Min Chen, Department of Toxicology and Cancer Biology, University Kentucky, 2013-2020

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Min Chen

Assistant Professor, Department of Toxicology and Cancer Biology, University of Kentucky, 2013-2020

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个人信息

教育背景

PhD, University of Texas Medical Branch, USA, 2011

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• Huang, X., Ye, Q., Chen, M., Li, A., Mi, W., Fang, Y., Zaytseva, Y. Y., O'Connor, K. L., Vander Kooi, C. W., Liu, S. and She, Q. B. (2019). N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals. Nat Commun 10(1): 3708.
• Liu, L., Qi, L., Knifley, T., Piecoro, D. W., Rychahou, P., Liu, J., Mitov, M. I., Martin, J., Wang, C., Wu, J., Weiss, H. L., Butterfield, D. A., Evers, B. M., O'Connor, K. L. and Chen, M. (2019). S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2. J Biol Chem 294(18): 7516-7527.
• Stewart, R. L., Carpenter, B. L., West, D. S., Knifley, T., Liu, L., Wang, C., Weiss, H. L., Gal, T. S., Durbin, E. B., Arnold, S. M., O'Connor, K. L. and Chen, M. (2016). S100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA-approved anti-helminthic agent niclosamide. Oncotarget 7(23): 34630-34642.
• Stewart, R. L., Carpenter, B. L., West, D. S., Knifley, T., Liu, L., Wang, C., Weiss, H. L., Gal, T. S., Durbin, E. B., Arnold, S. M., O'Connor, K. L. and Chen, M. (2016). S100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA-approved anti-helminthic agent niclosamide. Oncotarget 7(23): 34630-34642.
• Carpenter, B. L., Chen, M., Knifley, T., Davis, K. A., Harrison, S. M., Stewart, R. L. and O'Connor, K. L. (2015). Integrin alpha6beta4 Promotes Autocrine Epidermal Growth Factor Receptor (EGFR) Signaling to Stimulate Migration and Invasion toward Hepatocyte Growth Factor (HGF). J Biol Chem 290(45): 27228-27238.
• Chen, M., Knifley, T., Subramanian, T., Spielmann, H. P. and O'Connor, K. L. (2014). Use of synthetic isoprenoids to target protein prenylation and Rho GTPases in breast cancer invasion. PLoS One 9(2): e89892.
• Harrison, S. M., Knifley, T., Chen, M. and O'Connor, K. L. (2013). LPA, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cells. BMC Cancer 13: 501.
• O'Connor, K. and Chen, M. (2013). Dynamic functions of RhoA in tumor cell migration and invasion. Small GTPases 4(3): 141-147.
• Chen, M., Bresnick, A. R. and O'Connor, K. L. (2013). Coupling S100A4 to Rhotekin alters Rho signaling output in breast cancer cells. Oncogene 32(32): 3754-3764.
• O'Connor, K. L., Chen, M. and Towers, L. N. (2012). Integrin alpha6beta4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation. Am J Physiol Cell Physiol 302(3): C605-614.
• Chen, M., Sastry, S. K. and O'Connor, K. L. (2011). Src kinase pathway is involved in NFAT5-mediated S100A4 induction by hyperosmotic stress in colon cancer cells. Am J Physiol Cell Physiol 300(5): C1155-1163.
• Gulhati, P., Bowen, K. A., Liu, J., Stevens, P. D., Rychahou, P. G., Chen, M., Lee, E. Y., Weiss, H. L., O'Connor, K. L., Gao, T. and Evers, B. M. (2011). mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 71(9): 3246-3256.
• Chen, M., Sinha, M., Luxon, B. A., Bresnick, A. R. and O'Connor, K. L. (2009). Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin. J Biol Chem 284(3): 1484-1494.
• Chen, M., Towers, L. N. and O'Connor, K. L. (2007). LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells. Am J Physiol Cell Physiol 292(5): C1927-1933.
• Chen, M. and O'Connor, K. L. (2005). Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells. Oncogene 24(32): 5125-5130.
• Gosslau, A., Chen, M., Ho, C. T. and Chen, K. Y. (2005). A methoxy derivative of resveratrol analogue selectively induced activation of the mitochondrial apoptotic pathway in transformed fibroblasts. Br J Cancer 92(3): 513-521.
• Tian, Y., Ke, S., Chen, M. and Sheng, T. (2003). Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter. J Biol Chem 278(45): 44041-44048.
• Chen, M., Zhang, J. Z. and Bi, D. Z. (2000). Studies on the phylogenetic relationship between HL-93 strain and HL J-054 strain of SFGR. Chin J Zoonoses 16(3):12-16.
• Chen, M., Fan, M. Y. and Bi, D. Z. (1998). Detection, isolation and identification of spotted fever group rickettsiae from Ninghua county of Fujian Province. Chin J Microbiol Immunol 17(6):433- 437.
• Chen, M., Fan, M., Bi, D. and Zhang, J. (1998). [Cloning and sequence analysis of rOmpA gene fragment of spotted fever group Rickettsiae isolated in China]. Wei Sheng Wu Xue Bao 38(4): 276-282.
• Chen, M., Fan, M. Y., Bi, D. Z., Zhang, J. Z. and Chen, X. R. (1998). Sequence analysis of a fragment of rOmpA gene of several isolates of spotted fever group rickettsiae from China. Acta Virol 42(2): 91-93.
• Chen, M., Fan, M. Y., Bi, D. Z., Zhang, J. Z. and Huang, Y. P. (1998). Detection of Rickettsia sibirica in ticks and small mammals collected in three different regions of China. Acta Virol 42(1): 61-64.
• Chen, M., Fan, M. Y. and Xu, G. M. (1997). [Detection of north-Asia tick-borne spotted fever in ticks and rodents along the Heilongjiang river-side by restriction fragment length polymorphism of PCR products]. Zhonghua Liu Xing Bing Xue Za Zhi 18(1): 5-7.
• Chen, M., Fan, M. Y. and Bi, D. Z. (1997). [A molecular epidemiologic investigation of north Asia fever in scenic spots of Beijing suburb]. Zhonghua Liu Xing Bing Xue Za Zhi 18(4): 197-200.