreatitis family. Scand J Gastroenterol. 2007; 42(8):1000-5.
6. Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumaki J, Laakso M, Herzig KH, Yla-Herttuala S. VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits. FASEB J. 2006; 20(12):2159-61.
5. Roy H, Bhardwaj S, Babu M, Jauhiainen S, Herzig KH, Haisma HJ, Carmeliet P, Alitalo K, Ylä-Herttuala S . Adenovirus mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via up regulation of the expression of endogenous vascular endothelial growth factor-A. Human Gene Therapy. 2005; 16(12):1422-8
4. Babu M, Purhonen AK, Bansiewicz T, et al. Effect of total colectomy and PYY infusion on food intake and body weight in rats. Regul Pept. 2005; 131:29–33.
3. Kumar A, Babu M, Kimberling WJ, Venkatesh CP. Genetic analysis of a four-generation Indian family with Usher syndrome: a novel insertion mutation in MYO7A. Molecular Vision. 2004;10:910-6.
2. Kumar A, Babu M, Raghunath A, Venkatesh CP. Genetic analysis of a five generation Indian family with BPES: A novel missense mutation (p. Y215C). Molecular Vision. 2004; 10:445-9.
1. Kumar A, Blanton SH, Babu M, Markandaya M, Girimaji SC.Genetic analysis of primary microcephaly in Indian families: novel ASPM mutations. Clin Genet. 2004; 66(4):341-8.